October 28, 2009

"In situ analysis of DNA damage response and repair using laser microirradiation"

Professor Kyoko Yokomori
University of California-Irvine


The proper recognition and repair of DNA damage is critical for the cell to protect its genomic integrity. However, it is difficult to study the in vivo kinetics and factor requirements of the damage recognition processes in the cell. In this talk, several different laser systems used to analyze in vivo DNA damage responses will be summarized and compared to other experimental approaches, such as conventional whole cell gamma irradiation and endonuclease-induced DNA breaks, in terms of their advantages and limitations. Finally, our findings using laser systems to examine the in vivo DNA damage responses in human cells will be presented.


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