SW-4-3-6: Micro Manipulation and Its Challenging Bio Application

Prof. Tatsuo Arai, Osaka University

Abstract

We have been developing micro manipulation system capable of handling, assembling, and fabricating micro objects with the size ranging from 1um to 100um. In our nearly 20 year R&D history we have been designing and building dexterous two fingered micro hands, sophisticated sensing facilities including micro vision systems, micro force sensors, and usable interfaces. Our major interest is the application in the bio fields, e.g. manipulating and characterizing single cell, providing nice tools for skillful complicated tasks required in bio experiments and developments. The various utilities and the attractive applications will be demonstrated in the presentation.

With the recent advancements in the tissue bio science we have proposed and launched new national project called “Hyper Bio Assembler for 3D Cellular Innovation” where we are aiming to develop and study construction of in-vitro 3D tissue by applying micro robotics technology. The project has just started in August this year and will continue for 5 years. We have organized a consortium including 9 research groups from robotics, biology, and medical. The budget is totally Y1.2B supported by MEXT. The key issues are 1) measuring and characterizing cells in high speed to select and separate useful ones for active functionalized tissue, 2) assembling and fabricating 3D cellular system by applying micro manipulation and fluidic technologies, and 3) analyzing and evaluating functional expressions of cellular system. Through measuring cell/cellular system and controlling the interaction between cellular system and its environment we would try to achieve truly active 3D tissue in vitro as a world first achievement. The project summary will be introduced briefly.

Speaker Biography

Tatsuo ARAI was born in 1952 in Tokyo. He received B.S. M.S. and PhD degrees from the University of Tokyo in 1975, 1977, and 1986 respectively. He joined the Mechanical Engineering Laboratory, AIST, MITI (now METI) in 1977, and was engaged in research and development of new arm design and control, mobile robot, teleoperation, and micro robotics. He stayed at MIT as a visiting scientist in 1986-1987. He moved to Osaka University in 1997 and since then he has been a full professor at the Department of Systems Innovation, Graduate School of Engineering Science. His current research topics are mechanism design including parallel mechanisms, legged working robot, micro robotics for bio applications, humanoid robot, haptic interface, and network robotics. He has published more than 300 journal and conference papers on robotics and automation, 6 books, and has 37 patents including foreign 8. He is a member of IEEE, International Association of Automation and Robotics in Construction (IAARC), Robotic Society of Japan (RSJ), Society of Instrumentation and Control Engineers, Japan Society of Mechanical Engineers (JSME), and other societies. He is currently an Editor-in-Chief of Journal of Robotics and Mechatronics. He served as Vice President of IAARC, Chair of Robotics and Mechatronics Division of JSME, a Director of RSJ, Chair of the Technical Advisory Committee of the Destruction of Abandoned Chemical Weapon of the Cabinet Office.