College of Earth Science, Jilin University, Changchun, China
1985
Research and Expertise
Nanoparticle based therapeutics for cancer treatment
We are interested in developing luminescence nanoparticle based therapeutics for cancer treatment, such as photodynamic therapy, radiotherapy and photo-therapy. We have proposed a new concept of modality for cancer treatment that combines radiotherapy and photodynamic therapy . Under this concept, luminescent nanoparticles with attached photosensitizers are used as a new type of agent for photodynamic therapy. Upon exposure to ionizing radiation such as X-ray, light will emit from the nanoparticles to activate the photosensitizers; as a consequence, singlet oxygen (1O2) is produced to augment the killing of cancer cells by ionizing radiation. With this novel therapeutic approach, no external light is necessary to activate the photosensitizing agent within tumors. Thus, we call this new modality nanoparticle self-lighting photodynamic therapy. This new concept of cancer modality will be more efficient for deep tumor but requires less radiation dose than conventional radiotherapy.
Nanoparticle based Dosimetry
The development of scintillation nanoparticles and the demonstration of their applicability for dosimetry and radiation dose imaging. Once the concept is successfully demonstrated, it will be a great improvement for dose control in radiotherapy and will greatly benefit cancer patients by offering protection to adjacent healthy tissues.
Water soluble nanoparticles for In vivo oxygen (hypoxia) measurement in tumor
Hypoxia is a common effect in tumor and is one of the major determinants of cancer resistance to radiation therapy, chemotherapy and photodynamic therapy. It is of great importance to interrogate tumor oxygen concentration and distribution. In this project, we will demonstrate the potential for using near infrared nanoparticles and oxygen intensity quenching and time-resolved decay lifetime techniques for hypoxia imaging in tumor.
X-ray computed radiography improvement by quantum size confinement
Computed radiography (CR) is a promising digital imaging technique that offers many advantages over conventional X-ray film techniques and other digital methods. However, current X-ray storage systems suffer from significant shortcomings, such as relatively low spatial resolution and slower image processing. In this project, we will use size effect as well s quantum size confinement to improve the X-ray storage imaging quality.
Multifunctional nanoparticles for medical imaging
In this project, we will design and fabricate multifunctional nanoparticles that can be used for targeting, fluorescence imaging as well as magnetic resonance imaging.
Nanoparticles for Functional Imaging and Detection
Accepted/In-press Wei Chen, Nanoparticle Based Photodynamic Therapy for Cancer Treatment, Cancer Nanotechnology, Edited by Hari Singh Nalwa and Thomas Webster, published by American Scientific Publishers, Los Angeles (in press). Category: Books and Chapters
Book
Current
Accepted/In-press N. Kristianpoller, Wei Chen, D. Weiss, D. Kuzmin, and R. Chen, Irradiation effects in Ba-halide crystals, Phys. Stat. Sol. (accepted) Category: Journal Article
Peer reviewed
Current
Accepted/In-press Rene Alvarez, Blake Anderson, Les Jones, Craig Weeks, Wei Chen and Ralph A. Tripp, Bioconjugated Nanoparticles for the Detection of Respiratory Syncytial Virus, Int. J. Nanomedicine (accepted) Category: Journal Article
Peer reviewed
Current
Accepted/In-press Guohua Li, Fuhai Su, Wenjie Wang, Kun Ding, Wei Chen, Yuanfeng Liu and Alan G. Joly, Pressure Behaviour of the UV and Green Emission Bands in ZnO Micro-rods, Phys. Stat. Sol. (accepted) Category: Journal Article
Peer reviewed
Current
Accepted/In-press Yongbin Zhang, Wei Chen, Jun Zhang, Jing L. Pope, Guangping Chen and Carey Pope, In Vitro and in vivo Toxicity of CdTe Nanoparticles, J. Nanosci. Nanotechnol. (in press) Category: Journal Article
Peer reviewed
Presentations and Projects
Nanoparticle Based Photodynamic Therapy for Cancer Treatment - 2006
Particle 2006 on medical/biochemical diagnostic, pharmaceutical, and drug delivery applications of particle technology Orlando, Florida 13-16 May 2006
Nanoparticles for in vivo imaging - 2005
79th ACS Colloid and Surface Science Symposium, Clarkson University, Potsdam, New York, June 12-15,2005, invited by Prof. John Texter
Nanoparticle Fluorescence Based Technology - 2005
The ONI, Oklahoma Nanotechnology Initiative, Oklahoma Nanotechnology Conference, Cox Convention Center, OKC, Nov. 17-18, 2005
Luminescent Nanoparticles and Their Applications in Display and Biology - 2004
OK Nano-Net, OSU, 1/15/04, invited by Prof. Warren Ford
Some ideas for using nanoparticles in Biomedical sciences - 2004
Radiation Biology Branch National Cancer Institute, 8/17/04, invited by Dr. James Mitchell
Highly luminescent nanoparticles for solid state lighting, Solid Sate Lighting - 2004
DOE, 8/18/04, invited by Dr. Edward Petrow
Biological applications of luminescent nanoparticles, Nanoscale Science and Engineering Center - 2004
University of Georgia, Athens, 10/29/04, invited by Dr. Yiping Zhao
Deep green nanoparticles, Workshop on Solid State Lighting - 2004
DOE, January, 2004, invited by Dr. James Brodrick
Luminescent Nanoparticles and Applications, - 2003
SPIE meeting, Photonics Society of Chinese Americans, invited by Dr. Owen Wu, August 10, 2003
Introduction of Optical Properties of Nanoparticles - 2003
Department of Electrical Engineering, OSU, 11/25/03, invited by Dr. Weili Zhang
Luminescent Nanoparticles and Their Potential Applications in Biology - 2002
National Institutes of Health, Bethesda, July 12, 2002, invited by Dr. Amir H. Gandjbakhche
Nanoparticles formed within porous hosts: A new type of phosphor and storage device - 2002
SPIE Annual Conference, Seattle, 2002 invited by Drs. Jin Z. Zhang and Zhonglin Wang
Temperature Dependence and Upconversion Luminescence Mechanism in Doped Nanoparticles - 2002
June 16-21, 2002, 6th Internal Meeting in Nanostructured Materials, Orlando, Florida
Nanoparticle Fluorescence Based Technology for Biological Applications, UT Southwestern - 12/6/2006
Department of Radiology, Radiological Sciences, Biomedical Engineering & Cancer Imaging Program, Fall 2006 Seminar Series, invited by Prof. Ralph Mason
Luminescence of Semiconductor Nanoparticles
Naval Research Laboratories, Washington D. C. July 11, 2002
Affiliations
Center for Veterinary Health Sciences, Oklahoma State University
Prof. Carey Pope
Department of Materials Chemistry, University of Lund, Sweden
Prof. Jan-Olov Bovin
Guangxi Medical University, China
Prof. Guangwu Huang
Harvard Medical School
Prof. Michael R Hamblin
ICX-Nomadics Inc
Dr. Sarah Westcott, Dr. Shaopeng Wang and Dr. Yuangfanf Liu
Institute of Semiconductors, Chinese Academy of Sciences
Prof. Guohua Li
Lawrence Berkeley National Laboratory
Dr. Samuel Mao
NCI/NIH, Bethesda
Dr. Jacek Capala, Dr. Paul Smith and Dr. Nicole Morgan
NCI/NIH, Fredrick
Dr. Robert Blumenthal and Dr. Yossef Raviv
Pacific Northwester National Laboratory
Dr. Alan Joly,Senior staff scientists
Society Memberships
Member of American Chemical Society
Member of American Association for the Advancement of Science
Member of the Optical Society of American
Member of the American Physical Society
University of Georgia, Athens
Prof. Ralph Tripp
Appointments
Duration
Rank
Department / School
College / Office
University / Company
2006-Current
Assistant Professor
Department of Physics
College of Science
The University of Texas at Arlington
2005-Current
Associate Editor
American Scientific Publishers, California
2000-2006
Senior Scientist and Department Head
Nomadics Inc, Oklahoma
1999-2000
Senior visiting scientist
Chemical Physical Center, University of Western Ontario, London, Canada
1998-1999
Postdoctoral researcher
Department of Materials Chemistry
Lund University, Sweden
1997-1998
Senior Scientist
Institute of Semiconductors, CAS, Beijing
1996-1998
Deputy director
Laboratory of Semiconductor Materials science (LSMS)
Institute of Semiconductors Chinese Academy of Sciences (CAS), Beijing
1994-1997
Research Scientist
Institute of Semiconductors, CAS, Beijing
1992-1994
Postdoctoral Fellow
Department of Materials Physics
University Of Sciences & Technology, Beijing, China
Synergistic Activities
Professional Activities
Associate Editor, Journal of Nanoscience and Nanotechnology (JNN) Member of the Editorial Board of Journal of Nanoscience and Nanotechnology (JNN) Guest Editor, JNN a special issue on doped Nanomaterails, 2005, 5 (9) Chair of Chinese Science Society in Stillwater, OK (2003-2004) Proposal Reviewer: National Nature Science Foundation of China (1994 – 1998), NSF (USA), USDA (USA) and Israel – USA Bi-National Science Foundation (BNSF). Panelist: 1 NSF on Materials and manufacturing (2003) Executive Chair and Organizer Bi-conference between China and Sweden on Semiconductor Materials, Beijing, May 21-23, 1998 Executing Chair and Organizer, National Conference on II-VI compounds, June 5-11, 1996, Zhangjiajia, Hunan, China Committee Chair, Oversea Chinese International Conference on Doped Nanoparticles, Haikou, Hainan, 23-25/11/2006
Referee: Science in China, Chinese Journal of Luminescence, Journal of Material Science and Technology, Journal of Nanoscience and Nanoechnology, Journal of Materials Science: Materials in Electronics, Journal of Physical Chemistry A & B, Journal of Alloys and Compounds, Journal of Physics Condensed Matters, Journal of Electrochemical Society, Journal of Molecular Structures, Chemical Physics – Chemistry, Journal of the American Chemical Society, Journal of Vacuum Science And Technology, Nanotechnology, Powder Technology, Applied Physics Letters, Journal of Luminescence, IEEE Transactions on Nanotechnology, Materials Letters, European Chemistry
Support
Duration
Title
Sponsor
Amount
Status
2006-2008
Hydrogen Generation Using Integrated Photovoltaic and Photoelectrochemical Cells
Department of Energy, DE-FG02-05ER46232-A00 (Co-PI with Jin Z. Zhang)
$450,000
Current
2006-2008
Initiative of Nano-Bio-Physics Program
UTA-Startup grant (PI)
$350,000
Current
2006-2007
Development of nanotechnology for cancer imaging and treatment
UTA-LERR Fund (PI)
$65,500
Current
2005-2007
Nanoparticle Self-Lighting Photodynamic Therapy for Ovarian Cancer Treatment
Army Medical, W81XWH-05-C-0101-Phase-II (PI)
$730,000
Current
2005-2006
Water-soluble nanoparticles for oxygen imaging in tumor
National Institute of Health, 1R43 CA112756-01 (PI)
$100,000
Current
2005-2006
Nanoparticle Self-Lighting Photodynamic Therapy for Ovarian Cancer Treatment
Army Medical, W81XWH-05-C-0101-Option (PI)
$50,000
Current
2005-2006
Nanotechnology-based System for the Detection and Photodynamic Neutralization of BW Agents
Army Construction Engineering, W9132T-06-C-0004 (PI)
$120,000
Current
2004-2006
Scintillation Luminescence System for In-Vivo Dosimetry
National Institute of Health, 1 R43 CA110091-01 (PI)
$400,000
Current
2004-2006
Nanoparticle Self-Lighting Photodynamic Therapy for Ovarian Cancer Treatment
Army Medical, W81XWH-05-C-0101-Phase-I (PI)
$70,000
Previous
2004-2005
New efficient Nanophase Materials for Blue and Deep Green LEDs
Department of Energy, DOE-FG02-04ER84023 (PI)
$100,000
Previous
2003-2005
Ecologically Benign Corrosion Protection by Stratified Coating
AFOSR -F49620-03-C-0034I (PI)
$500,000
Previous
2002-2004
Nanoparticle Based Photostimulated Luminescence Optical Storage
NSF-DMI-0132030-Phase-II (PI)
$500,000
Previous
2002-2003
Improvement of X-ray Storage by Nanofabrication
NIH-1R43CA94403-1 (PI)
$100,000
Previous
2001-2003
Nanoparticle thin film panel for video displays
Oklahoma Center for Advanced Science and Technology (OCAST) (Co-PI with Nicholas A. Kotov)
$300,000
Previous
2000-2002
Thin Film Light Emitting Diodes From Layer-by-layer Assembled Semiconductor Nanoparticles
AFOSR-F49620-00-C-0058 (Co-PI with Colin Cumming)
$750,000
Previous
1997-2000
New Type Phosphors Composed by Rare Earth Doped Semiconductor Nanocrystals and Organic Materials
National Nature Science Foundation of China (PI)
RMB $450,000
Previous
1995-1997
Preparation and Potential Applications of Semiconductor Nanoclusters
President Foundation of Chinese Academy of Sciences (PI)
RMB $350,000
Previous
1993-1995
Mossbauer Spectra of Eu-doped X-ray Storage Phosphors
National Nature Science Foundation of China (PI)
RMB $45,000
Previous
1992-1994
Chemical Properties and Rules of Superconducting Oxides
Postdoctoral Fellowship Foundation of China (PI)
RMB $20,000
Previous
2001
Nanoparticle Based Photostimulated Luminescence Optical Storage
NSF-DMI-0060254-Phase-I (PI)
$100,000
Previous
2001
Immunoconjugate Luminescent Sensors Based on CdTe/CdS Nanoparticles
Energy transfer nanocomposite materials for in vivo radiation dosimetry and imaging
Wei Chen, Shaopeng Wang, Sarah Westcott, Jun Zhang, filed August 15, 2005 (0101P04)
Nanoparticle self-light photodynamic therapy
Wei Chen, filed September 3, 2004 (0102P04)
Nanoparticle Dose imaging and dosimetry
Wei Chen, Shaopeng Wang, Sarah Westcott, Jun Zhang, filed August, 2004 (0144U05)
Self-organizing one- dimensional assemblies of nanoparticles, nanorods, and nanowires
Nicholas A. Kotov, Wei Chen, Zhirong Tang, filed July 17, 2003 (60-3969-474)
Luminescent polymer nanoparticles
Larry Hancock Robert Dean, Wei Chen, November 30, 2001 (09-997-999)
Nanoparticle Thermometry and Pressure Sensing
Patent Home Page Wei Chen, Shaopeng Wang Sarah L. Westcott, filed June 12, 2002 (60-388-211)
Abstract A nanoparticle fluorescence (or upconversion) sensor comprises an electromagnetic source, a sample and a detector. The electromagnetic source emits an excitation. The sample is positioned within the excitation. At least a portion of the sample is associated with a sensory material. The sensory material receives at least a portion of the excitation emitted by the electromagnetic source. The sensory material has a plurality of luminescent nanoparticles luminescing upon receipt of the excitation with luminance emitted by the luminescent nanoparticles changing based on at least one of temperature and pressure. The detector receives at least a portion of the luminance emitted by the luminescent nanoparticles and outputs a luminance signal indicative of such luminance. The luminescence signal is correlated into a signal indicative of the atmosphere adjacent to the sensory material.
Upconversion luminescence of Mn-doped semiconductor nanoparticles
Patent Home Page Wei Chen filed June 6, 2001 (60-296-333) (issued)
Abstract The present relates in general to upconversion luminescence ("UCL") materials and methods of making and using same and more particularly, but not meant to be limiting, to Mn.sup.2+ doped semiconductor nanoparticles for use as UCL materials. The present invention also relates in general to upconversion luminescence including two-photon absorption upconversion, and potential applications using UCL materials, including light emitting diodes, upconversion lasers, infrared detectors, chemical sensors, temperature sensors and biological labels, all of which incorporate a UCL material.
Nanoparticles photostimulated luminescence based optical storage
Patent Home Page Wei Chen, filed August 17, 2001 (60-313-236) (issued)
Abstract The present invention relates in general to nanoparticles exhibiting luminescence such as photostimulated luminescence or photoluminescence and optical switching processes based upon such properties, in more particular, the use of such photostimulated luminescence exhibiting nanoparticles and switching nanoparticle for optical storage apparatuses and sensors as well as methods of making and using same.
Impact and Citations
Antigen/Antibody Immunocomplex from CdTe Nanoparticle Bioconjugates
Shaopeng Wang, Natalia Mamedova, Nicholas A. Kotov, Wei Chen, and Joel Studer, Nanoletters, 2002, 2(8): 817-822. Cited 82 times
Crystal Field, Phonon Coupling and Emission Shift of Mn2+ in ZnS:Mn Nanoparticles,
Wei Chen, R. Sammyneiken, Y. Huang, J-O Malm, R. Wallenberg, J-O Bovin, V. Zwiller and N. A. Kotov, J. Appl. Phys. 2001, 89 (2):1120-1129. Cited 52 times
Absorption and Luminescence of Surface States in ZnS Nanoparticles
Wei Chen, Zhangou Wang, Zhaojun Lin and Lanying Lin, J. Appl. Phys., 1997, 82(6):3111-3115. Cited 43 times
Energy Structure and Fluorescence of Eu2+ in ZnS:Eu2+ Nanoparticles
Wei Chen, Jan-Olle Malm, Valery Zwiller, Yining Huang, Shuman Liu, Reine Wallenberg, Jan-Olov Bovin and Lars Samuelson, Phys. Rev. B, 2000, 61(16): 11021-11024 Cited 42 times
Thermoluminescence of ZnS Nanoparticles
Wei Chen, Zhangou Wang,Zhaojun Lin and Lanying Lin, Applied Physics Letters, 1997, 70(11):1465-1467 Cited 36 times
Luminescence Enhancement of ZnS:Mn nanoclusters in Zeolite
Wei Chen, Ramaswasmi Sammyneiken, Yining Huang, J. Appl. Phys. 2000, 88 (9): 5188-5193. Cited 34 times
Photoluminescence and Photostimulated luminescence of Tb3+ and Eu3+ in Zeolite-Y
Wei Chen, Ramaswasmi Sammyneiken, Yining Huang, J. Appl. Phys. 2000, 88(3): 1424-1431 Cited 25 times
Temperature and Pressure Dependencies of the Mn2+ and the Donor-Acceptor Emissions in ZnS:Mn2+ Nanoparticles
Wei Chen, Fuhai Su, Guohua Li, Alan G. Joly, Jan-Olle Malm, and Jan-Olov Bovin, J. Appl. Phys. 2002,92(4):1950-1955 Cited 22 times
Characterization of CdSe Nanoclusters and CdSe/CdS Core/Shell Structure Synthesized in Aqueous Solution
Shuman Liu, Hai-Qing Guo, Zhi-Hua Zhang, Wei Chen, and Zhan-Guo Wang, Physica E, 2000, 8: 174-178 Cited 20 times
Some New Observation on the Formation and Optical Properties of CdS Clusters in Zeolite-Y
Wei Chen, Zhaojun Lin, Zhangou Wang, Jiajun Qian and Lanying Lin, Solid State Communications, 1996, 100(2): 101-104 Cited 20 times
Size-dependence of Eu2+ luminescence in ZnS:Eu Nanoparticles
Wei Chen, Jan-Olle Malm, Valery Zwiller, Reine Wallenberg, Jan-Olov Bovin, J. Appl. Phys. 2001, 89 (5): 2671-2675 Cited 20 times
Pressure Dependence of Mn2+ Fluorescence in ZnS:Mn Nanoparticles
Wei Chen Guohua Li, Jan-Olle Malm and Yining Huang, Hexian Han, Zhaoping Wang, J. Lumin, 2000, Vol.91, No.3-4, 139-145 Cited 19 times
Structure, Luminescence and Dynamics of Eu2O3 Nanoparticles in MCM-41
Wei Chen, Alan G. Joly, C. M. Kowalchuk, Jan-Olle Malm, Yining Huang and Jan-Olov Bovin, J. Phys. Chem.B , 2002, 106 (28):7034-7041 Cited 15 times
Voltage tunable electroluminescence of CdTe Nanoparticle light-emitting diodes
Wei Chen, Dennis Grouquist, and Joel Roark, Journal of Nanascience and Nanotechnology, 2002, 1 (1): 47-53 Cited 13 times
Optical Properties and Potential Applications of Doped Semiconductor Nanoparticles
Wei Chen, Jin Z. Zhang and Alan G. Joly, J. of Nanosci. and Nanotechnol. 2004, 4 (8): 919-947 Cited 13 times
Luminescence Enhancement of EuS Clusters in USY-Zeolite
Wei Chen, Xinhui Zhang, Yining Huang, Appl. Phys. Lett. 2000, 76 (17): 2328-2330 Cited 12 times
New observation on the luminescence of CdS clusters in zeolite-Y
Wei Chen, Zhangou Wang,Zhaojun Lin and Lanying Lin, Solid State Commun., 1997, 101(5):371-375 Cited 12 times
Formation, Structure and Fluorescence of CdS Clusters In A Mesoporous Zeolite
Wei Chen, Yan Xu, Zhaojun Lin, Zhanguo Wang, and Lanying Lin, Sol. Stat. Commun., 1998, 105(2): 129-134 Cited 12 times
Photostimuated Luminescence of AgI Clusters in Zeolite-Y
Wei Chen, Zhangou Wang,Zhaojun Lin, Lanying Lin, Keming Fang, Yan Xu, Mianzeng Su and Jianhua Lin, J. Appl. Phys., 1998, 83(7): 3811-3815 Cited 11 times
X-ray storage Phosphors, Their Properties and Mechanism
Mianzeng Su, Wei Zhao, Wei Chen, Yi Dong and Jinhua Lin, Journal of Alloys and Compounds, 1995, 225: 539-543 Cited 10 times
Additional Information
Awards
Distinguished young scientist award by the Chinese Academy of Sciences, October 13, 1997 Honor award of the 2nd class prize for the distinguished achievement in Science & Technology by State Education Commission of China, May, 1995 Honor award of the 2nd class prize for the achievement of Science & Technology by Peking University, Sept. 9,1994 Excellent graduate student award, Central-South University of Technology, 1986 Graduated with honor, Central-South University of Technology, 1988
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Faculty Profile
Mail Box: 40, CPB, Room No.: 214 
817-272-1064 
