Linda I. Perrotti
Assistant Professor of Psychology

Room 511, Life Sciences Bldg.
Phone: (817) 272-1202
Email: perrotti@uta.edu

Description of Research

Dr. Perrotti's research focuses on short- and long-term cellular, molecular, and behavioral consequences of exposure to a variety of stressors on the development of addictive behavioral phenotypes and relapse to addictive behavioral patterns. Her laboratory will examine the role of transcription factors in mediating the affects of stress and/or corticotropin releasing hormone in affective disorders and other stress-related conditions including a dual diagnosis with drug addiction. Dr. Perrotti's lab will use an integrative approach to assess molecular changes in signaling pathways, anatomical changes in brain reward circuitry, and examine behavioral modifications induced by stress and drug treatments.

Representative Publications

Perrotti, L.I., Bolanos, C.A., Choi, K.H., Russo, S.J., Edwards, S., Ulery, P.G., Wallace, D.L., Self, D.W., Nestler, E.J., & Barrot, M. FosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur. J. Neurosci. 2005. May; 21 (10): 2817-24.

Perrotti, L.I., Hadeishi, Y., Ulery, P.G., Barrot, M., Monteggia, L., Duman, R.S., & Nestler, E.J. Induction of DFosB in reward-related brain structures after chronic stress. J. Neurosci. 2004 Nov 24;24(47):10594-602.

Perrotti, L.I., Lu, D., Niyomachai, T., Cornejo, S., Russo, S.J., Jenab, S., & Quinones-Jenab, V. Temporal effects of estrogen and progesterone on behavioral and endocrinological responses to acute cocaine administration. Cell Mol Biol. 2003 Dec; 49(8):1269-74.

Perrotti, L.I., Russo, S.J., Fletcher, H., Chin, J., Webb, T., Jenab, S., & Quinones-Jenab, V. Ovarian hormones modulate cocaine-induced locomotor and stereotypic activity. Ann NY Acad Sci. 2001 Jun;937:202-16.

Perrotti, L.I., Beck, K.D., Luine, V.N., & Quinones, V. Progesterone and cocaine administration affect serotonin in the medial prefrontal cortex of ovariectomized rats. Neurosci. Lett. 2000 Sep 22;291(3):155-8.