Dr. Linda I. Perrotti

Dr. Linda I. Perrotti

  • Associate Professor of Psychology
  • Email: perrotti@uta.edu
  • Phone: (817) 272-1202
  • Address: Room 511, Life Sciences Bldg.
  • Website: Click to View
  • Description of Research


    My research interests center on determining how two vulnerability factors, anxiety and female sex influence the induction, development, progression and neurobiology of drug addiction. A second area of interest is the further examination of the “tail of the ventral tegmental area” or “rostromedial tegmental nucleus” (tVTA/RMTg) as a major nucleus modulating dopamine-driven drug reward. Using rodents as model organisms, I investigate initiation, acquisition, expression, extinction and reacquisition of conditioned drug reward. I am particularly interested in the biochemical and neuroendocrine factors which predispose certain individuals to respond differentially to drugs of abuse. The goal our research is to better understand the biological basis of this disease and to identify major biological targets for potential therapeutic intervention to promote abstinence and prevention.

    Representative Publications


    Ansari K I, Kasir S, Hussain S, Morris-Bobzean SA, Perrotti LI, Mandal SS. (2013) MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo. Molecular Endocrinology, 27(1):92-105.

    Dennis TS, Beck KD, Morris Bobzean SA, Liegey Dougall A, Perrotti LI. (2012) Assessing learned associations between conditioned cocaine reward and environmental stimuli in the Wistar-Kyoto rat. Pharmacology Biochemistry & Behavior, 103 (1), 76-82.

    Uhelskli ML, Morris-Bobzean SA, Dennis TS, Perrotti LI, Fuchs PN. (2011) Evaluating underlying neuronal activity associated with escape/avoidance behavior in response to noxious stimulation in adult rats. Brain Research, 1433, 56-61.

    Morris Bobzean SA, Dennis TS, Addison BD, Perrotti LI, (2010) Influence of sex on reinstatement of cocaine-conditioned place preference. Brain Research Bulletin83(6),331-6.

    Russo SJ, Renthal W, Kumar A, Green TA, Perrotti LI, Mazei-Robison M, Grahan A,  Birnbaum S, Robison B, Lesselyong A, Clark MS, Neve RL, Bhakar AL, Barker PA, Bolanos CA, Nestler EJ. (2009) NFκB signaling regulates cocaine-induced behavioral and cellular plasticity. Journal of Neuroscience, 29(11), 3529-37.

    Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A, Graham DL, Green TA, Kirk A, Iñiguez SD, Perrotti LI, Barrot M, DiLeone RJ, Nestler EJ, Bolaños-Guzmán CA. (2008) The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. Journal of Neuroscience, 28(41), 10272-77.

    Perrotti LI, Weaver RR, Robison B, Renthal W, Maze I, Yazdani S, Elmore RG, Knapp DJ, Selley DE, Martin BR, Sim-Selley L, Bachtell RK, Self DW, Nestler EJ. (2008) Distinct patterns of DeltaFosB induction in brain by drugs of abuse. Synapse, 62(5), 358-369.

    Salgado H, Bellay T, Nichols JA, Bose M, Martinolich L, Perrotti L, Atzori M. (2007). M2 muscarinic receptors decrease the release of GABA in the auditory cortex by modulating Ca2+ channels through activation of PI3K/PKC. Journal of Neurophysiology98, 952-65.

    Winstanley CA, LaPlant Q, Theobald DEH, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW, Nestler EJ. (2007) ΔFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunctionJournal of Neuroscience, 27(39),10497-507.

    Gemelli T, Berton O, Nelson E, Perrotti LI, Jaenisch R, Monteggia LM. (2006) Postnatal loss of MeCP2 in the forebrain is sufficient to mediate behavioral aspects of Rett Syndrome in mice. Biological Psychiatry59(5):468-76.

    Barrot M, Wallace-Black D, Graham D, Bolanos C, Perrotti LI, Neve RL, Chambliss H, Yin JC, Nestler EJ. (2005). Regulation of sexual anxiety by CREB. Proc National Acad Sci (PNAS), 102 (23); 8357-62.

    Perrotti LI, Bolaños CA, Choi KH, Russo SJ, Edwards S, Ulery PG, Wallace DL, Self DW, Nestler EJ, Barrot M. (2005) DFosB accumulates in a GABAergic cell population in the posterior tail of the VTA after psychostimulant treatment. European Journal of Neuroscience, 21; 2817-24.

    Perrotti LI, Hadeishi Y, Ulery PG, Barrot M, Monteggia L, Duman RS, Nestler EJ.(2004). Induction of DFosB in reward-related brain structures after chronic stressJournal of Neuroscience, 24(47):10594-10602.

    McClung CA, Ulery PG, Perrotti LI, Zachariou V, Berton O, Nestler EJ. (2004) DFosB: A Molecular Switch for long-term adaptation. Molecular Brain Research 132(2); 146-154.

    Perrotti LI, Lu D, Nioymachai T, Cornejo S, Russo SJ, Jenab S, Quiñones -Jenab V. (2003). Temporal effects of estrogen and progesterone on behavioral and endocrinological responses to acute cocaine administration. Cell Molecular Biology, 49(8):1269-74.

    Bolaños CA, Perrotti LI, Edwards S, Eisch AJ, Barrot M, Olson VG, Russell DS, Neve RL, Nestler EJ. (2003). Phospolipase Cg in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. Journal of Neuroscience, 23(20): 7569-76.

    Peakman MC, Colby C, Perrotti LI, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen MR, Stock JL, Duman RS, McNeish JD, Barrot M, Self DW, Nestler EJ, Schaeffer E(2003) Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research, 970(1-2):73-86.

    Barrot M, Olivier JDA, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC,  Zachariou V, Nestler EJ. (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci (PNAS), 99(17):11435-40.

    Chin J, Sternin O, Wu HBK, Burrell S, Lu D, Jenab S, Perrotti LI, Quiñones -Jenab V. (2002) Endogenous gonadal hormones modulate behavioral and neurochemical responses to acute and chronic cocaine administration. Brain Research, 945(1):123-30.

    Jenab S, Niyomchai T, Chin J, Festa ED, Russo SJ, Perrotti LI, Quiñones -Jenab V. (2002) Effects of cocaine on c-fos and preprodynorphin mRNA levels in intact and ovariectomized Fischer rats. Brain Research Bulletin, 58(3):295-99.

    Chin J, Sternin O, Wu HB, Fletcher H, Perrotti LI, Jenab S, Quiñones -Jenab V. (2001) Sex differences in cocaine-induced behavioral sensitization. Cell and Mol Biology, (6):1089-95.

    Perrotti LI, Russo SJ, Fletcher H, Chin J, Webb T, Jenab S, Quiñones -Jenab V. (2001) Ovarian hormones modulate cocaine-induced locomotor and stereotypic activity. Annals of the New York Academy of Sciences, 937(1):202-16.

    Quiñones-Jenab V, Perrotti LI, Fabian SJ, Chin J, Russo SJ, Jenab S. (2001). Endocrinological basis of sex differences in cocaine-induced behavioral responses. Annals of the New York Academy of Sciences,937(1):140-71.

    Perrotti LI, Russo SJ, Lagos F, Quiñones -Jenab V. (2001) Vendor differences in cocaine-induced Behavioral activity and hormonal interactions in ovariectomized Fischer rats. Brain Research Bulletin, 54(1):1-5.

    Quiñones-Jenab V, Perrotti LI, McMonagle J, Ho A, and Kreek MJ. (2000) Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized Fischer rats. Pharmacology, Biochemistry and Behavior, 67(3):417-22.

    Perrotti LI, Beck KD, Luine VN, and Quiñones-Jenab, V. (2000) Progesterone and cocaine administration affect serotonin in the medial prefrontal cortex of ovariectomized rats. Neuroscience Letters, 291(3):155-8. 

    Quiñones-Jenab V, Perrotti LI, Ho A, Jenab S, Schlussman SD, Franck J and Kreek MJ (2000) Cocaine affects progesterone plasma levels in female rats. Pharmacology, Biochemistry and Behavior, 66(2):449-53.