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The University of Texas at ArlingtonThe University of Texas at Arlington


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CHEMISTRY & BIOCHEMISTRY

Byung Ran (Ranny) So

He Dong

Assistant Professor

Office: 350 Chemistry Physics Building (CPB)
Email: byungran.so@uta.edu
Phone:817 272 9865 
Mentis Profile


Education:
B.S. Sungkyunkwan University, 2000
M.S. Sungkyunkwan University, 2002 
Ph.D. Ohio State University, 2010 
Post Doctorate: 
University of Pennsylvania, 2010-2020 (Gideon Dreyfuss)

Research Interests:

RNA-Protein complexes,
gene regulation,
macromolecular complex assembly and function



Current Research:

The focus of my research is to understand how RNA-protein complexes play a role in coding and non-coding gene expression using a various research tools including biochemistry, molecular/cell, and structural biology. Current research topics are 1) biogenesis of non-coding small nuclear RNAs; 2) interconnection between splicing and cleavage and polyadenylation machineries in coding gene processing; 3) perturbation of RNA processing and its link to diseases.

 

Biography

Byung Ran (Ranny) So joined the University of Texas at Arlington in Sep 2020. Dr. So received her Ph.D. degree in biological chemistry at the Ohio State University in 2010 under the guidance of Professor Karin Musier-Forsyth. She conducted her postdoctoral training with Professor Gideon Dreyfuss (National Academy of Sciences) in the Department of Biochemistry and Biophysics at the School of Medicine, at the University of Pennsylvania /Howard Hughes Medical Institute (HHMI). Her multidisciplinary research centered on RNA-Protein complexes spans from synthetic organic chemistry to biochemistry, molecular biology, and drug discovery to elucidate underlying non-coding RNA-protein complex mediated mechanisms in post-transcriptional gene regulation and translational quality control.


Publications:

  1. So B.R., Dreyfuss G. 2019. Myriad RNAs and RNA-binding proteins control cell functions, explain diseases, and guide new therapies. Cold Spring Harbor Symp Quant Biol 84, (in press). doi:10/1101/sqb.2019.84.040469
  2. Di C*, So B.R.*, Cai Z, Arai C, Duan J, Dreyfuss G. 2019. U1 snRNP telescripting roles in transcription and its mechanism. Cold Spring Harbor Symp Quant Biol 84, (in press). doi:10/1101/sqb.2019.84.040451 *co-authors
  3. Oh, J.; Venters, C.; Di, C.; Pinto, A.M.; Wan, L.; Younis, I.; Arai, C; Cai, Z.; So, B.R.; Dreyfuss, G. U1 snRNP regulates cancer cell migration and invasion. Nature Communications 11, 1-7 (2020).
  4. So, B.R.; Di, C.; Cai, Z.; Venters, C.; Guo, J.; Oh, J.; Arai, C; Dreyfuss, G. A complex of U1 snRNP with cleavage and polyadenylation factors controls telescripting, regulating mRNA transcription in human cells. Molecular Cell, 76, 590-599 (2019).
  5. Venters, C.C., Oh, J.-M., Di, C., So, B.R., and Dreyfuss, G. U1 snRNP Telescripting: suppression of premature transcription termination in introns as a new layer of gene regulation. In: Cech, T.R., Steitz, J.A., and Atkins, J.F., eds., Cold Spring Harbor Perspectives in Biology. Cold Spring Harbor Laboratory Press, 2019; 11: a032235
  6. Chen, L.; Tanimoto, A.; So, B.R.; Bakhtina, M.; Magliery, T.J.; Wysocki, V.; and Musier-Forsyth, K. Stoichiometry of triple-sieve tRNA editing complex ensures fidelity of aminoacyl-tRNA formation. Nucleic Acids Research, 47, 929-940 (2019).
  7. Oh, J.-M.; Di, C.; Venters, C.; Guo, J.; Arai, C.; So, B.R.; Pinto, A.M.; Zhang, Z.; Wan, L.; Younis, I.; Dreyfuss, G. U1 snRNP telescripting regulates size-function stratified human genome, Nature Structural & Molecular Biology, 24, 993-999 (2017)
  8. So, B.R., Zhang, Z. and Dreyfuss, G. The Function of Survival Motor Neuron Complex and Its Role in Spinal Muscular Atrophy Pathogenesis. In: Sumner. C.J., Paushkin, S., Ko, C.-P., eds., Spinal Muscular Atrophy: Disease Mechanisms and TherapySan Diego: Academic Press, 2017: 99-111.
  9. So, B.R.; Wan, L.; Zhang, Z.; Li, P.; Babiash, E.; Duan, J.; Younis, I.; Dreyfuss, G.A U1 snRNP-Specific Assembly Pathway Reveals SMN-Gemin2 as a Versatile hub for RNP Exchange Nature Structural & Molecular Biology, 23, 225-230 (2016)
  10. Zhang, R.; So, B.R.*; Li, P.*; Yong, J.; Glisovic, T.; Wan, L.; Dreyfuss, G. Structure of a Key Intermediate of the SMN complex Reveals Gemin2’s Crucial Function in snRNP Assembly Cell, 146, 384-395 (2011). *co-authors
  11. So, B.R.; An, S.; Kumar, S.; Das, M.; Turner D. A.; Hadad, C. M.; Musier-Forsyth, K. Substrate-Mediated Fidelity Mechanism Ensures Accurate Decoding of Proline Codons Journal of Biological Chemistry, 286, 31810-31820 (2011).
  12. Ling, J.; So, B.R.; Yadavalli, S. S.; Roy, H.; Shoji, S.; Fredric, K.; Musier-Forsyth, K.; Ibba, M. Resampling and Editing of Mischarged tRNA Prior to Translation Elongation Molecular Cell, 33, 654-660 (2009).
  13. Lee, K.-W.; Hwang, S.-R.; Kim, C.-R.; Nam, D.-H.; Chang J.-H.; Choi, S.-C.; Choi, B.-S.; Choi, H.-W.; Lee, K.-K.; So, B.-R.; Cho, S.-W.; Shin, H.-Y. The Chemical Development of LB71350 Organic Process Research & Development, 7, 839-845 (2003).
  14. Yu, C.-M.; Lee, J.-Y.; So, B.R.; Hong, J. Sequential Catalytic Asymmetric Allylic Transfer Reaction: Enantioselective and Diastereoselective Construction of Tetrahydropyran Units Angewandt Chemie International Edition, 41, 161-163 (2002).