The University of Texas at Arlington

Daniel W. Armstrong

Daniel  Armstrong

Professor
Robert A. Welch Chair in Chemistry

Office: 303 CRB, Email: sec4dwa@uta.edu, Phone: 817-272-0632, FAX: 817-272-0619

Research ProfileCourses

Molecular Recognition, esp. chiral & isomeric

Separation Science

Ionic Liquids: synthesis, characterization & use

Ordered Media, including micelles & macrocyclic compounds

Enantiomeric Separations

Mass Spectrometry

Chromatography

Drug, Environmental & Food Analysis

"Separation and Sensitive Detrmination of Sphigolipids at Low Femtomole Level by Using HPLC-PIESI-MS/MS", Xu, C., Costa Pinto, E. and Armstrong, D.W., Analyst, 139, 4169-4175 (2014).

"Computerized optimization of flows and temperature gradient in flow modulated comprehensive two-dimensional gas chromatography", M‡jeka, P., Krupc’k, J., Gorovenkoa, R., Sp‡nika, I.,Sandra, P. and Armstrong, D.W., J. Chrom. A., 1349 135-138 (2014).

"Mechanism and Sensitivity of Anion Detection Using Rationally Designed Unsymmetrical Dications in Paired Ion Electrospray Ionization Mass Spectrometry", Xu, C., Guo, H., Breitbach, Z.S. and Armstrong, D.W., Anal. Chem. 86, 2665-2672 (2014).

"Rapid Analysis of Ethanol and Water in Commercial Products Using Ionic Liquid Capillary Gas Chromatography with Thermal Conductivity Detection and/or Brarier Discharge Ionization Detection", Weatherly, C., Woods, R.M. and Armstrong, D.W., J. Agricultural and Food Chem., 62, 1832-1838 (2014).

"Isopropyl derivative of cyclofructan 6 as chiral selector in liquid chromatography and capillary electrophoresis", Maiera, V., Kal’kov‡b, K., Pribylkaa, A., Vozkab, J., Smuts, J., Svidrnocha, M., Sevc’k, J., Armstrong, D.W. and Tesarov‡, E., J. Chrom. B., 1338, 197-200 (2014).

"Water Determination in Active Pharmaceutical Ingredients Using Ionic Liquid Headspace Gas Chromatography and Two Different Detection Protocols", Frink, L.A.; Weatherly, C.A. and Armstrong, D.W., J. Pharma. Biomed. Anal., 94, 111-117 (2014).

"On the Use of Quadrupole Mass Sprectrometric Detection for Flow Modulated Comprehensive Two-Dimensional Gas Chromatography", Gorovenko, R., Krupcik, J., Spanik, I., Bockova, I., Sandra, P. and Armstrong, D.W., J. Chrom. A. 1330 51-60 (2014).

"Enantiomeric Separations of Chiral Sulfonic and Phosphoric Acids with Barium-Doped CyclofructanSelectors via an Ion Interaction Mechanism", Smuts, J.P., Hao, X., Han, Z., Parpia, C., Krische, M.J. and Armstrong, D.W., Anal. Chem. 86, 1282-1290 (2014).

"Enantiomeric Impurities in Chiral Catalysts, Auxilairies, and Synthons Used in Enantioselective Synethese. Part 4", Qiu, H., Padivitage. N.L.T., Frink. L.A. and Armstrong, D.W., Tetrahedron: Asymmetry 24, 1134-1141 (2013).

"Enantioseparation of Flinderoles and Borreverines by HPLC on Chirobiotic V and V2 Stationary Phases and by CE Using Cyclodextrin Selectors", Smuts, J.P., Na, Y., Vallakati, R., Pribylka, A., May, J.M. and Armstrong, D.W., Anal. Bioanal. Chem. 405 9169-9177 (2013).

"On the Use of Ionic Liquid Capillary Columns for Analysis of Aromatic Hydrocarbons in Low-boiling Petrochemical Products by One-dimensional and Comprehensive Two-dimensional Gas Chromatography", Krupc’k, J, Gorovenko, I, Sp‡nik, Bockov‡b, I, Sandra, P, and Armstrong, DW, J. Chrom. A. 1301 225-236 (2013).

"1,3-Dimethylamylamine (DMAA) in Supplements and Geranium Products: Natural or Synthetic?", Zhang, Y., Woods, R. M., Breitbach, Z.S. and Armstrong, D.W., Drug Test. Analysis, 4, 986-990 (2012).

"Degradation Study of Carnosic Acid, Carnosol, Rasmarinic Acid, and Rosemary (Rosmarinus officinalis L.) Assessed Using HPLC", Zhang, Y., Smuts, J., Dodbiba, E., Rangarajan, R., Lang, J.C. and Armstrong, D.W., J. Agri. Food Chem. 60 9305-9314 (2012).

"CE-ESI-MS Separation of Divalent Organic and Inorganic Anions Using a Tricationic Complexing Reagent", Gerardi, A.R., Lin, X., Breitbach, Z.S., Armstrong, D.W. and Colyer, C.L.; Electrophoresis, 33 7334-740 (2012).

"Sensitive Analysis of Metal Cations in Positive Ion Mode Electrospray Ionization Mass Spectrometry using Commercial Chelating Agents and Cationic Ion-pairing Reagents", Dodbiba, E., Xu, C., Wanigasekara, E. and Armstrong, D.W.; Rapid Commun. Mass Spectrom, 26, 1005-1013 (2012).

"Structure and Dynamics of the 1-Hydroxyethyl-4-amino-1,2,4-triazolium Nitrate High-Energy Ionic Liquid System", Carlson, P.J., Bose, S., Armstrong, D.W., Hawkins, T., Gordon, M.S., and Petrick, J.W., J Phys Chem B, 116 503-512 (2012).

"Chiral Ionic Liquids: A Compendium of Syntheses and Applications (2005-2012)", Payagala, T. and Armstrong, D.W., Chirality 24, 17-53 (2012).

"A Liquid Drop RC Filter Apparatus forDdetection", Nanayakkara,Y. and Armstrong, D.W., Anal. Bioanal. Chem. 401, 2669-2678 (2011).

"Development and Evaluation of New Zwitterionic Hydrophilic Interaction Liquid Chromatography Stationary Phases Based on 3-P,P-diphenylphosphoniumpropylsulfonate", Qiu, H., Wanigasekara, E., Zhang, Y., Tran, T. and Armstrong, D.W., J. Chrom. A. 1218, 8075-8082 (2011).

"Use of Ion Pairing Reagents for Sensitive Detection and Separation of Phospholipids in the Positive Ion Mode LC-ESI-MS", Dodbiba, E., Xu, C., Payagala, T., Wanigasekara, E., Moon, M.H. and Armstrong, D.W., Analyst, 136 1586-1593 (2011).

"Enhanced Comprehensive Two-Dimensional Gas Chromatographic Resolution of Polychlorinated Biphenyls on a Non-Polar Polysiloxane and an Ionic Liquid Column Series", Zapadlo, M., Krupcik, J., Kovalczuk, T., Majek, P., Spanik, I., Armstrong, D.W. and Sandra, P., J. Chrom. A., 1218 746-751 (2011).

"A Rapid Capillary Electrophoresis Method for the Detection of Microbial Contamination: An Alternative Approach for Sterility Testing", Bao, Y., Lantz, A.W. and Armstrong, D.W., Pharmacopeial Forum, Vol. 36(6) 1798-1805 (Nov-Dec 2010)

"High-performance Liquid Chromatographic Enantioseparation of Monoterpene-based 2-amino carboxylic acids on macrocyclic glycopeptides-based phases", Sipos, L., Ilisz, I., Pataj, Z., Szakonyi, Z., Fulop, F., Armstrong, D.W. and Peter, A., J. Chromatogr. A., 1217 6956-6963 (2010).

"A Tunable Ionic Liquid Based RC Filter Using Electrowetting: A New Concept", Nanayakkara, Y.S., Moon, H. and Armstrong, D.W., Applied Materials & Interfaces, Vol. 2 No. 7 1785-1787 (2010).

"Effective Enantiomeric Separations of Racemic Primary Amines by the Isopropyl Carbamate-cyclofructan6 Chiral Stationary Phase", Sun, P. and Armstrong, D.W., J. Chromatogr. A., 1217 4904-4918 (2010).

"Increasing Selectivity in Comprehensive Three-dimensional Gas Chromatography Via an Ionic Liquid Stationary Phase Column in One Dimension", Siegler, W. C., Crank, J.A., Armstrong, D.W. and Synovec, R.E., J. Chrom. A, 1217 3144-3149 (2010).

"The Effect of AC Frequency on the Electrowetting Behavior of Ionic Liquids", Nanayakkara, Y.S., Perera, S., Bindiganavale, S., Wanigasekara, E., Moon, H. and Armstrong, D.W., Anal. Chem. 82 3146-3154 (2010).

"Ionic Liquids in Analytical Chemistry", Sun, P. and Armstrong, D.W., Analytica Chimica Acta 661 1-16 (2010).

"The Advent and Potential Impact of Ionic Liquid Stationary Phases in GC and GCxGC", Armstrong, D.W., Payagala, T. and Sidisky, L.M., LCGC North America 27 596-605 (2009)

"Towards a Second Generation of Ionic Liquid Matrices (ILMs) for MALDI-MS of Peptides, Proteins, and Carbohydrates", Crank, J. A. and Armstrong, D.W., J. Am. Soc. Mass. Spectrom., 20 1790-1800 (2009).

"A Fundamental Study on Electrowetting by Traditional and Multifunctional Ionic Liquids: Possible Use in electrowetting Components in Dielectric-Based Microfluidic Applications", Nanayakkara, Y.S, Moon, S, Payagala, T, Wijeratne, A.B, Crank, J.A, Sharma, P.S, Armstrong, D.W., Anal. Chem. 80 7690-7698 (2008).

"Characterization of Phosphonium Ionic Liquids Through a Liner Solvation Energy Relationship and Their Use as GLC Stationary Phases". Breitbach, Z.S. and Armstrong, D.W., Anal. & Bioanal. Chem. 390 1605-1617 (2008).

B.Sc. Washington and Lee University (1972)

M.S. in Oceanography, Texas A&M University (1974)

Ph.D. in Bio-Organic Chemistry, Texas A&M University (1977)

Daniel Armstrong has nearly 600 publications, including 29 book chapters, one book (“Use of Ordered Media in Chemical Separations”) and 26 patents. He has been named by the Scientific Citation Index as one of the world’s most highly cited scientists, and he has given over 500 invited seminars and colloquia worldwide.

Daniel Armstrong is considered the “Father” of micelle and cyclodextrin-based separations, he elucidated the first chiral recognition mechanism by cyclodextrins, he was the first to develop macrocyclic antibiotics as chiral selectors, and he is one of the world’s leading authorities on the theory, mechanism, and use of enantioselective molecular interactions. Over 30 different LC and GC columns that were originally developed in his laboratories have been commercialized and/or copied worldwide. His work and columns were in part responsible for the chromatography and electrophoresis-lead revolution in chiral separations over the last two and one half decades.

Currently, the columns, chiral selectors and techniques he developed dominate the world of analytical enantiomeric separations. Recently, he developed the first high efficiency CE separation approach for microorganisms (i.e., bacterial, viruses, fungi, etc.). This will extend the realm of separation science into the mainstream of biology and colloid science.

He has developed the most effective way to characterize the solvent properties of room temperature ionic liquids (RTILs). This has proven to be an essential and effective way to explain the effect of RTILs on organic reactions, and in various analytical methodologies. Surfactant aggregation to form normal micelles in RTILs was demonstrated. The first MALDI-MS matrices and high stability GC stationary phases based on RTILs were developed in his laboratories and were recently commercialized by Supelco/Sigma/Aldrich. The new enhanced mass spectrometry technique of PIESI (Paired Ion Electrospray Ionization) was developed in his laboratory and is one of the most sensitive methods for ultra-trace anion analyses and speciation.

Awards

1975 Elected to the Honorary Chemical Society: Phi Lambda Upsilon

1985 Outstanding Teacher Award, TTU.

1988 Faculty Excellence Award, UMR

1991 Great Britain’s Martin Medal for Outstanding Contributions to Chromatography

1993 ACS 49th Mid-west Regional Award

1993 Presidential Award for Research and Creativity

1995 R&D 100 Award

1996 A. A. Benedette-Pichler Award

1998 ACS Helen M. Free Award for Public Outreach

1999 American Chemical Society Award in Chromatography

1999 Hope College Distinguished Scholar

2001 Weber Medal for Contributions to Pharmaceutical Science

2002 ACS Kenneth A. Spenser Award for Meritorious Achievement in Food & Agriculture Science

2003 Chirality Medal, Shizuoka, Japan

2004 Vladimir J. Zuffa Medal for Pharmaceutical Chemistry

2005 Dal Nogare Award for Separation Science

2007 Medal of the Slovak Medical Society

2009 Admitted as a Fellow of The Royal Society of Chemistry

2012 UTA Distinguished Record of Research or Creative Activity

2013 Named American Chemical Society Fellow

Named to the Analytical Scientist’s 2013 Power List top 20

2014 ACS Award for Separation Science & Technology

2014 M.J.E. Golay Award, Riva del Garde, Italy

2014 UT Arlington Distinguished Scholars Award

2014 Inducted to the UTA Academy of Distinguished Scholars

(List does not include named lectureships, visiting professorships, lecture or poster awards, etc.)

Professorial (Distinguished ) Chairs:

1989 Curator’s Professorship (U. Missouri-Rolla)

2000 Caldwell Professorship (Iowa State University)

2006 Robert A. Welch Professorship (University of Texas at Arlington)

Editorial Recognitions

Separations Associate Editor for Analytical Chemistry.

Former Editor of Chirality.

Section Editor for Amino Acids.

Member of the Editorial Board of

Journal of Pharmaceutical & Biomedical Analysis

Amino Acids Journal

The Journal of Chromatography

The Journal of Liquid Chromatography

The Journal of Planar Chromatography

Journal of Inclusion

Phenomena, Separation Science and Technology

Chromatographia

Member of the Instrumentation Board for Analytical Chemistry, 1990.

Member of the Scientific Advisory Board for Analytical Chemistry, 1996-98.

1999 Editorial Advisory Board of Chromatographia,

2001 Editorial Advisory Board for Electrophoresis, Chromatographia

2008 Editorial Board for Scientia Chromatographia

Department of Chemistry and Biochemistry

The University of Texas at Arlington · Arlington, Texas 76019-0065 USA

Phone: 817-272-3171 | Fax: 817-272-3808

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