UT Arlington Optical Medical Imaging Lab Projects
Kambiz Alavi, Ph.D.
Professor, Electrical Engineering
E-mail: alavi@uta.edu
Phone: 817-272-5633
Education: Ph.D., Massachusetts Institute of Technology, 1981
Areas of Expertise: Low-temperature grown GaAs, chirped superlattices for multiple quantum well waveguides and transverse electroabsorption modulators, superlattice and asymmetric quantum wells for infrared detectors.
Karel J. Zuzak, Ph.D.
Assistant Professor, Bioengineering
E-mail: kzuzak@uta.edu
Phone: 817-272-7318
Education: Ph.D., University of Minnesota, 1999
Areas of Expertise: Imaging instrumentation and spectral deconvolution methodology, cellular and molecular cardiology, implantable devices.
Drs. Alavi and Zuzak are developing a medical hyperspectral imaging system for surgical and clinical uses. The system will incorporate Texas Instruments’ DLP® technologies with a liquid crystal tunable filter. Potential uses include surgical cholesystectomy, clinical non-invasive disease detection and monitoring for example monitoring diabetic retinopathy and neuropathy leading to amputations. In addition, they are developing a microscopic hyperspectral imager for monitoring the development of diabetic retinopathy in a double knockout mouse model, in-vivo and non-invasively.
This project is being conducted in association with Drs. Edward Livingston and Rafael Unfret-Vincenty of UT Southwestern’s Department of Surgery and Ophthalmology and is supported in part by Texas Instruments.
George Alexandrakis, Ph.D.
Assistant Professor, Bioengineering
E-mail: galex@uta.edu
Phone: 817-272-3496
Education: Ph.D., McMaster University, Canada, 2000
Areas of Expertise: Biomedical engineering, physics, optical tomography, high resolution microscopy
Dr. Alexandrakis is currently investigating the dynamics of proteins involved in DNA repair by use of quantitative confocal cellular microscopy techniques. He will be looking at how DNA strand breaks (such as that caused by exposure to ionizing radiation during treatment of cancer) are being repaired by the cellular machinery.
He is also developing a multiparameter, two-photon microscopy suite to probe the transfer of physiologically important molecules between different cell compartments at very-high spatial resolution. The microscope has specialized hardware for photon counting and fluorescence correlation spectroscopy applications. These methods are used to quantify the reaction kinetics (diffusion coefficients, reactant concentrations, binding kinetics) of molecules. In addition he is actively pursuing projects on the optical tomographic imaging of tissues during clinical surgeries and in experimental animal models.
Dr. Alexandrakis is collaborating with Professor David Chen of UT Southwestern’s Radiation Oncology Department on this project.
Digant Davé, Ph.D.
Assistant Professor, Bioengineering
E-mail: ddave@uta.edu
Phone: 817-272-0946
Education: Ph.D., Texas A&M University, 1994
Areas of Expertise: Design and development of interfero-metric optical sensing systems for biomedical applications, design and development of optical coherence tomography (OCT) systems, applications of phase-sensitive OCT in biomedical applications.
Dr. Davé is using coherent optical tomography to locate targeted nanoparticles that have attached themselves to diseased organs.
Hanli Liu, Ph.D.
Professor, Bioengineering
E-mail: hanli@uta.edu
Phone: 817-272-2054
Education: Ph.D., Wake Forest University, 1994
Areas of Expertise: Medical instrumentation and imaging, minimally-invasive and non-invasive spectroscopy and imaging of tissue, optical diffuse imaging for cancer prognosis and brain activities.
Dr. Liu is using diffuse optical imaging to study functional brain activities and for tumor diagnosis and prognosis under a variety of treatments.
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