Human Neural Cardiovascular Control Lab
Our laboratory’s research focus entails the investigation of neural cardiovascular control in human health and disease with a specific emphasis on the sympathetic branch of the autonomic nervous system. Studies are performed on normal healthy subjects as well as patients with various pathophysiological conditions with a current emphasis on Type 2 Diabetes and Chronic Kidney Disease Patients.
The Type 2 Diabetes studies are designed to better understand the role of insulin-mediated vasodilation in glucose uptake within skeletal muscle and how impairments may contribute to hyperglycemia with the ultimate goal of identifying new therapeutic targets in the treatment of Type 2 Diabetes.
Our Chronic Kidney Disease studies will comprehensively test the hypothesis that elevated endogenous asymmetric dimethylarginine constitutes a major mechanism mediating sympathetic nervous system overactivity and hypertension in Chronic Kidney Disease. We aim to identify potential mechanisms that may drive sympathetic overactivity in Chronic Kidney Disease, particularly in pre-dialysis, so additional pharmacological therapies can be developed to effectively reduce sympathetic nerve activity in this high cardiovascular risk patient population.
We also have multiple ongoing projects in healthy young and older individuals.
Recent Lab Publications
Paul J. Fadel, PhD
Director, Human Neural Cardiovascular Control Lab
Professor, Department of Kinesololgy
Associate Dean for Research, CONHI
Current Lab members are listed on the Lab Members page.
Measurements and Experimental Procedures
|Duplex Doppler Ultrasound Measures of Peripheral Blood Flow|
|Microneurography Measures of Sympathetic Nerve Activity|
|Sympathetic Vascular Transduction|
|Pulse Wave Analysis & Velocity Measurement|
|Peripheral Blood Mononuclear Cell Isolation and Analyses|
Standard cardiopulmonary measures (e.g. ECG, BP, respiration); Transcranial Doppler measures of cerebral blood flow; Near-infrared spectroscopy measures of muscle oxygenation; Blood sampling for various biomarkers; Metabolic assessments
|Arterial Baroreflex Function|
Other Experimental Procedures:
Lower body negative pressure; Single leg kicking; Rhythmic and static handgrip; Post-exercise ischemia; VO2max testing; Oral glucose tolerance testing; Hyperinsulinemic/euglycemic clamps