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Book Flyer
Doped Nanomaterials and Nanodevices Edited by Wei Chen, Department of Physics, University of Texas at Arlington
(book flyer)

 

 

 

Nano-Bio Physics group collaborates with Agiltron Inc. on Radiation Detection For homeland security
Dr. Wei Chen as a collaborator, along with Dr. King Wang (principal investigator and Vice President), Dr. Guiquan Pan and Dr. Jinsong Huang (key investigators) at Agiltron Inc. were awarded a Phase-II SBIR grant of $750,000 from DOD Defense Threat Reduction Agency (DTRA) for research on Bulk Composite Materials For Detection of Gamma Radiation. A subcontract of $200,264 is awarded to UTA Nano-Bio Physics group for the design and synthesis of scintillation nanoparticles for radiation detection.

Physics Professor sheds new lights for Breast Cancer Treatment
http://www.uta.edu/ucomm/mediarelations/press/2009/10/Wei-Chen-gets-DOD-grant.php
News Release — 13 October 2009
FOR IMMEDIATE RELEASE
Media contact: Sue Stevens, Senior Media Relations Officer, 817-272-3317, sstevens@uta.edu
ARLINGTON - A University of Texas at Arlington physics professor believes photodynamic therapy, which has been used successfully in treating skin cancers, may be an effective treatment for breast cancer.
With the help of a $472,000 grant from the Department of Defense Congressionally Directed Medical Research Programs, Wei Chen is researching a new photodynamic therapy activated by long-lasting afterglow nanoparticles. Chen, an assistant physics professor, proposes a new therapy system that uses light generated by afterglow nanoparticles.
The nanoparticles are joined with photosensitizers that can produce a toxin called singlet oxygen. The combined nanopartical and photosensitizers are coated with targeting molecules that can recognize cancer cells. When the combination is targeted to the tumor cells, light from the nanoparticles activates the photosensitizers to produce the toxin, which destroys tumor cells.
No external light is required for treatment. That means the therapy can be used to treat deep tumors, such as breast cancer, because the light source is attached to the photosensitizers and they are delivered together to the tumor cells.
Chen said the first step is to develop optimal control of particle characteristics, such as afterglow efficiency and longevity. The nanoparticles will be rigorously characterized and tested for photodynamic activation to include efficacy and toxicity in cultures of cells produced in petri dishes as well as in live animal studies. The ultimate goal is to make this new technology available to help patients to fight cancers. Chen has formed a team with national and international researchers. Collaborators for the project are Dr. Xiankai Sun from the University of Texas Southwestern Medical Center in Dallas, Dr. Alan G. Joly from Pacific Northwest National Laboratory; Dr. Petras Juzenas from Norwegian Radium Hospital, Oslo, Norway and Dr. Syed F. Ali from the Food and Drug Administration's National Center for Toxicological Research.


In the summer of 2009, Dr. Wei Chen visited several universities in China for collaborations and student recruiting. The research at Nano-Bio Physics is attractive to audiences there. Many perspective students and researchers showed their interests in our Nano-Bio Physics group for potential collaborations. http://mse.wit.edu.cn/news.asp?id=910
 
China visit and student recruiting Potential Collaboration


Taking a shine to treatment:
O.K. Carter, a journalist of UTA Research Magazine, interviewed Dr. Wei Chen and reported his research activities in the issue of 2009. http://www.uta.edu/ucomm/researchmagazine/2009/features/Right-on-target.php
(alternate link here)

Dr. Wei Chen’s paper entitled “Nanoparticle fluorescence based technology for biological applications” as published in JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY in March, 2008 has been identified by Thomson Reuters’ as a Fast Breaking Paper in the field of Materials Science, which means it is one of the most cited papers in its discipline published during the past two years. http://sciencewatch.com/dr/fbp/2009/09junfbp/09junfbpChen/ (alternate link here)

A joint publication from Nano-Bio Physics group was selected a covert story at Advanced Drug Delivery Reviews. The article was one of the 25 hottest articles identified by Science Direct in October-December 2008 and was ranked as 4th  in Pharmacology, Toxicology and Pharmaceutical Science.
Petras Juzenas, Wei Chen, Ya-Ping Sun, Manuel Alvaro Neto Coelho, Roman Generalov, Natalia Generalova  and Ingeborg Lie Christensen, Quantum dots and nanoparticles for photodynamic and radiotherapy of cancer, Advanced Drug Delivery Reviews, 2008, 60 (15): 1600-1614


Awards for 2008
Members at Nano-Bio Physics group received several awards for the academic year of 2008.

  • Research Excellent Award: Dr. Wei Chen
  • Outstanding Physics Major Award: Xing (Bob) Zhang
  • Scharff Award Scholarship: Boon Kuan Woo
  • Bonnie Cecil Thompson Award: Mingzhen Yao

Dr. Wei Chen edited a special issue of Journal of Biomedical Nanotechnology on Cancer nanotechnology, Volume 4, Number 4 (December 2008) pp.367-547,
http://www.aspbs.com/jbn

December 3, Research Day 2008, College of Science, UTA
Poster presentation Nanoscale Phosphors For Radiation Detection from Nano-Bio Physics group won the Research day prize of 2008.

Dr. Wei Chen was assigned as the American Editor for Journal of Nanoscience and Nanotechnology (JNN) and Associate Editor for Journal of Biomedical Nanotechnology (JBN) published by American Scientific Publisher. Dr. Chen has edited two special issues for JNN and he is editing one special issue of JBN on Cancer Nanotechnology.

     
Journal of Biomedical Nanotechnology - December 2008
Journal of Nanoscience and Nanotechnology - March 2008
Journal of Nanoscience and Nanotechnology - September 2005


Nano-Bio Physics Group Collaborating with Agiltron Inc. on a SBIR Phase-I project “Bulk Composite Materials for Detection of Gamma Radiation” from DOD, HDTRA1-08-P-0034, $100,000. The project aims to design and synthesis nanocomposite materials for radiation detection.


Physics professor researching Nanotechnology to improve photodynamic therapy for breast cancer treatment

http://www.uta.edu/ucomm/mediarelations/press/2008/07/breast-cancer-treatment.php
News Release — 18 July 2008
FOR IMMEDIATE RELEASE
Media contact: Sue Stevens, (817) 272-3317, sstevens@uta.edu
ARLINGTON - A University of Texas at Arlington professor believes photodynamic therapy, which has been used successfully in treating skin cancers, can be an effective treatment for breast cancer. But the potentially life-saving treatment has been thwarted by the difficulty of light penetration into deep tissue. Wei Chen, an assistant professor of physics, thinks he knows how to overcome that obstacle.
With the help of a $109,155 grant from the Department of Defense Congressionally Directed Medical Research Programs, Chen will research a new photodynamic therapy (PDT) mediated by long-lasting afterglow nanoparticles. He proposes a new PDT system with light generated by afterglow nanoparticles with attached photosensitizers. When the nanoparticle-photosensitizer conjugates are targeted to tumor, the light from afterglow nanoparticles will activate the photosensitizers for photodynamic therapy. Therefore, no external light is required for treatment. That means the therapy can be used to treat deep tumors such as breast cancer because the light source is attached to the photosensitizers and is delivered to the tumor cells together. 
Chen said the first step is to generate routine synthesis with optimal control of particle characteristics such as afterglow efficiency and longevity. The nanoparticles will be rigorously characterized and then tested for photodynamic activation, to include efficacy and toxicity in vitro cultures of cells.  
To learn more about the research, contact Chen at (817) 272-1064.


Accolades

UT Arlington Today — 3 April 2008
Drs. Wei Chen and Ron Schachar were mentioned in a University of Ulster press release concerning research that deals with the treatment of cataracts. They are conducting the research with Professor Barbara Pierschionek of the University of Ulster. Dr. Chen is a UT Arlington assistant professor of physics and a nanotechnologist. Dr. Schachar is an ophthalmologist and physicist. Read the entire press release here.


February 11, 2008, Nanowerk News
Nanoparticle self-lighting photodynamic therapy for deep cancer treatment
http://www.nanowerk.com/spotlight/spotid=4466.php


January 4, 2008 Physics News, UTA

http://www.uta.edu/physics/main/phys_news/news/2008/index.html
Physics Assistant Professor Dr. Wei Chen, approached a lens physiologist [Professor Barbara K Piersionek of the University of Ulster] and an ophthalmologist [Ronald A. Schachar, M.D., Ph.D. of the University of Texas at Arlington] to study the biochemical causes of cataractogensis. They use quantum dots made at Dr. Chen’s lab to investigate the diffusion processes into lens. Their work is interesting as it might uncover the causes of cataractogensis and figure out the channels for drug delivery to cure cataracts. The preliminary results of their research were published in a prestigious Journal NANOTECHNOLOGY http://www.iop.org/EJ/abstract/0957-4484/19/2/025102/ And there are two reports related to their work at Nanowerk and Nanotechweb at links below: http://www.nanowerk.com/spotlight/spotid=3894.php and http://nanotechweb.org/cws/article/lab/32322.


January 4, 2008, Nanowerk News
Nanotechnology treatment for most common cause of blindness becomes feasible
http://www.nanowerk.com/spotlight/spotid=3894.php


January 2, 2008, Nanotechweb News
Possible role for nanotechnology in the treatment of cataracts
http://nanotechweb.org/cws/article/lab/32322


Nanoflowers (snow Flakes) generated through nanoparticle self-assembly by Dr. Wei Chen, UTA Department of Physics were used for cover of seasonal greeting cards by College of science, UTA, 2007


Quantum dots made at Dr. Chen’s group are on the cover of Maverick Science, College of science, UTA, Issue of Fall 2007


August 14, 2007, UTA Today

http://www.uta.edu/public-affairs/pressreleases/page.php?id=2129
Professors Awarded National Science Foundation Grant
 ARLINGTON—University of Texas at Arlington Assistant Professor of Physics Wei Chen is the principal investigator and Associate Professor Andrew Brandt is the co-principal investigator for a $300,000 three year-grant from the National Science Foundation/Department of Homeland Security Academic Research Initiative. Alan Joly of Pacific Northwestern National Lab is a collaborator.
The investigators will use nano-particles to detect uranium to aid in homeland security. Detecting uranium is a critical concern due its potential for use in nuclear terrorism. Although there have recently been significant improvements in the development of scintillator materials, no current scintillator has the ideal combination of properties.
The researchers plan to develop a novel kind of nanostructure phosphor for radiation detection. They will pursue two avenues for scintillation luminescence enhancement: coating scintillation Nan particles to silver and gold nanoparticles and using periodic surface patterning as in LED enhancement.
The effective combination of the two approaches could yield a multiplicative enhancement factor. This unique approach has noteworthy intellectual merit as improved scintillation devices would have applications in radiation detection and a myriad of other areas.

 


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