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Tissue Biomechanics and Bioengineering Lab

The Tissue Biomechanics and Bioengineering Laboratory focuses on tissue biomechanics and regeneration. Our goal is to identify the essential mechanisms that determine optimal physiological functions, determine structural and mechanical abnormalities in diseases and injuries, and facilitate better biomimetic replacement development, surgical intervention and protective designs.

Our research interests include:

  • Cardiac tissue
  • Heart valve tissues
  • Maternal tissues
  • Tendons/Ligaments
  • Brain tissue
  • Other soft tissues/biomaterials

Personnel

  • Jun Liao, Ph.D., Lab Director
  • Xiaodan Shi, Ph.D., Postdoctoral Associate

Current Graduate Students

  • Katherine M. Copeland (Ph.D.)
  • Sara R. McMahan (Ph.D.)
  • Alan Taylor (M.S.)
  • Akhil M. Chaudhari (M.S.)
  • Brant M. Shipferling (M.S.)
  • Ojeen Korkes (M.S.)

Current Research Projects

Direction 1: Cardiac Biomechanics and Regeneration

Topic 1: Cardiac ECM Biomechanics in Heart Regeneration

Myocardial infarction (MI) affects more than 8 million Americans, causing massive heart cell death and heart function decrease. As a promising strategy, stem cell therapy delivers cells to damaged areas (scar tissues) to revitalize infracted heart. Unfortunately, the success rate for stem cells differentiating into cardiac muscle cells is extremely low, limiting the great potential of stem cells for cardiac repair and regeneration. In this project, we are investigating the underlying mechanisms that hinder the regenerative potential of stem cells in scar tissue of the damaged hearts. (Collaborators: Dr. Jianjun Guan/Ohio State University; Dr. Ryan Butler and Dr. Andrew Claude, Mississippi State University)

Topic 2: Cardiac Tissue Engineering via Acellular Myocardial Scaffolds

In this project, we assess whether the decellularized myocardial scaffold, along with coordinated multifaceted stimulations, promotes the differentiation of stem cells towards cardiomyocyte phenotype. The knowledge gained from the proposed research will help us better understand fundamental bioengineering in the development of a thick cardiac patch and benefit future exploration of whole-heart reconstruction using the scaffold template from a large animal heart. (Collaborators: Dr. Ge Zhang/University of Akron, Dr. Amy Curry/University of Memphis)

Topic 3: 3D Heart Muscle Fiber Disruption Reconstructed via Diffusion Tensor-MRI

Our study is the first attempt to characterize the disruption of the 3D myocardial fiber structure in an area of myocardial infarction and correlate this disruption with the structural and biomechanical changes of the infarcted myocardium. We have successfully created myocardial infarction in a pig model with a balloon catheterization technique, and developed a diffusion tensor magnetic resonance imaging (DT-MRI) protocol to image the infarcted heart explants and a 3D image reconstruction algorithm to reconstruct the muscle fiber architecture. We have demonstrated that the DT-MRI is able to visualize the disruption of the 3D myocai·dial fiber structure in the infarcted regions of heart explants. (Collaborator: Dr. Song Zhang/Mississippi State University)

Direction 2: Heart Valve Biomechanics and Bioengineering

We are currently investigating the ultrastructural mechanism, which minimizes creep and allows valve leaflets behaving as quasi-elastic "biological materials" in a manner that favors valvular function. Our other major contiibution in heart valve mechanics is to determine the intrinsic mechanisms of the structural degeneration of ECM due to various decellularization processes, as well as investigate the effects of decellularization on the fatigue resistance of valvular tissues. (Collaborators: Dr. Jianhua Gao/Brown University, Dr. Michael S. Sack/UT Austin)

Direction 3 - Injury Biomechanics and Human Body Simulation 

In this research direction, we are developing a high fidelity human body mesh with anatomic details of important organs/tissues using 3D reconstruction software and physically based constitutive models that capture the formation of tissue defects and their dependence on strain level and strain rate. The human body mesh has been integrated into finite element (FE) models that ai·e subsequently subjected to blast and crash impact events. The knowledge based on the integrated simulations will be applied to facilitate the development of safety countermeasures for combat vehiculai·systems and solider protective equipment. (Collaborators: Dr. Lakiesha Williams, Dr. Raj Prabhu, Dr. Mark F. Horstemeyer/MSU)

Publications

Journal Articles

  • Erin Brinkman, Sourav Patnaik, Benjamin Weed, Bryn Brazile, Robert Wills, Nicolas Olivier, Dodd Sledge, Avery J. Cooley, Jun Liao, Ann Rashmir. Cardiac findings in horses with heritable equine reginal dermal asthenia. Journal of the American Veterinary Medical Association. 250 (5), 538-547, 2017

  • Pawan KC, Mickey Shah, Jun Liao, Ge Zhang. Prevascularization of Decellularized Porcine Myocardial Slice for Cardiac Tissue Engineering. ACS applied materials & interfaces. 9 (3), 2196-2204, 2017

  • Christopher Deborde, Dan T. Simionescu, Cristopher Wright, Jun Liao, Leslie N. Sierad, Agneta Simionescu. Stabilized collagen and elastin-based scaffolds for mitral valve tissue engineering. Tissue Engineering Part A. 22(21-22):1241-1251, 2016

  • Kovach AK, Gambino JM, Nguyen V, Nelson Z, Szasz T, Liao J, Williams L, Bulla S, Prabhu R. Prospective Preliminary In Vitro Investigation of a Magnetic Iron Oxide Nanoparticle Conjugated with Ligand CD80 and VEGF Antibody As a Targeted Drug Delivery System for the Induction of Cell Death in Rodent Osteosarcoma Cells. Bioresearch Open Access. 5(1):299-307, 2016

  • Nayeon Lee, Mark F. Horstemeyer, Raj Prabhu, Jun Liao, Hongjoo Rhee, Youssef Hammi, Robert Moser, Lakiesha Williams, The geometric effects of a woodpeckers hyoid apparatus for stress wave mitigation. Bioinspiration & Biomimetics, 11(6) 066004, 2016

  • Mazin S Sirry, J Ryan Butler, Sourav S Patnaik, Bryn Brazile, Robbin Bertucci, Andrew Claude, Ron McLaughlin, Neil H Davies, Jun Liao, Thomas Franz. Characterization of the mechanical properties of infarcted myocardium in the rat under biaxial tension and uniaxial compression. Journal of the Mechanical Behavior of Biomedical Materials. 63: 252-264, 2016

  • Bo Wang, Sourav S. Patnaik, Bryn Brazile, J. Ryan Butler, Andrew Claude, Ge Zhang, Jianjun Guan, Yi Hong, and Jun Liao. Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs. Critical Review in Biomedical Engineering. 43(5-6): 455-471, 2016

  • William Zhang, Salma Ayoub, Jun Liao, Michael S. Sacks. A Meso-scale Layer-Specific Structural Constitutive Model of the Mitral Heart Valve Leaflets. Acta Biomaterialia. 32: 238–255, 2016

  • Rupak Dua, Kristin Comella,  J. Ryan Butler,  Glenda Castellanos,  Bryn Brazille,  Andrew Claude,  Arvind Agarwal,  Jun Liao,  Sharan Ramaswamy. Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles. PLOS ONE. 11 (2): e0149121, 2016

  • Amanda Pinheiro, Avery J. Cooley, Jun Liao, Raj Prabhu, and Steve Elder. Comparison of Natural Crosslinking Agents for the Stabilization of Xenogenic Cartilage. Journal of Orthopaedic Research. DOI:10.1002/jor.23121, 2016

  • MA Murphy, MF Horstemeyer, Steven R Gwaltney, Tonya Stone, Michelle LaPlaca, Jun Liao, Lakiesha Williams, R Prabhu. Nanomechanics of phospholipid bilayer failure under strip biaxial stretching using molecular dynamics. Modelling and Simulation in Materials Science and Engineering. 24 (5): 55008-55026, 2016

  • Erin Brinkman, Sourav Patnaik, Benjamin Weed, Bryn Brazile, Robert Wills, Nicholas Olivier, Dodd Sledge, Avery J. Cooley, Jun Liao, Ann Rashmir. Cardiac findings in horses with heritable equine regional dermal asthenia. Journal of the American Veterinary Medical Association. (In press, 2016) 2015

  • Bryn Brazile, Bo Wang, Guangjun Wang, Robbin Bertucci, Raj Prabhu, Sourav Patnaik, J. Ryan Butler, Andrew Claude, Erin Brinkman-Ferguson, Lakiesha N. Williams, and Jun Liao. On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants. 25:1-14, 2015

  • Wuwei Li, Guowu Ma, Bryn Brazile, Nan Li, Wei Dai, J Ryan Butler, Andrew A Claude, Jason A Wertheim, Jun Liao, Bo Wang. Investigating the Potential of Amnion-Based Scaffolds as a Barrier Membrane for Guided Bone Regeneration. Langmuir. 31 (31): 8642-8653, 2015

  • John Clemmer, Raj Prabhu, Joseph Chen, Erin Colebeck, Lauren B Priddy, Michael McCollum, Bryn Brazile, Wilbur Whittington, Jennifer L Wardlaw, Hongjoo Rhee, M F Horstemeyer, Lakiesha N. Williams, Jun Liao. Experimental Observation of High Starin Rate Responses of Porcine Brain, Liver, and Tendon. Journal of Mechanics in Medicine and Biology, 1650032, 2015

  • Benjamin Weed, Sourav Patnaik, Mary Rougeau-Browning, Bryn Brazile, Jun Liao, Raj Prabhu, Lakiesha N. Williams. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 8 (5): 2454-2466, 2015

  • Raj Prabhu, W. R. Whittington, Sourav S. Patnaik, Y. Mao, Mark. T. Begonia, Lakiesha. N. Williams, Jun Liao, Mark F. Horstemeyer. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials. Journal of Visualized Experiments. 25(1–2): 41–53, 2015

  • Ali Azadi, Sourav S Patnaik, Jacek B Jasinski, Sean L Francis, Zhenmin Lei, Jun Liao, Nicolette E Deveneau, Donald R Ostergard. Morphologic Evaluation of Post-implanted Monofilament Polypropylene Mesh Utilizing a Novel Technique with Scanning Electron Microscopy Quantification. Surgical technology international. 26: 169-173, 2015

  • Chung-Hao Lee, Will Zhang, Jun Liao, Christopher A. Carruthers, Jacob I. Sacks, Michael S. Sacks. On the Presence of Affine Fibril and Fiber Kinematics in the Mitral Valve Anterior Leaflet. Biophysical journal. 108 (8), 2074-2087, 2015

  • Leslie N. Sierad, Eliza L. Shaw, Alexander Bina, Bryn Brazile, Nicholas Rierson, Sourav S. Patnaik, Agneta Simionescu, Jun Liao, Ionela Movileanu, Marius Harpa, Dan T. Simionescu. Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System. Tissue Eng Part C Methods. (Epub ahead of print, PMID: 26467108), 2015

  • Feize Li, Jijun Yang, Jiali Liao, Shoujian Li, Jun Liao, Raj Prabhu, Lakiesha N Williams, Yuanyou Yang, Jun Tang, Ning Liu. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 276: 322-330, 2015 Sourav S Patnaik, Bryn Brazile, Vani Dandolu, Peter L Ryan, Jun Liao. Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome: A historical perspective. Gene. Jan 15;555(1):33-40, 2015 2014

  • Renee Pietsch, Benjamin B. Wheatley, Tammy L. Haut Donahue, Ryan Gilbrech, Raj Prabhu, Jun Liao, Lakiesha N William. The Anisotropic Compressive Properties of Porcine Muscle Tissue. Journal of Biomechanical Engineering. 136(11), 111003, 2014

  • Mark Begonia, Ruiyi Wu, Rajkumar Prabhu, Jun Liao, Wilburn R. Whittington, Andrew Claude, Bridget Willeford, Jennifer Wardlawe, Song Zhang, Lakiesha Williams. Quantitative Analysis of Rodent Brain Microstructure Following Mild Blunt and Blast Trauma. Journal of Biomechanics. 47:3704-3711, 2014

  • Yanyi Xu, Sourav Patnaik, Xiaolei Guo, Zhenqing Li, Wilson Lo, Ryan Butler, Andrew Claude, Zhenguo Liu, Ge Zhang, Jun Liao, Peter M Anderson, Jianjun Guan. Cardiac Differentiation of Cardiosphere-Derived Cells in Scaffolds Mimicking Morphology of the Cardiac Extracellular Matrix. Acta Biomaterialia. Aug;10(8):3449-62, 2014

  • Benjamin C. Weed, Toree L. Bova, Sourav S. Patnaik, Bryn Brazile, Cate Mochal-King, Bryan Rude, R. Prabhu, Lakiesha N. Williams, Jun Liao. 3D Printing–Assisted Rapid Prototyping and Optimization: Development of a Novel Small Intestinal Cannula for Equine Research. 3D Printing and Additive Manufacturing 1 (2), 104-106, 2014

  • Nayeon Lee, M. F. Horstemeyer, Hongjoo Rhee, Ben Nabors, Jun Liao, Lakiesha N. Williams. Hierarchical multiscale structure–property relationships of the red-bellied woodpecker (Melanerpes carolinus) beak. Journal of The Royal Society Interface 11 (96), 20140274, 2014

  • Alan D. Freed, Jun Liao, Daniel R. Einstein. A Membrane Model from Implicit Elasticity Theory: Application to Visceral Pleura. Biomechanics and Modeling in Mechanobiology. 13(4): 871-881, 2014

  • Kyle Johnson, Wes Trim, M. F. Horstemeyer, Nayeon Lee, Lakiesha Williams, Jun Liao, Hongjoo Rhee and R Prabhu. Geometric effects on stress wave propagation. Journal of Biomechanical Engineering. 136 (2), 021023, 2014

  • Valtresa Myles, Jun Liao, James N. Warnock. Cyclic Pressure and Angiotensin II Influence the Biomechanical Properties of Aortic Valves. Journal of Biomechanical Engineering. 136(1):011011, 2014 2013

  • Bo Wang, Guangjun Wang, Filip To, J. Ryan Butler, Andrew Claude, Ronald M. McLaughlin, Lakiesha N. Williams, Amy L. de Jongh Curry, and Jun Liao. “Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations.” Langmuir. 29(35): 11109-17, 2013

  • Jeremy Mercuri, Sourav S Patnaik, Grace Dion, Sanjitpal Gill, Jun Liao, and Dan T. Simionescu. “Regenerative Potential of Decellularized Porcine Nucleus Pulposus Hydrogel Scaffolds; Stem cell Differentiation, Matrix Remodeling and Biocompatibility Studies.” Tissue Engineering Part A. Apr;19(7-8):952-66, 2013

  • James P. Chow, Dan T. Simionescu, Harleigh Warner, Bo Wang, Sourav S. Patnaik, Jun Liao, Agneta Simionescu, “Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol.” Biomaterials, Jan;34(3):685-95, 2013 2012

  • Richard L. Summers, Weston Smith, Jun Liao Ryan Gilbrech, Benjamin C. Weed, Sourav Patnaik, and, “Influence Of Microgravity On Left Ventricular Sphericity: A Finite Element Model Of The Heart.” The American Institute of Aeronautics and Astronautics (AIAA) Journal, 2012

  • Bo Wang, Mary E. Tedder, Clara E. Perez, Guangjun Wang, Amy L. de Jongh Curry, Filip To, Steve H. Elder, Lakiesha N. Williams, Dan T. Simionescu, and Jun Liao. “Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix.” Journal of Materials Science – Materials in Medicine, Aug;23(8):1835-47, 2012

  • Benjamin C. Weed, Ali Borazjani, Sourav S. Patnaik, Rajkumar Prabhu, Mark F. Horstemeyer, Peter L. Ryan, Thomas Franz, Lakiesha N. Williams, Jun Liao. “Stress State and Strain Rate Dependence of the Human Placenta.” Annals of Biomedical Engineering, Oct;40(10):2255-65, 2012

  • Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao. “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.” Journal of Healthcare Engineering, 3(2): 179–202, 2012

  • Jun Liao, Erinn M. Joyce, W. David Merryman, Hugh L. Jones, Mina Tahai, Mark F. Horstemeyer, Lakiesha N. Williams, Richard A. Hopkins, and Michael S. Sacks. “The Intrinsic Fatigue Mechanism of Porcine Aortic Valve Extracellular Matrix.” Cardiovascular Engineering and Technology, 3(1):  62-72, 2012 2011

  • Jianjun Guan, Feng Wang, Zhenqing Li, Joseph Chen, Xiaolei Guo, Jun Liao, Nicanor I. Moldovan. “The Stimulation of the Cardiac Differentiation of Mesenchymal Stem Cells in Tissue Constructs that Mimic Myocardium Structure and Biomechanics.” Biomaterials, 32(24):5568-80, 2011   

  • R. Prabhu, M.F. Horstemeyer, M. Tucker, E.B. Marin, J.L. Bouvard, J. Sherburn, Jun Liao, Lakiesha Williams. “Coupled Experiment/Finite Element Analysis on the Mechanical Response of Porcine Brain under High Strain Rates” Journal of the Mechanical Behavior of Biomedical Materials, 4(7):1067-80, 2011

  • Ali Borazjani, Benjamin Weed, Sourav Patnaik, Jean Feugang, David Christiansen, Steven H. Elder, Peter L. Ryan, and Jun Liao. “A Comparative Biomechanical Analysis of Term Fetal Membranes in Human and Domestic Species.” American Journal of Obstetrics and Gynecology, 204(4):365.e25-36, 2011

  • K. Jane Grande-Allen and Jun Liao. “The Heterogeneous Biomechanics and Mechanobiology of the Mitral Valve: Implications for Tissue Engineering.” Current Cardiology Reports, 13(2):113-20, 2011

  • Mary E. Tedder, Agneta Simionescu, Joseph Chen, Jun Liao, Dan T. Simionescu. “Assembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering.” TISSU ENGINEERING Part A, 17(1-2):25-36, 2011

  • Wes Trim, Mark F. Horstemeyer, Hongjoo Rhee, Seong-Jin Park, Haitham El Kadiri, Lakiesha Williams, Jun Liao, and Joanna McKittrick. “Parametric study of the structure-property relations of bighorn sheep (Ovis canadensis) horn” Acta Biomaterialia, 7(3):1228-40, 2011

  • Emanuel Villa, Alayne Stewart White, Jun Liao, and Amy L. de Jongh Curry. "An Inexpensive Alternative Bath System for Electrophysiological Characterization of Isolated Cardiac Tissue." IEEE Eng Med Biol Soc: page: 8424-7, 2011 2010

  • John Clemmer, Jun Liao, Debbie Davis, Mark F. Horstemeyer, and Lakiesha Williams. “A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon.” JOURNAL OF BIOMECHANICS, 43(14):2785-91, 2010

  • Leslie N Sierad, Agneta Simionescu, Joseph Chen, Christopher Albers, Jordan Maivelett, Mary E Tedder, Jun Liao, Dan T. Simionescu. “Design and testing of a pulsatile conditioning system for dynamic endothelialization of polyphenol-stabilized tissue engineered heart valves.” Cardiovascular Engineering and Technology, Vol. 1 (2): 138–153, 2010

  • Bo Wang, Ali Borazjani, Mina Tahai, Amy L. de Jongh Curry, Dan T. Simionescu, Jianjun Guan, Filip To, Steve H. Elder, and Jun Liao. “Fabrication of Cardiac Patch with Decellularized Porcine Myocardial Scaffold and Bone Marrow Mononuclear Cells.” JOURNAL OF BIOMEDICAL MATERIALS RESEARCH Part A, 15;94(4):1100-10, 2010

  • Mark T. Begonia, Raj Prabhu, Jun Liao, Mark F. Horstemeyer Lakiesha N. Williams. “The influence of strain rate dependency on the structure-property relations of porcine brain.” ANNALS OF BIOMEDICAL ENGINEERING, 38(10):3043-57, 2010

  • Song Zhang, J. Allen Crow, Xiaoyong Yang, Joseph Chen, Ali Borazjani, Katie B Mullins, Wei Chen, Robert C. Cooper, Ronald M. McLaughlin, Jun Liao. “The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium.” ANNALS OF BIOMEDICAL ENGINEERING, 38(10):3084-95, 2010

  • James Warnock, Carol Pregonero Gamez, Scott Metzler, Joseph Chen, Steven Elder, and Jun Liao. Vasoactive Agents Alter the biomechanical Properties of Aortic Heart Valve Learlets in a Time-dependent Manner, JOURNAL OF HEART VALVE DISEASE, 19(1): 86-96, 2010 2009 

  • Wei Chen, Zhicheng Yan, Song Zhang, John A. Crow, Ronald M. McLaughlin, Katie B. Mullins, Robert Cooper, David Ebert, Zi’ang Ding, and Jun Liao,. Modeling and Illustration of Muscle from Diffusion Tensor Images. IEEE Transactions on Visualization and Computer Graphics, 15(6):1425-32, 2009

  • Jun Liao, Lauren B. Priddy, Bo Wang, Joseph Chen, and Ivan Vesely. “Ultrastructure of Porcine Mitral Valve Chordae Tendineae.” JOURNAL OF HEART  VALVE DISEASE, 18(3), 292-299, 2009

  • Erin M. Joyce, Jun Liao, John E. Mayer, Michael S. Sacks. Effects of Transvalvular Pressure on Pulmonary Valve Microstructure, ANNALS OF THORACIC SURGERY. 87(4):1240-9, 2009

  • Corin Williams, Jun Liao, Erinn M. Joyce, Bo Wang, Jennie B. Leach, Michael S. Sacks, and Joyce Y. Wong. “Structural and Mechanical Properties of Decellularized Rabbit Carotid Arteries.” ACTA BIOMATERIALIA, 5(4):993-1005, 2009

  • Mary E. Tedder, Jun Liao, Benjamin Weed, Christopher Stabler, Henry Zhang, Agneta Siminonescu, and Dan T. Siminonescu. “Stabilized acellular pericardium: novel collagen scaffold for heart valve tissue engineering.” TISSU ENGINEERING Part A, 15(6):1257-68, 2009 2008

  • Jun Liao, Erin M. Joyce, Michael S. Sacks. Effects of decellularization on mechanical and structural properties of the porcine aortic valve leaflets, BIOMATERIALS. Mar; 29(8):1065-74, 2008.

  • John A. Stella, Jun Liao, Yi Hong, W. David Merryman, William R. Wagner, and Michael S. Sacks. Tissue-Cellular Deformation Coupling in Cell-Micro integrated Electrometric Scaffolds. BIOMATERIALS. 29(22):3228-36, 2008

  • Pietro Bajona, Kenton J. Zehr, Jun Liao, Giovanni Speziali. “Tension Measurement of Artificial Chordae Tendineae Implanted Between the Anterior Mitral Valve Leaflet and the Left Ventricular Apex: An In Vitro Study.” INNOVATIONS: Technology and Techniques in Cardiothoracic and Vascular Surgery. Vol. 3 (1) 33-37, 2008 2007

  • Jun Liao, Lin Yang, Jonathan S. Grashow, Michael S. Sacks. "The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leaflet," JOURNAL OF BIOMECHANICAL ENGINEERING, Feb; 129 (1):78-87, 2007

  • Jun Liao, Ivan Vesely. "Skewness Angle of Interfibrillar Proteoglycans Increases with Applied Load on Chordae Tendineae." JOURNAL OF BIOMECHANICS, 40(2):390-8, 2007

  • John A. Stella, Jun Liao, and Michael S. Sacks. "Time dependent biaxial mechanical behavior of the aortic heart valve leaflet." JOURNAL OF BIOMECHANICS, 40(14):3169-77, 2007 

  • W. David Merryman, Jun Liao, Aeron Parekh, Joseph E. Candiello, Hai Lin, Michael S. Sacks. "The Heart Valve Interstitial Cell Cytoskeleton: Role in Cell Stiffness, Contraction and Tissue Remodeling," TISSUE ENGINEERING 13 (9): 2281-2289 SEP 2007

  • H.Y. Shadow Huang, Jun Liao, and Michael S. Sacks. "In-situ deformation of the aortic heart valve interstitial cell nucleus under diastolic loading." JOURNAL OF BIOMECHANICAL ENGINEERING 129(6):880, 2007 2003-2006

  • Jonathan S. Grashow, Michael S. Sacks, Jun Liao, Ajit P. Yoganathan. "Planar biaxial creep and stress relaxation of the mitral valve anterior leaflets." ANNALS OF BIOMEDICAL ENGINEERING Oct; 34 (10): 1509-18, 2006

  • W. David Merryman, George C. Engelmayr, Jun Liao, and Michael S. Sacks. "Defining Biomechanical Endpoints for Tissue Engineered Heart Valve Leaflets from Native Leaflet Properties." PROGRESS IN PEDIATRIC CARDIOLOGY Vol. 21, pp. 153-60, 2006

  • Jun Liao, Lin Yang, Jonathan S. Grashow, Michael S. Sacks. "Molecular orientation of collagen in intact planar connective tissue under biaxial stretch." ACTA BIOMATERIALIA, Vol. 1, p. 45-54, 2005

  • Jun Liao, Ivan Vesely. "The relationship between collagen fibrils, glycosaminoglycans and stress relaxation in mitral valve chordae tendineae." ANNALS OF BIOMEDICAL ENGINEERING Jul;32(7):977-83, 2004 67.  Jun Liao, Ivan Vesely. "A structural basis for the size-related mechanical properties of mitral valve chordae tendineae." JOURNAL OF BIOMECHANICS 36/8: p1125-1133, 2003

Book Chapters

  • Bryn Brazile, Sallie Lin, Katherine M. Copeland, J. Ryan Butler, Jianjun Guan, and Jun Liao. Ultrastructure and Biomechanical Properties of the Skeletal Muscle ECM: Implications in Tissue Regeneration. Skeletal Muscle Regeneration. Editor: Justin Brown, Elsevier (In press, 2016)

  • Sourav S. Patnaik, Ali Borazjani, Bryn Brazile, Benjamin Weed, David Christiansen, Peter L. Ryan, C.H. van der Vaart, Margot Damaser, Jun Liao. Chapter 6: "Pelvic Floor Biomechanics from Animal Models" in Biomechanics of the Female Pelvic Floor, Editors: Lennox Hoyte and Margot Damaser, Elsevier, Pages 131–148, 2016

  • Bo Wang, Lakiesha Williams, Amy L. de Jongh Curry, Jun Liao. Chapter Title: “Preparation of Acellular Myocardial Scaffolds with Well-preserved Cardiomyocyte Lacunae, and Method for Applying Mechanical and Electrical Simulation to Tissue Construct.” Book Title: Cardiac Tissue Engineering Methods and Protocols. Editors: Milica Radisic and Lauren Black; Springer Science. 1181:189-202, 2014

  • Sourav S. Patnaik, Bo Wang, Benjamin Weed, Jason A. Wertheim, Jun Liao, Chapter 3: “Decellularized Scaffolds: Concepts, Methodologies, and Applications in Cardiac Tissue Engineering and Whole-Organ Regeneration,” Tissue Regeneration: Where Nanostructure Meets Biology, Editor: Qing Liu; World Scientific Company, page 77-124, 2013

  • Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao. Chapter Title: “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering. Book Title: “Advances in Engineering for Surgery – from information-guided surgery to cell-based medicine.” Editor: Ming Chyu; Multi-Science Publishing Company; Page 25-248, 2013

  • John A. Stella, Jun Liao, Yi Hong, W. David Merryman, William R. Wagner, and Michael S. Sacks. "Tissue-to-cellular deformation coupling in cell microintegrated elastomeric scaffolds." IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, IUTAM Bookseries: Volume 16 (Part 2) 81-89, Springer Netherlands, 2010.

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