Phase Sensitive Interferometry for Label Free Quantification of Biomolecular Interactions

Dr. Digant Dave
UT Arlington

Phase sensitive interferometry (PSI) is an attractive alternative to surface plasmon resonance (SPR) technique for label free detection of biomolecular interactions.  Using PSI, ultra small (sub 100 pm) changes in optical path length (OPL) can be measured. Binding of biomolecule to functionalized sensor surface results in OPL modulation which can be measured and quantified with PSI.  In the talk, I will present the development of spectral domain phase sensitive interferometric technique in our laboratory for quantitative detection of biomolecular interactions in a convention flow cell platform and on optical fiber tips.