Development of confocal and two-photon microscopy techniques for sub-cellular imaging. Fluorescence correlation spectroscopy, scanning correlation spectroscopy methods. Development of diffuse reflectance, fluorescence and bioluminescence tomography methodologies.
After completing graduate work, he was a postdoctoral fellow at Massachusetts General Hospital / Harvard Medical School where he worked on quantitative intravital two-photon microscopy techniques for the analysis of barriers to drug delivery in tumor-bearing mice. He then pursued further postdoctoral work at UCLA where he contributed to the development of a combined optical/PET mouse imaging system and was also exposed to clinical multi-modality imaging.
In collaboration with faculty at UT Southwestern Dr. Alexandrakis currently investigates the dynamics of proteins involved in DNA repair by use of quantitative confocal cellular microscopy techniques. He is also developing a multi-parameter two-photon microscopy suite to probe the trafficking of physiologically important molecules between different cell compartments at very high spatial resolution. In addition, he is actively pursuing projects on optical tomographic imaging of tissues during surgery in the clinic and of experimental animal models.
F. Tian, G. Alexandrakis, and H. Liu. "Optimization of probe geometry for diffuse optical brain imaging based on measurement density and distribution," Appl. Opt., vol. 48, pp. 2496-2504, 2009.
Journal Article
Refereed/Juried
Published
2009
Z. J. Lin, G. Alexandrakis, N. L. Patel, J. Shen, L. Tang, and H. Liu. "Time-gated optical imaging to detect positive prostate cancer margins," in SPIE Photonics West (San Jose, CA, 2009), pp. 716119-1-9.
Conference Proceeding
Refereed/Juried
Published
2009
G. Alexandrakis, N. L. Patel, P. Rajamahendravarapu, Z. J. Lin, and H. Liu. "Relative capacities of time-gated versus CW imaging to localize tissue embedded vessels with increasing depth," in SPIE Photonics West (San Jose, CA, 2009), pp. 71740B-1-9.
Conference Proceeding
Refereed/Juried
Published
2009
G. Alexandrakis, K. Behbehani, F. Tian, B. Khan, N. Asanani, and H. Liu. "Translation of near infrared brain imaging to assess children with cerebral palsy," in SPIE Photonics West (San Jose, CA, 2009), pp. 718005-1-9.
Conference Proceeding
Refereed/Juried
Published
2008
K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston. "Intraoperative Bile Duct Visualization Using Near-Infrared Hyperspectral Video Imaging," Am. J. Surgery, vol. 195, pp. 491-497, 2008.
Introduction to the science and technology behind tissue optical imaging systems and their design requirements for different clinical applications. Diffuse optical tomography, fluorescence tomography, bioluminescence tomography, multi-modality imaging.
Download Syllabus (39.5KB. This syllabus was uploaded Saturday 15th, August 2009 12:52:37 PM and is subject to change.)
Contact Information Phone: 817 272 3496 Email: galex@uta.edu
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