Human Neural Cardiovascular Control Lab
About the Fadel Lab
Our laboratory’s research focus entails the investigation of neural cardiovascular control in human health and disease with a specific emphasis on the sympathetic branch of the autonomic nervous system. Two primary techniques we use are microneurography to obtain direct recordings of sympathetic neural firing and Doppler ultrasound to obtain beat-to-beat blood flow measures. Studies are performed on normal healthy subjects as well as patients with various pathophysiological conditions with a current emphasis on Type 2 Diabetes and Chronic Kidney Disease Patients. The Type 2 Diabetes studies are designed to better understand the role of insulin-mediated vasodilation in glucose uptake within skeletal muscle and how impairments may contribute to hyperglycemia with the ultimate goal of identifying new therapeutic targets in the treatment of Type 2 Diabetes. Our Chronic Kidney Disease studies will comprehensively test the hypothesis that elevated endogenous asymmetric dimethylarginine constitutes a major mechanism mediating sympathetic nervous system overactivity and hypertension in Chronic Kidney Disease. We aim to identify potential mechanisms that may drive sympathetic overactivity in Chronic Kidney Disease, particularly in pre-dialysis, so additional pharmacological therapies can be developed to effectively reduce sympathetic nerve activity in this high cardiovascular risk patient population. We also have multiple ongoing protects in healthy young and older individuals.