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UT Arlington-led research reveals new details about the immunity of sea stars dying along the West Coast

Tuesday, July 28, 2015

Media Contact: Bridget Lewis, Office:817-272-3317, Cell:214-577-9094, blewis@uta.edu

A study led by a University of Texas at Arlington graduate student examining sea stars dying along the West Coast provides new clues about the starfish’s immune response and its ability to protect a diverse coastal ecosystem.

Fuess and Dr. Mydlarz discuss their research into the mysterious disease attacking sea stars.

Lauren Fuess, a Ph.D. candidate in quantitative biology, and her team looked at the wasting disease responsible for the largest die-off of sea stars ever recorded. Scientists believe that a virus related to rabies causes wasting disease. When infected, the stars’ arms contort, and they develop white lesions. The normally rigid stars begin to melt and become squishy in the final stages of the disease.

Wasting disease affects nearly 20 different species and it has caused up to almost 90 percent mortality in some areas off the West Coast over the last two years.

“The sea stars protect the rocky shores, keeping them from becoming dominated by mussels,” Fuess said. “When you remove the sea stars, you see dramatic declines of other species, so basically you go from a diverse ecosystem to a mussel-coated beach.”

The team researched the project looking at transcriptomes, or the molecules expressed from the genes, of sea stars infected with wasting disease as part of an Ecology of Infection Marine Disease course last summer at Friday Harbor Laboratories at the University of Washington.  

Fuess, who recently received a National Science Foundation Graduate Research fellowship, works in the laboratory of Laura Mydlarz, a UT Arlington associate professor of biology.

“We’re looking at an increasing rate of diseases that may be linked to climate change as well as pollution in the ocean,” Mydlarz said. “What we’re working on at our field sites and here at UT Arlington is looking to see if some of this temperature stress due to climate change or pollution are causing the animals, such as the sea stars and the corals, to be more susceptible to diseases."

“Lauren’s research here is a great example of student excellence in this area.”

The team found that the sea stars have an immune response that is characterized by various types of immunities and that they have multiple aspects of the toll-signaling pathway, which is an important recognition.

“It’s how a cell recognizes a pathogen and then elicits a change in its genes so that the sea star can start defending itself against the pathogen,” Fuess said. “We found a lot of interesting genes – including the first melanin gene ever recorded in a sea star. Invertebrates can use melanin to wall off pathogens or any bacteria-like viruses that are attacking them.”

Fuess is a doctoral candidate in quantitative biology at UT Arlington.

The team also found several changes in the extra cellular matrix and collagen gene.

“Genes that degrade collagen, which is a component of the sea stars’ structure, were being increased in the stars we studied,” Fuess said. “So, you have more degradation of that essential collagen and breakdown of the matrix that is used for their movement and rigidity. We also saw changes in nervous genes that might be contributing to that twisting of the arms.”

The title of the new study is “Up in Arms: Immune and Nervous System Response to Sea Star Wasting Disease.” The paper was published online this month by the journal PLOS ONE and is available here:  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133053.

Co-authors are: Morgan E. Eisenlord, Collin J. Closek, Allison M. Tracy, Ruth Mauntz, Sarah Gignoux-Wolfsohn, Monica M. Moritsch, Reyn Yoshioka, Colleen A. Burge, C. Drew Harvell, Carolyn S. Friedman, Ian Hewson, Paul K. Hershberger, and Steven B. Roberts.

About the College of Science

The UT Arlington College of Science is addressing the nation’s pressing need for a larger and better-prepared STEM work force. We have 42 undergraduate and graduate degree offerings in six departments, and we’re equipping future leaders in science through award-winning classroom teaching and lab training. Our internationally acclaimed faculty is leading the way in innovative research and is finding solutions to some of the world’s most challenging problems. Visit www.uta.edu/cos to learn more about how the College of Science is changing the world through education and research.

About The University of Texas at Arlington

The University of Texas at Arlington is a comprehensive research institution of more than 51,000 students in campus-based and online degree programs and is the second-largest institution in The University of Texas System. The Chronicle of Higher Education ranked UT Arlington as one of the 20 fastest-growing public research universities in the nation in 2014. U.S. News & World Report ranks UT Arlington fifth in the nation for undergraduate diversity. The University is a Hispanic-Serving Institution and is ranked as a “Best for Vets” college by Military Times magazine. Visit www.uta.edu to learn more, and find UT Arlington rankings and recognition at http://www.uta.edu/uta/about/rankings.php.

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