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College of Nursing and Health Innovation | The University of Texas at ArlingtonCollege of Nursing and Health Innovation | The University of Texas at Arlington

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Touching Lives. Transforming Health Care.

Sympathetic Vascular Transduction

Aside from quantifying sympathetic nerve firing, we also are interested in assessing how sympathetic nerve activity is transduced into a blood pressure response. For this, a signal-averaging approach to sympathetic transduction has been utilized extensively in our lab. Specifically, each "burst" of sympathetic outflow (depicted below) is tracked for 10-15 heart beats and associated with the corresponding blood pressure changes over that time period. In addition, blood flow (see other techniques) is also used, to track how sympathetic outflow decreases blood flow over 15 heart beats (i.e. vasoconstriction). The activity is then further characterized to provide insight into how different burst patterns and sizes affect blood pressure and blood flow.

burst sympathetic outflow
signal averaging
Example of signal averaging procedure from one subject. Dotted Lines represent changes in mean arterial pressure (MAP) related to individual bursts of sympathetic outflow across 10 cardiac cycles, and the solid line represents the average MAP response for all bursts.