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The University of Texas at ArlingtonThe University of Texas at Arlington


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CHEMISTRY & BIOCHEMISTRY

Junha Jeon

Junha Jeon

Associate Professor

Office: 203 Chemistry Research Building (CRB)
Email: junha.jeon@uta.edu
Phone: 817-272-0262
Research Page
Mentis Profile

Education:
B.S
Sungkyunkwan University, 2000
M.S. Sungkyunkwan University, 2002 (Chan-Mo Yu)
Ph.D. 
University of Minnesota, 2009 (Thomas R. Hoye)
Post Doctorate: University
 of Pennsylvania, 2009-2011 (Amos B. Smith)

Research



The primary field of study in my group at UT Arlington is chemical synthesis and catalysis. We target to develop direct, more efficient, streamlined synthetic methods to synthesize transformative molecules with significant functions. In order to achieve the goal, our strategy is to rationally design transition-metal/ligand catalyst complexes, to understand the function of the catalysts, and to utilize them for developing catalytic reaction methods. Specific areas of interest include transition metal-catalyzed hydrofunctionalization and dehydrogenative functionalization of unsaturated C–C bonds, catalytic C–H and C– C bond functionalization, and direct cross-coupling reactions.

Jeon research overview

We are also engaged in synthesis of chemically and biologically significant molecules including natural and unnatural molecules. The target-oriented synthetic study not only provides planned synthetic target molecules, but also often reveals new, unprecedented interesting reactivity and selectivity. We hope to apply the lessons from discovery of new reaction methods and synthesis of bioactive molecules into therapeutic areas.

Finally, we are currently engaged in to provide a new approach to design, fabricate, and characterize new nano-materials for energy-related fields.

Biography

Junha Jeon joined the University of Texas at Arlington in fall of 2011 as an assistant professor, and was recently promoted to an associate professor in 2017.  He completed a Bachelor’s (2000) and Master’s degrees (2002) in chemistry at the Sungkyunkwan University (SKKU) in South Korea in the laboratory of Professor Chan-Mo Yu, where he studied on catalytic enantioselective allylic transfer reactions.  He received Pre-Doctoral Graduate Research Fellowship from Korea Science and Engineering Foundation.  His doctoral research was then conducted under the guidance of Professor Thomas R. Hoye at the University of Minnesota (PhD in 2009).  Within the Hoye group, he focused on natural product synthesis and method development (Sequential Ring-Closing/Cross Metathesis strategy and Relay Ring-Closing Metathesis, RRCM).  The doctoral thesis title was “New Applications and Strategies in Olefin Metathesis: A Total Synthesis of (+)-Gigantecin and a Total Synthesis of (+)-Peloruside A”.  At UMN, he received Robert L. Ferm Outstanding Graduate TA Award (2005).  After completing his doctoral work, he joined the laboratory of Professor Amos B. Smith, III at the University of Pennsylvania as a Postdoctoral Fellow, where he continued to work on the natural product indole alkaloid synthesis.

At UTA, his current research program involves the chemical synthesis and catalysis and several interdisciplinary researches.  His recent recognition includes DFW Young Investigator, American Chemical Society-DFW Meeting (2014), Recipient of the Research Enhancement Proposal Grant of the UT Arlington (2014), ACS PRF Doctoral New Investigator (2015), Excellence in Teaching Award, The National Society of Leadership and Success, Sigma Alpha Phi UTA (2015), American Chemical Society (ACS) Young Organic Investigator, Young Academic Investigators symposium for the Fall 2016 ACS meeting in Philadelphia (2016), Outstanding Science Teaching Award for the College of Science (2017), President’s Award for Excellence in Teaching at UTA (2017), and UTA Interdisciplinary Research Program (IRP) Investigator (2018).

 

Publications

17.    “On-chip organic synthesis enabled by engine-and-cargo in an electrowetting-on-dielectric digital microfluidic device,” Torabinia, M.; Asgari, P.; Dakarapu, U. S. Jeon, J.*; Moon, H.* Lab on a Chip, Advanced Article.  DOI: 10.1039/c9lc00428a

16.    “Catalytic Hydrogen Atom Transfer from Hydrosilanes to Vinylarenes for Hydrosilylation and Polymerization,” Asgari, P.;§ Hua, Y.;§ Bokka, A.; Thiamsiri, C.; Prasitwatcharakorn, W.; Karedath, A.; Leem, K.; Sardar, S.; Yum. K.; Pierce, B.; Nam, K.; Gao, J.; Jeon, J.*  Nature Catalysis, 2019, 2, 164-173.  (§equal contribution)  http://dx.doi.org/10.1038/s41929-018-0217-z.

                  –A short essay, “Catalytic hydrogen atom transfer from hydrosilanes to vinylarenes–Alkali metal Lewis base catalysed hydrosilylation and polymerization” in "Behind the paper" in NatureResearch Chemistry.

15.    “Umpolung a-Silylation of Cyclopropyl Acetates via Low Temperature Catalytic C–C Activation,” Avullala, T.; Asgari, P.; Hua, Y.; Ridlen, S.; Yum, K.; Dias, R.; Jeon, J.* ACS Catalysis, 2019, 9, 402–408. DOI: 10.1021/acscatal.8b04252

14.    "3D Printing of Anisotropic Hydrogels with Bioinspired Motion," Hakan Arslan, Amirali Nojoomi, Junha Jeon, Kyungsuk Yum* Advanced Science, 2019, 6, 1800703. DOI: 10.1002/advs.201800703.

13.    “Asymmetric Synthesis of Remote Quaternary Centers by Copper-Catalyzed Desymmetrization: An Enantioselective Total Synthesis of (+)-Mesembrine,” Bokka, A.; Mao, J.; Hartung, J.; Martinez, S.; Simanis, J.; Nam, K.; Jeon, J.;* Shen, X.* Org. Lett. 2018, 20, 5158–5162. DOI: 10.1021/acs.orglett.8b02084.

                  –Highlighted in Synfacts, 2018, 14, 1158 by Mark Lautens and José F. Rodríguez. DOI: 10.1055/s-0037-1611080.

12.    "Near-Infrared Fluorescence Modulation of Refolded DNA Aptamer-Functionalized Single-Walled Carbon Nanotubes for Optical Sensing," Lee, Kwan; Nojoomi, Amirali; Jeon, Junha; Lee, Chang Young; Yum, Kyungsuk* ACS Appl. Nano Mater. 2018, 1, pp 5327–5336. DOI: 10.1021/acsanm.8b01377.

11.    “Aryne Cycloaddition Reactions of Benzodioxasilines as Aryne Precursors Generated by Catalytic Reductive ortho-C–H Silylation of Phenols with Traceless Acetal Directing Groups,” Asgari, P.; Dakarapu, U. S.; Nguyen, H. H.; Jeon, J.* Tetrahedron 2017, 73, 4052-4061. [Invited to Symposium-in-Print for Tetrahedron (New Advances in Pericyclic Reactions)]. PMID: 28694551; PMCID: PMC5501486; DOI: 10.1016/j.tet.2016.12.002.

10.    “Enhanced Thermophysical Properties via PAO-Superstructure,” Pournorouz, Z.; Mostafavi, A.; Pinto, A.; Bokka, A.; Jeon, J.; Shin, D.* Nanoscale Res. Lett. 2017, 12, 29.  PMID: 28078609; PMCID: PMC5226906; DOI 10.1186/s11671-016-1802-1. PMID: 28078609; PMCID: PMC5226906; DOI: 10.1186/s11671-016-1802-1.

9.      “Regio- and Stereoselective Dehydrogenative Silylation and Hydrosilylation of Vinylarenes Catalyzed by Ruthenium Alkylidenes,” Bokka, A.; Jeon, J.* Org. Lett. 2016, 18, 5324–5327.  PubMed PMID: 27732000; DOI: 10.1021/acs.orglett.6b02642.

8.      “Catalytic Reductive ortho-C–H Silylation of Phenols with Traceless, Versatile Acetal Directing Groups and Synthetic Applications of Dioxasilines,” Hua, Y.;§ Asgari, P.;§ Avullala, T.; Jeon, J.* J. Am. Chem. Soc. 2016, 138, 7982–7991. (§equal contribution) PubMed PMID: 27265033; PMCID510341; DOI: 10.1021/jacs.6b04018.

7.      "Gold-Mediated Isomerization of Cyclooctyne to Ring-Fused Olefinic Bicycles," Das, A.; Hua, Y.; Yousufuddin, M.; Cundari, T. R.;* Jeon, J.;* Dias, H. V. R.* Eur. J. Inorg. Chem. 2016, 995-1001. DOI: 10.1002/ejic.201600021.

6.      “Lewis Base Activation of Silyl Acetals: Application to Reductive Horner-Wadsworth-Emmons Olefination,” Dakarapu, U. S.; Bokka, A.; Asgari, P.; Trog, G.; Hua, Y.; Nguyen, H. H.; Raman, N.; Jeon, J.* Org. Lett. 2015, 17, 5792-5795. PubMed PMID: 26566189; DOI: 10.1021/acs.orglett.5b02901.

                  –Highlighted in Organic Chemistry Portal: http://www.organic-chemistry.org/abstracts/lit5/200.shtm

5.      “Mechanistic Insights into Grubbs-Type Ruthenium Complex-Catalyzed Intramolecular Alkene Hydrosilylation: Direct s-Bond Metathesis in the Initial Stage of Hydrosilylation,” Bokka, A.; Hua, Y.; Berlin, A. S.; Jeon, J.* ACS Catal. 2015, 5, 3189−3195. DOI: 10.1021/acscatal.5b00431.

4.      “Modular Approach to Reductive Csp2–H and Csp3–H Silylation of Carboxylic Acid Derivatives through Single-Pot, Sequential Transition Metal Catalysis,” Hua, Y.; Jung, S.; Roh, J.; Jeon, J.* J. Org. Chem. 2015, 80, 4661-4671. PubMed PMID: 25853682; DOI: 10.1021/acs.joc.5b00564.

                  –Highlighted in Organic Chemistry Portal by Professor Taber on Preparation of Substituted Benzenes, 2015, October 12.

3.      “Reductive ortho-Silanolization of Aromatic Esters with Hydridosilyl Acetals,” Hua, Y.; Asgari, P.; Dakarapu, U. S.; Jeon, J.* Chem. Commun. 2015, 51, 3778-3781. PubMed PMID: 25646601; DOI: 10.1039/c4cc09850a.

                  –Highlighted in Organic Chemistry Portal by Professor Taber on Preparation of Substituted Benzenes, 2015, October 12.

2.      “Rhodium-Catalyzed Alkene Hydrosilylation via a Hydride Shuttle Process by Diene Ligands: Dramatic Enhancement of Regio- and Diastereoselectivity,” Hua, Y; Nguyen, H. H.; Trog, G.; Berlin, A. S.; Jeon, J.* Eur. J. Org. Chem. 2014, 5890-5895. PubMed PMID: 23773003; DOI: 10.1002/ejoc.201402742.

                  –Highlighted in Synfacts, 2014, 10, 1297 by Hisashi Yamamoto and Atsuto Izumiseki. DOI: 10.1055/s-0034-1379590.

1.      “Ligand-Controlled, Norbornene-Mediated, Regio- and Diastereoselective Rhodium-Catalyzed Intramolecular Alkene Hydrosilylation Reactions,” Hua, Y; Nguyen, H. H.; Scaggs, W. R.; Jeon, J.* Org. Lett. 2013, 15, 3412-3415. PubMed PMID: 23773003; DOI: 10.1021/ol401464n.

Prior to Independent Career Publications  (authors listed in publications 2-5 alphabetically)

5.      “Allylmalonate as an Activator Subunit for Initiation of Relay Ring-Closing Metathesis (RRCM) Reactions,” Hoye, T. R.*; Jeon, J.; Tennakoon, M. A. Angew. Chem., Int. Ed. 2011, 50, 2141-2143.  PubMed PMID: 21344570; PMCID: PMC3056160; DOI: 10.1002/anie.201005044.

4.      “Total Synthesis of Peloruside A through Kinetic Lactonization and Relay Ring-Closing Metathesis Cyclization Reactions,” Hoye, T. R.*; Jeon, J.; Kopel, L. C.; Ryba, T. D.; Tennakoon, M. A.; Wang, Y. Angew. Chem., Int. Ed. 2010, 49, 6151-6155.  PubMed PMID: 20645374; PMCID: PMC3740187; DOI: 10.1002/anie.201002293.

         –Highlighted in Synfacts, 2010, 1331.

3.      Hoye, T. R.*; Jeon, J. “Metathesis Involving a Relay and Applications in Natural Product Synthesis. In Metathesis in Natural Product Synthesis. Strategies, Substrates and Catalysts,” Cossy, J.; Arseniyadis, S.; Meyer, C. Eds.; Wiley-VCH: Weinheim, 2010, Chapter 9, pp 261-285. DOI: 10.1002/9783527629626.ch9.

2.      “Sequencing of Three-Component Olefin Metatheses: Total Synthesis of Either (+)-Gigantecin or (+)-14-Deoxy-9-oxygigantecin,” Hoye, T. R.*; Eklov, B. M.; Jeon, J.; Khoroosi, M. Org. Lett. 2006, 8, 3383-3386. PubMed PMID: 16836411; DOI: 10.1021/ol061383u.

         –Highlighted in Synfacts, 2007, 9.

1.      “Catalytic Asymmetric Allylic Transfer Reaction for the Enantioselective Synthesis of Dienyl and Enynyl Alcohol.” Yu, C.-M.*; Jeon, M.; Lee, J.-Y.; Jeon, J.Eur. J. Org. Chem. 2001, 1143-1148.


Complete List of Published Work in My Bibliography (via ncbi): http://www.ncbi.nlm.nih.gov/myncbi/junha.jeon.1/bibliography/48219556/public/?sort=date&direction=ascending

Awards


Outstanding Science Teaching Award for the College of Science (2017)

The President’s Award for Excellence in Teaching (2017)

American Chemical Society (ACS) Young Organic Investigator, Young Academic Investigators symposium for the Fall 2016 ACS meeting in Philadelphia (2016)

Excellence in Teaching Award, The National Society of Leadership and Success, Sigma Alpha Phi UTA (2015)

ACS PRF Doctoral New Investigator (2015)

Recipient of the Research Enhancement Proposal Grant of the UT Arlington (2014)

University of Minnesota, Department of Chemistry, Robert L. Ferm Outstanding Graduate TA Award (2005).

Korea Science and Engineering Foundation Pre-DoctoralGraduate Fellowship (2003).