September 20, 2013 |
Nedderman Hall Rm 100 | Seminar Flyer
Rutledge Ellis-Behnke, Ph.D.
Dept. of Ophthalmology, Medical Faculty Mannheim; University of Heidelberg, Germany; Dept. of Brain & Cognitive Sciences, MIT
How understanding cell morphology and nanoscale structural change can lead to a framework, objective measures and treatments that can help restore the body to a pre-injury state.
Refreshments will be served at 10:40 am.
The intersection of nanotechnology and healthcare forces us to completely rethink how to approach restoration or enhancement of the body. Tissue engineering is no longer taking a cell, placing it in a particular scaffold, putting it back in the body and hoping that everything will reconnect and function properly. It is the ability to influence an environment either by adding, subtracting or manipulating that environment to allow it to be more conducive for its purpose. This also drives the understanding of how nanomaterials interact during manufacture, during and post application, and how the environment can change the structure.
The use of nanomaterials will be shown in 1. CNS regeneration: specifically the restoration of vision after trauma using self-assembling nanomaterials. 2. How physical measures can be used as a diagnostic for glaucoma at the nanoscale, years before current diagnosis, using nanoindentation or Femtosecond laser. 3. Immediate hemostasis. Hemostasis is a major problem after trauma and during surgery; as much as 50% of surgical time can be spent packing wounds to reduce or control bleeding, with few effective methods to stop it. We showed that hemostasis can be achieved in less than 15 seconds, using selfassembling nanomaterials without relying on heat, pressure, platelet activation, adhesion, or desiccation to stop bleeding.
Finally, how some of these technologies and materials are fundamentally causing us to rethink how we practice medicine, from diagnosis to surgical intervention (Crystal Clear Surgery).