Integrative Immunology Laboratory
The Integrative Immunology Laboratory at University of Texas at Arlington is focused on how the immune system interacts with other tissues to regulate cardiovascular and metabolic function. Our research seeks to determine how the aging immune system interacts with the blood vessels and adipose tissue to contribute to the increased risk of cardiovascular disease and type 2 diabetes that occurs with advanced age. We are also interested in how lifestyle interventions like exercise might prevent or reverse these age-related pathologies. To approach these research questions, we employ a translational approach, utilizing cell culture and animal models, as well as human tissues.
Dr. Daniel Trott
Integrative Immunology Laboratory Director & Assistant Professor, Department of Kinesiology
Joining the Lab
The Integrative Immunology Laboratory at The University of Texas at Arlington is seeking graduate students interested in our lab. Students will learn integrative physiology, vascular biology and immunology techniques. Prior basic science lab experience is preferred but not required. Interested students should contact Dr. Daniel Trott (firstname.lastname@example.org) for more information.
Isolated Artery Preparation: This technique allows us to assess vasodilator and vasoconstrictor function in resistance arteries that are important in regulation of systemic vascular resistance and local blood flow.
Large Artery Stiffness: Assessing pulse wave velocity with Doppler ultrasound allows us to determine the relative compliance/stiffness of the large elastic arteries.
Flow Cytometry: Flow Cytometry allows us to assess tissue infiltration and phenotype of immune cells and the systemic vs. local kinetics of these cells.