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J.C. Chiao

Technology Meets Passion

Quite often these days, the defense industry or Homeland Security come calling on electrical engineering Professor J.C. Chiao for his specialty, radio frequency identification (RFID). Think tiny, wireless, battery-free sensors able to give readings almost instantaneously.

Great for military uses, perhaps weapons detection.

But while Dr. Chiao welcomes all kinds of applications, he’s especially excited about RFID in the lifesaving business.

“I’m convinced that RFID can achieve breakthroughs in the diagnosis and treatment of many medical conditions,” he says.

It’s that reasoning that prompts Chiao to attend workshops and lectures at UT Southwestern Medical Center at Dallas. It was there almost five years ago that he listened attentively to a talk by Shou-Jiang Tang, a clinician and assistant professor of internal medicine at UT Southwestern.

Dr. Tang studies the technology of examining the body’s canals, like the throat, stomach and colon. He researches gastroesophageal reflux disease, often called acid reflux, caused by stomach contents rising into the esophagus. Digestive acids can damage esophageal walls.

“The problem is surprisingly significant, particularly in developed countries,” Chiao said. “With it comes a dramatic increase in the incidence of esophageal cancer, statistically up about 350 percent in the U.S. and Europe over the past 25 years.”

A correlation exists between GERD and esophageal cancer. The American College of Gastroenterology estimates that 19 million people in this country alone have some degree of GERD.

“But now comes the snag,” Chiao said. “The current measurement systems are cumbersome and extremely unpopular with patients. To early-diagnose esophageal cancer from GERD symptoms, we need a simple and comfortable method to screen 19 million Americans.”

At the UT Southwestern lecture, Chiao heard Tang describe the way acid reflux in the esophagus is measured.

The doctor inserts a wire through the anesthetized patient’s nose and down the esophagus to the stomach opening. Electrodes at the tip of the wire measure acid coming up toward the throat.

“Imagine the discomfort of wired mechanisms through one’s nose-wires and electrodes that need to stay in place for 48 hours,” Chiao said.

Many patients are so conscious of the device that they stop regular eating, drinking, sleeping or work activities, which skews the measurements. Mobility is also limited.

“Early identification of esophageal cancer from GERD symptoms can save many lives,” Chiao notes. “But the key is to find the problem as early as possible. We have to find a better way of screening so people can be regularly tested in much the same way we encourage adults to get regular colon and breast cancer screening.”

Listening to the lecture, Chiao had a “eureka!” moment about the acid reflux measurement technology.

Why not replace the wired system with RFID?

He pitched the idea to Tang.

“He liked it,” Chiao said. “It made sense, and it would solve an important problem.”

An RFID chip receives radio transmissions, then uses that energy to retransmit information back to a receiver. Wal-Mart tracks inventory with RFID; it’s also used in smart credit cards. It has not been used with medical sensors. Not yet.

Chiao envisions pinning flexible RFID tags integrated with sensors to the esophagus, each tag smaller than a dime. When the esophageal wall scars, the tags drop into the stomach and pass through the digestive tract, or a physician can remove them.

As the sensors relay data wirelessly to a receiver outside the body, the receiver sends the data to a computer to be analyzed. The more data doctors collect, the more accurate their diagnosis.

It’ll also be a snap to quickly measure the effects of treatment procedures. Patients eventually will collect their own data on an iPod-sized device worn as a necklace or on the belt. The data can be stored in a memory card to be downloaded to a computer.

Tang is elated.

“Researchers (at UT Arlington) have already successfully tested the new RFID device to see that it properly identifies simulated stomach acids in a test tube and that the transmitter can send the results through human tissue,” he said in a recent issue of Science Daily. “Since the sensors are designed to detect stomach acid, gas and water, doctors can determine whether the presence of those substances coincides with feeling heartburn, the start of eating or other activities.”

Chiao gives much credit to his “brilliant” Ph.D. student, Thermpon Ativanichayaphong, and collaboration with Fred Tibbals, director of the Bioinstrumentation Resources Center at UT Southwestern, and Tang. The four have become good friends and often meet for lunch, which produces some highly technical conversations that one day may profoundly influence the research.

Inherently conservative, Chiao believes that clinical tests of the devices are still three years away from FDA approval. Physician Tang sees little risk for problems since the in vivo experiments showed great success.

Seven medical technology companies have expressed interest in funding various applications, Chiao says, and Texas Instruments has been financially supportive. The story has been covered by numerous local, national and international media outlets, and the team has received two international awards, including the Italian Well-Tech Award in 2009.

Chiao believes the results will be an eye opener.

“At the moment, there’s still not enough research being done combining RFID and sensor technologies. This is new not only for us, but the whole world.”

Chiao wants to do more of that blending of RFID/sensor technologies for medical purposes, starting with blocking chronic pain signals at the spinal cord using RFID implants. Experiments in rats have blocked pain signals by as much as 85 percent.

He and psychology Associate Professor Yuan Bo Peng, who is also a medical doctor specializing in pain study and neuroactivities, have received a National Science Foundation grant to study pain inhibition by wireless neurostimulation.

“The implications of RFIDs for this kind of use are enormous,” Chiao said. “They include treatment for diseases as varied as Parkinson’s tremor control, migraines, cancer and chemotherapy nerve damage pain, or any of hundreds of conditions involving chronic pain and the depression that often comes with it.”

Though the electrical engineer’s RFID research endeavors have been dominated by the military, he now sees a new venue and a new direction.

“What I love to do is medical research, to save people’s lives. It is my mission in life.”

Editor’s note: The full version of this article appears in the 2007 issue of UT Arlington’s Research magazine.

RFID sensor technologies

“The implications of RFIDs for this kind of use are enormous,” Chiao says. “They include treatment for diseases as varied as Parkinson’s tremor control, migraines, cancer and chemotherapy nerve damage pain, or any of hundreds of conditions involving chronic pain and the depression that often comes with it.”

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