The University of Texas at Arlingon

  Frank W. Foss, Jr.       
Organic, Bioorganic, and Medicinal Chemistry


Assistant Professor

 

B.S., Chemistry, University of Richmond (1995-1999)

Ph.D., Organic/Medicinal Chemistry, 
University of Virginia (2000-2006)

Postdoctoral Fellow: Columbia University
Artificial Enzymes/Single-Molecule Electronic Devices
Breslow Research Laboratory (2006 – 2008)

 

Phone: 817-272-5245    FAX: 817-272-5220     E-mail: ffoss@uta.edu     Office: 202 CRB     Personal Page


Research interests:

Design and Properties of Novel Materials

Biomimetic Catalysis

Investigating Biomolecular Interactions

Selected Recent Publications:

Ronald Breslow, Frank W. Foss Jr., “Charge Transport in Nanoscale Aromatic and Antiaromatic Systems” Special Issue: Conductivity of single molecules and supramolecular architectures J. Phys.: Condens. Matter 2008, in press.

Huanyu Zhau, Frank W. Foss Jr, Ronald Breslow "Artificial Enzymes: Benzoin Condensations by Imidazolium and Thiazolium Catalysts" J. Am. Chem. Soc. 2008, in press.

Qin Sun, Ran Zhu, Frank W. Foss Jr., Timothy L. Macdonald “In Vitro Metabolism of a Model Cyclopropylamine to Reactive Intermediate: Insights into Trovafloxacin-Induced Hepatotoxicity” Chem. Res. Toxicol. 2008, 21, 711-719.

Guy Cinamon, Marcus A. Zachariah, Olivia M. Lam, Frank W. Foss Jr., Jason G. Cyster “Follicular Shuttling of Marginal Zone B Cells Facilitates Antigen Transport” Nature Immunology 2008, 9, 54-62.  (Highlighted by Georg Kraal “Antigens Take the Shuttle” Nature Immunology 2008, 9, 11-12. )

Qin Sun, Ran Zhu, Frank W. Foss Jr., Timothy L. Macdonald “Synthesis and Chemical Oxidation of a Model Cyclopropylamine: Identification of a Reactive Intermediate and Implication of Responsible Enzymes for Hepatotoxicity of Trovafloxacin” Bioorg. Med. Chem. Let. 2007, 17, 6682-6686.

Jordan R. Quinn, Frank W. Foss Jr., Latha Venkataraman, Ronald Breslow “Oxidation Potentials Correlate with Conductivities of Aromatic Molecular Wires” J. Am. Chem. Soc. 2007, 129, 12376-12377.

Jordan R. Quinn, Frank W. Foss Jr., Latha Venkataraman, Mark S. Hybertsen, Ronald Breslow “Single-Molecule Junction Conductance through Diaminoacenes” J. Am. Chem. Soc.  2007, 129, 6714-6715.

Frank W. Foss Jr., Ashley H. Snyder, Michael D. Davis, Michael Rouse, Mark D. Okusa, Kevin R. Lynch, Timothy L. Macdonald “Synthesis and Biological Evaluation of g-aminophosphonates as Potent, Subtype-Selective Sphingosine-1-Phosphate Receptor Agonists and Antagonists” Bioorg. Med. Chem. 2007, 15, 663-677;
(Recommended by Hugh Rosen: Faculty of 1000 Biology, 2 Feb 2007 http://www.f1000biology.com/article/id/1064759/evaluation; Top 50 Cited papers, BMC, 2004-2008.)

Janet V. Cross, Frank W. Foss Jr., Joshua M. Rady, Timothy L. Macdonald, Dennis J. Templeton “The Isothiocyanate Class of Dietary Chemopreventives Inhibits the Catalytic Activity of the MEKK1 Protein Kinase by Covalent Modification of the ATP Binding Domain” BMC Cancer 2007, 7:183.

Alaa S. Awad, Hong Ye, Liping Huang, Frank W. Foss Jr., Li Li, Timothy L. Macdonald, Kevin R. Lynch, Mark D. Okusa “Selective Sphingosine 1-Phosphate (S1P1) Receptor Activation Reduces Ischemia-Reperfusion Injury in Mouse Kidney” Am. J. Physiol.: Renal Physiol. 2006, 290, F1516 - F1524.

Frank W. Foss Jr., Jeremy J. Clemens, Michael D. Davis, Ashley H. Snyder, Kevin R. Lynch, Timothy L. Macdonald “Synthesis, Stability and Implications of Phosphothioate Agonists of Sphingosine-1-Phosphate Receptors” Bioorg. Med. Chem. Lett. 2005, 15, 4470-4474.

 

Department of Chemistry and Biochemistry
The University of Texas at Arlington
Arlington, Texas 76019-0065, USA
Phone: 817-272-3171 | Fax: 817-272-3808
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