Combining the simplicity of MALDI, the power of MSn, and the accuracy and resolution of TOF, the AXIMA Resonance provides researchers a unique solution to the next generation of structural and sequencing challenges. Designed without compromise, the AXIMA Resonance features high mass resolution and mass accuracy across MS and MSn analyses, excellent precursor ion selection, variable energy CID control on the fly, and outstanding sensitivity to ensure confident, high-quality results across a range of applications.
The unique combination of MALDI and QIT allows generation of ions using a number of different matrices; switching between positive and negative ionization modes in seconds; simple high resolution precursor ion selection for MSn experiments, and controllable MSn fragmentation. Incorporating a TOF analyzer promotes high resolution and high mass accuracy for all ions generated regardless of their origin.
Allows ions from complex mixtures or closely associated neighboring isotopic envelopes to be easily isolated and subsequently fragmented; trapping resolution greater than 1000 FWHM permits the analysis of samples with similar nominal mass
Once selected for fragmentation, precursor ions are
subjected to collision induced dissociation using argon as
the collision gas, whilst user defined collision energies are
allowed and may be varied on the fly.
Complete fragmentation is performed in the QIT. Ions are subsequently extracted to the flight tube incorporating a reflectron and detected by a high performance microchannel plate detector.
The QIT allows sequential dissociation of an ion via MSn experiments. This is particularly useful when analysing post translational modifications where MS2 is often not sufficient to determine both the nature and the location of the modification. Similarly, the composition of a glycan may be derived using MSn, detailing branched structures and cross ring cleavages to allow full interpretation of the structure.