Sympathetic Vascular Transduction
Aside from quantifying sympathetic nerve firing, we also are interested in assessing how sympathetic nerve activity is transduced into a blood pressure response. For this, a signal-averaging approach to sympathetic transduction has been utilized extensively in our lab. Specifically, each "burst" of sympathetic outflow (depicted below) is tracked for 10-15 heart beats and associated with the corresponding blood pressure changes over that time period. In addition, blood flow (see other techniques) is also used, to track how sympathetic outflow decreases blood flow over 15 heart beats (i.e. vasoconstriction). The activity is then further characterized to provide insight into how different burst patterns and sizes affect blood pressure and blood flow.