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College of Nursing and Health Innovation | The University of Texas at ArlingtonCollege of Nursing and Health Innovation | The University of Texas at Arlington


Touching Lives. Transforming Health Care.

Pan Lab - Publications, Complete List

Complete list of Full Papers in Peer-Reviewed Journals (in chronological order):

  1. Tan C, Gu L, Pan Z. 组合式数显直读光栅光谱仪 (Digital Composite Grating Spectrometer). Physics Experimentation (Chinese) 1993; 04: 27-28
  2. Guo M, Pan Z and Wang H. Establishment of Hybridoma Secreting anti-Mycobacteria Monoclonal Antibody by using Electrofusion Technique. Microbiology Acta (Chinese) 1998; 38(5): 393-395
  3. Pan Z and Chen J. A Mechanism Underlying Stimulation and Inhibition of Protein Kinase C by LysoPC: A Role of Membrane Physical State.  Science in China (Series C) 1998; 41(6): 584-591
  4. Jiang J, Pan Z, Chen J and Huang F. Interaction Between PKC and Sphingomyelin/ Cholesterol.  Cell Biology International 1999; 23(7): 457-463
  5. Jiang Y, Pan Z, Chen J, and Huang F. Purification Caveolae from Mouse Lungs with Non-detergent Method. Science Bulletin (Chinese) 1999; 44(3): 403-407
  6. Hayek SM, Zhao J, Bhat M, Xu X, Nagaraj R, Pan Z, Takeshima H, Ma J. The negatively charged region of the skeletal muscle ryanodine receptor is involved in Ca2+-dependent regulation of the Ca2+ release channel. FEBS Letters. 1999; 461: 157-164
  7. Pan Z, Damron D, Nieminen AL, Bhat MB, Ma J. Depletion of Intracellular Ca2+ by Caffeine and Ryanodine Induces Apoptosis of Chinese Hamster Ovary Cells Transfected with Ryanodine Receptor. J. Biol. Chem. 2000; 275(26): 19978-19984
  8. Pan Z, Bhat MB, Nieminen AL, Ma J. Synergistic movements of Ca2+ and Bax in cells undergoing apoptosis. J. Biol. Chem. 2001; 276: 32257-32263  
  9. Yang D, Pan Z, Takeshima H, Wu C, Nagaraj RY, Ma J, Cheng H. RyR3 amplifies RyR1-mediated Ca2+-induced Ca2+ release in neonatal mammalian skeletal muscle. J. Biol. Chem. 2001; 276: 40210-40214
  10. Shin DW, Pan Z, Bandyopadhyay A, Bhat MB, Kim DH, Ma J. Calcineurin-Dependent Dephosphorylation of Ryanodine Receptor Down-Regulates Activity of the Ca2+ Release Channel in Skeletal MuscleBiophys. J. 2002; 83 (11): 2539-2549.
  11. Pan Z, Yang D, Nagaraj RY, Nosek TA, Nishi M, Takeshima H, Cheng H, Ma J.  Deletion of mg29 gene leads to defective function of store-operated Ca2+ channel in skeletal muscle. Nature Cell Biology. 2002; 4(5) 379-383
  12. Shin DW, Pan Z, Kim EK, Lee JM, Bhat MB, Parness J, Kim DH, Ma J. A Retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle. J. Biol. Chem. 2003, 278: (5): 3286-3292
  13. Ma J and Pan Z. Junctional Membrane Structure and Store-Operated Calcium Entry in Muscle Cells. Front. Biosci. 2003, 8(1): d242-d255 (review article)
  14. Ma J and Pan Z. Retrograde activation of store-operated calcium channel. Cell Calcium. 2003, 33: 375–384 (review article)
  15. Brostrom M, Pan Z, Meiners S, and Brostrom CO. Calcium signaling induced by thrombin in H9c2 heart-derived myocytes. Int. J. Biochem. Cell Biol. 2003, 35: 1573–1587
  16. Zhou F, Tanaka K, Pan Z, Ma J, You G. The role of glycine residues in the function of human organic anion transporter 4 (hOAT4). Molecular Pharmacology. 2004, 65(5):1141-1147
  17. Pan Z, Hirata Y, Nagaraj RY, Zhao J, Nishi M, Hayek SM, Bhat MB, Takeshima H, Ma J. Co-expression of mg29 and ryanodine receptor leads to apoptotic cell death - effect mediated by intracellular Ca2+ release. J. Biol. Chem. 2004; 279: 19387 - 19390 (accelerated publication)   
  18. Nur-E-Kamal A, Gross SR, Pan Z, Balklava Z, Ma J, Liu LF. Nuclear Translocation of Cytochrome c During Apoptosis. J. Biol. Chem. 2004; 279: 24911-24914.
  19. Zhou F, Pan Z, Ma J, You G. Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochem J. 2004; 384(Pt 1):87-92.
  20. Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G. The role of N-linked glycosylation in protein folding, membrane targeting and substrate binding of human organic anion transporter hOAT4. Mol Pharmacol. 2005; 67(3):868-76
  21. Wang X, Weisleder N, Collet C, Zhou J, Chu Y, Hirata Y, Zhao X, Pan Z, Brotto M, Cheng H, Ma J. Uncontrolled calcium sparks as dystrophic signal for mammalian skeletal muscle. Nature Cell Biology 2005; 7(5): 525-30
  22. Lin PH, Pan Z, Zheng L, Li N, Danielpour D, Ma JJ. Overexpression of Bax sensitizes prostate cancer cells to TGF-beta induced apoptosis. Cell Res. 2005; 15(3):160-6. 
  23. Uzumcu, M, Pan Z, Chu Y, Kuhn PE, Zachow RJ. Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat granulosa cells in vitro. Reproduction 2006; 132(2):291-9.
  24. Ju J, Hong J, Zhou JN, Pan Z, Bose M, Liao J, Yang GY, Liu YY, Hou Z, Lin Y, Ma J, Shih WJ, Carothers AM, Yang CS. Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res. 2005; 65(22): 10623-31.
  25. Weisleder N., Brotto M., Komazaki, S., Pan, Z., Nosek, T., Parness, J., Takeshima H, and Ma J. Aged skeletal muscle displays compromised Ca sparks and segregated intracellular Ca release. J. C. Biol. 2006; 174(5): 639-45.
  26. Ko J., Choi K., Pan Z., Lin P., Kim C.W., Ma J. Tail-anchoring domain of Bfl-1 targets mitochondria and induces apoptosis by its amphipathic property. J. Cell Sci. 2007, 120(Pt 16):2912-23
  27. Zhao X, Weisleder N, Han X, Pan Z, Parness J, Brotto M, Ma J. Azumolene inhibits a component of store-operated calcium entry that is coupled to the skeletal muscle ryanodine receptor. 2006; J Biol Chem. 2006; 281(44): 33477-86
  28. Hirata Y, Brotto M, Weisleder N, Chu Y, Lin P, Zhao X, Thornton A, Komazaki S, Takeshima H, Ma J, Pan Z. Uncoupling of store-operated Ca2+ entry through silencing of junctophilin genes. Biophysical J.  2006; 90(12): 4418-27
  29. Cai C, Lin P, Cheung KH, Li N, Levchook C, Pan Z, Ferrante C, Boulianne GL, Foskett JK, Danielpour D, Ma J. The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. J Biol Chem. 2006; 281(24):16649-55
  30. Yuan X, Xu C, Pan Z, Keum YS, Kim JH, Shen G, Yu S, Oo KT, Ma J, Kong AN. Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Mol Carcinog. 2006; 45(11):841-50.
  31. Xu C, Yuan X, Pan Z, Shen G, Kim J, Yu S, Khor T, Li W, Ma J, Kong AN. Mechanism of action of isothiocyarates: the induction of ARE-regulated genes is associated with activation of ERK and JND. Molecular Cancer Therapeutics. 2006; 5(8): 1918-26
  32. Devadas S, Das J, Liu C, Robert A, Zhang L, Pan Z, Moore PA, Das G, Shi Y. Granzyme B Is Critical for T Cell Receptor-Induced Cell Death of Type 2 Helper T Cells. Immunity. 2006; 25(2): 237-47
  33. Hong M, Tanaka K, Pan Z, Ma J, You G. Determination of the external loops and the cellular orientation of the amino- and the carboxyl termini of the human organic anion transporter hOAT1. Biochem J. 2007 401(2):515-20
  34. Landstrom AP, Weisleder N, Batalden KB, Martijn Bos J, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J. Mol. Cell. Cardiol. 2007; 42(6): 1026-35
  35. Yazawa M, Ferrante C, Feng J, Mio K, Ogura T, Zhang M, Lin PH, Pan Z, Komazaki S, Kato K, Nishi M, Zhao X, Weisleder N, Sato C, Ma J, Takeshima H. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature. 2007; 448(7149): 78-82.
  36. Li X, Perez L, Pan Z, Fan H. Role for the transmembrane domain of TACE in protein ectodomain shedding.  Cell Res.  2007, 17(12):985-998
  37. Li N, Zheng L, Lin P, Danielpour D, Pan Z, Ma J. Overexpression of Bax Induces Down-Regulation of Store-Operated Calcium Entry in Prostate Cancer Cells. J. Cell. Physiology. 2008 216(1): 172-9
  38. Cai C, Masumiya H, Weisleder N, Nishi M, Komazaki S, Ko JK, Lin P, Thornton A, Pan Z, Brotto M, Takeshima H and Ma J. MG53 nucleates assembly of cell membrane repair machinery. Nature Cell Biology, 2009 11(1):56-64
  39. Zhang Q, Hong M, Duan P, Pan Z, Ma J, and You G. Organic Anion Transporter OAT1 Undergoes Constitutive and Protein Kinase C-regulated Trafficking Through a Dynamin- and Clathrin-dependent Pathway. J. Biol. Chem. 2008 283(47):32570-9
  40. Li Na, Lin P, Cai C, Pan Z, Weisleder N and Ma J. The amino-terminal peptide of Bax perturbs intracellular Ca homeostasis to enhance apoptosis in prostate cancer cells. AJP: Cell Physiology, 2009 296(2):C267-72
  41. Pachikara N, Zhang H, Pan Z, Jin S, Fan H. Productive Chlamydia trachomatis lymphogranuloma venereum 434 infection in cells with augmented or inactivated autophagic activities. FEMS Microbiol Lett. 2009 292(2):240-9.
  42. Cai C, Masumiya H, Weisleder N, Pan Z, Nishi M, Komazaki S, Takeshima H, Ma J. MG53 regulates membrane budding and exocytosis in muscle cells. J Biol Chem. 2009 284(5):3314-22
  43. Cai SQ, Wang Y, Park KH, Tong X, Pan Z, Sesti F. Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning. EMBO J. 2009; 28(11):1601-11.
  44. Calcraft PJ^, Ruas M^, Pan Z^, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature, 2009, 459(7246):596-600    ^equal contribution
  45. Zimering M, Pan Z. Auto-antibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells. J Clin Endocrinol Metab, 2009, 94(6):2171-7
  46. Zhang Q, Pan Z, You G. Regulation of human organic anion transporter 4 by protein kinase C and NHERF-1: altering the endocytosis of the transporter. Pharm Res. 2010, 27(4):589-96.
  47. Ebert EC, Geng X, Bajpai M, Pan Z, Tatar E, Das KM. Antibody to tropomyosin isoform 5 and complement induce the lysis of colonocytes in ulcerative colitis. Am J Gastroenterol. 2009, 104(12):2996-3003
  48. Zhu H, Yue J, Pan Z, Wu H, Cheng Y, Lu H, Ren X, Yao M, Shen Z, Yang J. Involvement of Caveolin-1 in Repair of DNA Damage through both Homologous Recombination and Non-Homologous End Joining. PloS One, 2010. Aug 6;5(8):e12055.
  49. Cheung KL, Yu S, Pan Z, Ma J, Wu TY, Kong AN. tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and Polymerase-II to promoter region of HO-1. Chem Res Toxicol. 2011. 24(5):670-6.
  50. Ko JK, Choi KH, Zhao X, Komazaki S, Pan Z, Weisleder N, Ma J. A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice. FASEB J. 2011. 25(8):2638-49
  51. Thornton AM, Zhao X, Weisleder N, Brotto L, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M. Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle. Aging. 2011. 3(6):621-34.
  52. Zhao X, Yamazaki D, Kakizawa S, Pan Z, Takeshima H, Ma J. Molecular architecture of Ca ( 2+) signaling control in muscle and heart cells. Channels (Austin). 2011. 5(5):391-6
  53. Zimering M, Alder J, Pan Z, Donnelly RJ. Endothelial cell inhibitory auto-antibodies are associated with painful neuropathy in adult type 2 diabetes. Diabetes Res Clin Pract. 2011 93(1):95-105
  54. Yasir M, Pachikara ND, Bao X, Pan Z, Fan H. Regulation of Chlamydial Infection by Host Autophagy and Vacuolar ATPase-bearing Organelles. Infect Immun. 2011. 79(10):4019-28
  55. Zhang Q, Wu J, Pan Z, You G. The Role of Dileucine in the Expression and Function of Human Organic Anion Transporter 1 (hOAT1). Int J Biochem Mol Biol. 2011, 2(1):31-38
  56. Heck B, Zhang B, Pan Z, Deng W-M, Tsai C. The transcriptional co-repressor SMRTER differentially regulates ecdysone and Notch signaling in Drosophila. Biol Open. 2012 Mar 15;1(3):182-96. doi: 10.1242/bio.2012047.
  57. Lin P, Zhu H, Cai C, Wang X, Cao C, Xiao R, Pan Z, Weisleder N, Takeshima H and Ma J. Non-muscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. FASEB J, 2012, 26(5):1875-83
  58. Pan Z*, Zhao X, Brotto M. Fluorescence-Based Measurement of Store-Operated Calcium Entry in Live Cells --- from Cultured Cancer Cell to Skeletal Muscle Fiber. J Vis Exp. 2012 Feb 13;(60). pii: 3415. doi: 10.3791/3415. * Corresponding author
  59. Cotella D, Enriquez BH, Wu X, Li R, Pan Z, Leveille J, Link C, Oddo S and Sesti F. Toxic role of K+ channel oxidation in mammalian brain. J Neuroscience. 2012, 32(12): 4133-44.
  60. Zhang Q, Suh W, Pan Z, You G. Short-term and long-term effects of protein kinase C on the trafficking and stability of human organic anion transporter 3. Int J Biochem Mol Biol. 2012; 3(2): 242-9.
  61. Tjondrokoesoemo A, Li N, Lin PH, Pan Z, Ferrante CJ, Shirokova N, Brotto M, Weisleder N, Ma J. Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium sparks signaling in adult mammalian skeletal muscle. J. Biol. Chem. 2013, 288(4): 2103-9.
  62. Yan Y, Zhou X, Pan Z, MA J, Waschek J, and DiCicco-Bloom E. Pro- and Anti-Mitogenic Actions of PACAP in Developing Cortex: Potential Mediation by Developmental Switch of PAC1 Receptor mRNA Isoforms. J Neuroscience. 2013, 33(9): 3865-78.
  63. Pan Z*, Brotto M, Ma J*. Store-Operated Ca2+ in skeletal muscle and heart: Physiology and Pathophysiology. BMB Reports. 2014, 47(2):69-79. (review article) * Corresponding author
  64. Zhu H, Zhang H, Jin F, Fang M, Huang M, Yang CS, Chen T, Fu LW, Pan Z*. The oncogenic role of Orai1 through enhanced intracellular Ca2+ oscillations in esophageal squamous carcinoma. Oncotarget. 2014, 5(11):3455-71. * Corresponding author
  65. Pan Z*, Ma J*. Open Sesame: treasure in store operated calcium entry pathway for cancer therapy. Science China Life Science. 2015, 58(1): 48-53. *Corresponding author
  66. Shi N, Jin F, Clinton SK, Zhang X, Pan Z, Chen T. Human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis. Oncotarget. 2014, 5(22):11333-44.
  67. Sopariwala DH, Pant M, Shaikh SA, Goonasekera SA, Molkentin JD, Ma J, Pan Z and Periasamy M. Sarcolipin overexpression improves muscle energetics and reduces fatigue. J Appl Physiol (1985). 2015, 118(8):1050-8.
  68. Shi N, Clinton SK, Liu Z, Wang Y, Riedl KM, Schwartz SJ, Zhang X, Pan Z, Chen T. Strawberry Phytochemicals Inhibit Azoxymethane/Dextran Sodium Sulfate-Induced Colorectal Carcinogenesis in Crj: CD-1 Mice. Nutrients. 2015, 7(3):1696-1715. doi: 10.3390/nu7031696.
  69. Cai C, Lin PH, Zhu H, Ko JK, Hwang M, Tan T, Pan Z, Korichneva I, and Ma J. Zinc Binding to MG53 Facilitates Repair of Injury to Cell Membrane. J. Biol. Chem. 2015, 290(22):13830-9.
  70. Xu D, Wang H, Gardner C, Pan Z, Zhang PL, Zhang J, You G. The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1. Am J Physiol Renal Physiol. 2016, 311(2):F320-9. doi: 10.1152/ajprenal.00153.2016.
  71. Pan Z*, Choi S, Ouadid-Ahidouch H, Yang J, Beattie JH, Korichneva I. Zinc transporters and dysregulated channels in cancers. Frontiers in Bioscience, Landmark, 2017, 22, 623-643. [DOI No:10.2741/4507] *Corresponding author.
  72. Cui C, Merritt R, Fu L, Pan Z*. Targeting Calcium Signaling in Cancer Therapy. Acta Pharmaceutica Sinica B, 2016 (accepted). *Corresponding author.
  73. Choi S, Liu X, Pan Z. Zinc Deficiency and Cellular Oxidative Stress: Prognostic Implications in Cardiovascular Diseases. Acta Pharmacologica Sinica. 2018 Jul; 39(7):1120-1132. doi: 10.1038/aps.2018.25. Epub 2018 Jun 21.
  74. Cui C., Chang Y, Zhang X, Choi S, Tran H, Penmetsa KV, Viswanadha S, Fu L, Pan Z. Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma. Cancer Letters, 2018 Sep 28;432:169-179. doi: 10.1016/j.canlet.2018.06.006. Epub 2018 Jun 15. Corresponding author
  75. Fan Z, Chang Y, Cui C, Sun L, Huang Y, Wang D, Pan Z*, Zhang M*. Near-infrared Fluorescent Peptide Nanoparticles for Enhancing Esophageal Cancer Therapeutic Efficacy. Nat Commun. 2018 Jul 4; 9(1):2605. doi: 10.1038/s41467-018-04763-y. *Corresponding authors
  76. Tao K, Fan Z, Sun L, Makam P, Tian Z, Ruegsegger M, Shaham-Niv S, Hansford D, Aizen R, Pan Z, Galster S, Ma J, Yuan F, Si M, Qu S, Zhang M, Gazit E, Li J. Quantum confined peptide assemblies with tunable visible to near-infrared spectral range. Nat Commun. 2018 Aug 13; 9 (1):3217. doi: 10.1038/s41467-018-05568-9.


  • Zimering MB, Pan Z, Alder J, Thakker-varia S.
    Method for identifying diabetic patients at increased risk for pathological complications, USA, 7,972,798, issued on July 5, 2011
  • Ma J, Pan Z, Weisleder N.
    Compositions and Methods for Modulating Store-Operated Calcium Entry, USA, 8,071,533, issued on December 6, 2011

Book Chapters:

  • Zui Pan, Sangyong Choi, Yanhong Luo. 2018. Methods Molecular Biology, Vol. 1843; Book Title: The CRAC Channel (ISBN: 978-1-4939-8702-3); Chapter 4, Mn2+ Quenching Assay for Store-Operated Calcium Entry.


  1. Pan Z. Zinc Regulatory Functions in MG53-mediated Membrane Repair and in Orai1-mediated Cell Proliferation. FASEB Summer Conferences, Trace Elements in Biology and Medicine, June 3-8, 2018. Invited talk.
  2. Choi S, Pan Z. Zinc inhibits esophageal cancer cell proliferation through a calcium channel Orai1. FASEB Summer Conferences, Trace Elements in Biology and Medicine, June 3-8, 2018. Poster