The University of Texas at Arlington

Daniel W. Armstrong

Daniel  Armstrong

Professor
Robert A. Welch Chair in Chemistry

Office: 303 CRB, Email: sec4dwa@uta.edu, Phone: 817-272-0632, FAX: 817-272-3808

Research ProfileCourses

Representative Publications:

“Consideration on HILIC and polar organic solvent-based separations: Use of
cyclodextrin and macrocyclic glycopetide stationary phases”, Wang, C., Jiang, C.,
Armstrong, D.W., J. Sep. Sci. 31 1980-1990 (2008).

“Comprehensive two-dimensional gas chromatography using a high-temperature phosphonium
ionic liquid column”, Seeley, J.V., Seeley, S.K., Libby, E.K., Breitbach, Z.S.,
Armstrong, D.W., Anal. Bioanal. Chem. 390:323-332 (2008).

“Rapid baseline separation of enantiomers and a mesoform of all-trans-astaxanthin,
13-cis-astaxanthin, adonirubin, and adoninanthin in standards and commercial
supplements”, Wang, C., Armstrong, D.W., Chang, C., J. Chromatogr. A., 1194 172-177
(2008).

“Influence of Chiral Ionic Liquids on the Excited-State Properties of Naproxen
Analogs”, Adhikary, R., Bose, S., Mukherjee, P., Thite, A., Kraus, G.A., Wijeratne,
A.B., Sharma, P.S., Armstrong, D.W., Petrich, J.W., J. Phys. Chem. B 112
7555-7559 (2008).

“Evaluating the Use of Tricationic Reagents for the Detection of Doubly Charged Anions
in the Positive Mode by ESI-MS” Soukup-Hein, R.J., Remsburg, J.W., Breitbach,
Z.S., Sharma, P.S., Payagala, T., Wanigasekara, E., Huang, J., Armstrong, D.W.,
Anal. Chem. 80 2612-2616 (2008).

“Unsymmetrical Dicationic Ionic Liquids: Manipulation of Physicochemical Properties
Using Specific Structural Architectures”, Payagala, T., Huang, J., Breitbach, Z.S.,
Sharma, P.S., Armstrong, D.W.  Chem. Mater. 19 5848-5850 (2007).

“Enantiomeric Separations of Ruthenium(II) Polypyridyl Complexes Using High-Performance
Liquid Chromatography (HPLC) with Cyclodextrin Chiral Stationary Phases (CSPs)”, Sun,
P., Krishnan, A., Yadav, A., Singh, S., MacDonnell, F.M., Armstrong, D.W.  Inorg.
Chem. 46 10312-10320 (2007).

“Enantioseparation of Extended Metal Atom Chain Complexes: Unique Compounds of
Extraordinarily High Specific Rotation”, Warnke, M.M., Cotton, F.A., Armstrong,
D.W.  Chirality 19: 179-183 (2007).

“Single-Cell Detection: Test of Microbial Contamination Using Capillary
Electrophoresis”, Lantz, A.W., Bao, Y., Armstrong, D.W., Anal. Chem. 79 1720-1724
(2007).

“Ionic Liquids in Separations”, Han, X., Armstrong, D.W., Acc. Chem. Res. 40
1079-1086 (2007).

“A General, Positive Ion Mode ESI-MS Approach for the Analysis of Singly Charged
Inorganic and Organic Anions Using a Dicationic Reagent”, Soukup-Hein, R.J., Remsburg,
J.W., Dasgupta, P.K., Armstrong, D.W., Anal. Chem. 79 7346-7352 (2007).

“Ionic liquid-alkane association in dilute solutions”, Berthod, A., Kozak, J.J.,
Anderson, J.L. Ding, J., Armstrong, D.W., Theor. Chem. Acc. 117 127-135 (2007).

“Highly Efficient Asymmetric Direct Stoichiometric Aldol Reactions on/in Water”,
Huang, J., Zhang, X., Armstrong, D.W. Angew. Chem. Int. Ed. 46 9073-9077 (2007).

“Theory and Use of the Pseudophase Model in Gas-Liquid Chromatographic Enantiomeric
Separations”, Pino, V., Lantz, A. W., Anderson, J. L., Berthod, A., and Armstrong, D.W
 Analytical. Chemistry 78, 113-119  (2006).

“Immobilized Ionic Liquids as High-Selectivity/High-Temperature/High-Stability Gas
Chromatography Stationary Phases”,  Anderson, J. and Armstrong, D.W. 
Analytical Chemistry  77(19), 6453-6462, (2005).

“Using Geminal Dicationic Ionic Liquids as Solvents for High Temperature Organic
Reactions”,  Han, X. and Armstrong, D.W.  Organic Letters  7(19),
4205-4208, (2005).

“Chiral Ionic Liquids: Synthesis and Applications”, Ding, J. and Armstrong,
D.W.  Chirality, 17(5), 281-292  (2005).

“Uptake and Enantioselective Elimination of Chlordane Compounds by Common Carp
(Cyprinus carpio, L.)”, Berthod, A, Seemamahannop, R., Maples, M., Shubhi, K., and
Armstrong, D.W.   Chemosphere, 59(4), 493-500  (2005).

“Pharmacokinetics and Pharmacodynamics of Theanine Enantiomers in Rats”, 
Desai, M.J., Gill, M.S., Hsu, W.H., and Armstrong, D.W.  Chirality, 17(3),
154-162  (2005).

”Use of Chiral Ionic Liquids as Solvents for the Enantioselective Photoisomerization of
Dibenzobicyclo[2.2.2] Octatrienes”,  Ding, J., Desikan, V., Han, X., Xiao, T.L.,
Ding, R., Jenks, W.S., and Armstrong, D.W.  Org. Lett.  7(2), 335-337 
(2005).

“Structure and Properties of High Stability Geminal Dicationic Ionic
Liquids”,  Anderson, J.L., Ding, R., Ellern, A., and Armstrong, D.W.  J. Am.
Chem. Soc. 127(2),  593-604  (2005).

“Chiral Ionic Liquids as Stationary Phases in Gas Chromatography”, Ding. J.,
Welton, T. and Armstrong, D.W.  Anal. Chem.  76(22),  6819-6822 (2004).

“Selective Separations of Peptides with Sequence Deletions, Single Amino Acid
Polymorphisms, and/or Epimeric Centers Using Macrocyclic Glycopeptide Liquid Chromatography
Stationary Phases”,  Zhang, B., Soukup, R., and Armstrong, D.W.  J. Chroma.
A  1053(1-2),  89-99 (2004).

“Dynamic Solvation in Room Temperature Ionic Liquids”, Chowdhury, P.K., Halder,
M., Sanders, L., Calhoun, T., Anderson, J.L., Armstrong, D.W., Song, X., and Petrich,
J.W.,  J. Phys. Chem. B  108,  10245-10255 (2004).

“Surfactant Solvation Effects and Micelle Formation in Ionic
Liquids”,    Anderson, J.L.,  Pino, V., Hagberg, E.C., 
Sheares, V.V., and Armstrong, D.W.  Chem. Comm. (Cambridge, United Kingdom) 
(19),  2444-2445  (2003).

“Pore Exclusion Chromatography-Inductively Coupled Plasma-Mass Spectrometry for
Monitoring Elements in Bacteria: A Study on Microbial Removal of Uranium from Aqueous
Solution”,  Zhang, B., Li, F., Houk, R. S., and Armstrong, D.W.  Anal.
Chem.  75(24),  6901-6905  (2003).

“Determination of the Interconversion Energy Barrier of Enantiomers by Separation
Methods”,  Krupcik, J., Oswald, P., Majek, P., Sandra, P., and Armstrong, D.
W.  J. of Chromatogr. A. 1000(1-2),  779-800 (2003).

“Ionic Matrices for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight
Detection of DNA Oligomers”,  Carda-Broch, S., Berthod, A., and Armstrong, D.
W.  Rap. Comm. in Mass Spec.  17(6), 553-560 (2003).

“Assignment of Absolute Configuration of a Chiral Phenyl-Substituted
Dihydrofuroangelicin”,  Pescitelli, G., Berova, N., Xiao, T. L., Rozhkov, R. V.,
Larock, R. C., and Armstrong, D. W.  Org. & Biomol. Chem.  1(1), 186-190
(2003).

"Characterizing Ionic Liquids On the Basis of Multiple Solvation Interactions", Anderson,
J.L., Ding, J., Welton, T., and Armstrong, D.W.  J. Amer. Chem. Soc.
124(47),  14247-14254 (2002).

"Super/Subcritical Fluid Chromatography Chiral Separations with Macrocyclic Glycopeptide
Stationary Phases", Liu, Y., Berthod, A., Mitchell, C., Xiao, T.L., Zhang, B., and
Armstrong, D.W.  J. of Chromatogr. A. 978(1-2) 185-204 (2002).

"A Potent Enantioselective Auxin: Indole-3-Succinic Acid", Armstrong, D.W., Liu, Y-S., He,
L., Ekborg-Ott, K., Barnes, C. L., and Hammer, C.F.  J. Agri. and Food Chem. 
50(3), 473-476 (2002).

"Determination of Cell Viability in Single or Mixed Samples Using Capillary Electrophoresis
Laser-induced Fluorescence Microfluidic Systems", Armstrong, D.W and He, L. Anal. Chem. 73,
4551-4557 (2001).

"Ionic Liquids as Matrices for Matrix-Assisted Laser Desorption Ionization Mass
Spectrometry", Armstrong, D.W., Zhang, L.-K., He, L., and Gross, M.  Anal. Chem. 73,
3679-3686 (2001).

"Separating Microbes in the Manner of Molecules: I. Capillary Electrokinetic Approaches",
D.W. Armstrong, G. Schulte, J.M. Schneiderheinze and D.J. Westenberg, Anal. Chem., 71, 5465-5469
(1999).

“Examination of Ionic Liquids and Their Interactions with Molecules, When Used as
Stationary Phases in Gas Chromatography, Daniel W. Armstrong, Lingfeng He, and Yan-Song Liu,
Anal. Chem., 71, 3873-3876 (1999).


B.Sc. Washington and Lee University (1972)

M.S. in Oceanography, Texas A&M University (1974)

Ph.D. in Bio-Organic Chemistry, Texas A&M University (1977)

Caldwell Distinguished Professor, Iowa State University (2000-2005)

Dan Armstrong has over 450 publications, including twenty-two book chapters, one book ("Use of Ordered Media in Chemical Separations") and eleven patents. He has been named by the Scientific Citation Index as one of the world’s most highly cited scientists, and he has given over 420 invited seminars and colloquia worldwide.

Daniel Armstrong is considered the "Father" of micelle and cyclodextrin-based separations, he elucidated the first chiral recognition mechanism by cyclodextrins, he was the first to develop macrocyclic antibiotics as chiral selectors, and he is one of the world's leading authorities on the theory, mechanism, and use of enantioselective molecular interactions.  Over 30 different LC and GC columns that were originally developed in his laboratories have been commercialized and/or copied worldwide. His work and columns were in part responsible for the chromatography and electrophoresis-lead revolution in chiral separations over the last two and one half decades.

Currently, the columns, chiral selectors and techniques he developed dominate the world of analytical enantiomeric separations. Recently, he developed the first high efficiency CE separation approach for microorganisms (i.e., bacterial, viruses, fungi, etc.). This will extend the realm of separation science into the mainstream of biology and colloid science.

He also has developed the most effective way to characterize the solvent properties of room temperature ionic liquids (RTILs). This has proven to be an essential and effective way to explain the effect of RTILs on organic reactions, and in various analytical methodologies.
Surfactant aggregation to form normal micelles in RTILs was demonstrated. The first MALDI-MS matrices and high stability GC stationary phases were also developed. Most recently, chiral RTILs have been shown to produce enantiomeric excesses from racemates and prochiral molecules via solvation effects. These solvation effects also change the luminescence behavior of chiral molecules.

1991 Great Britain’s Martin Medal for outstanding contributions to Chromatography

Selected Awards

1993 Presidential Award for Research and Creativity

1993 ACS 49th Regional Award

1995 R&D 100 Award

1996 A. A. Benedette-Pichler Award

1998 ACS Helen M. Free Award for Public Outreach

1999 American Chemical Society Award in Chromatography

2001 Weber Medal for Contributions to Pharmaceutical Science

2002 ACS Kenneth A. Spenser Award for Meritorious Achievement in Food & Agriculture Science

2003 Chirality Medal, Shizuoka, Japan

2004 Vladimir J. Zuffa Medal for Pharmaceutical Chemistry

2005 Dal Nogare Award for Separation Science

Editorial Recognitions

Separations Associate Editor for Analytical Chemistry.  
Former Editor of Chirality.  
Section Editor for Amino Acids.
 
Member of the Editorial Board of Journal of Pharmaceutical & Biomedical Analysis,
Amino Acids Journal
,
The Journal of Chromatography
, The Journal of Liquid Chromatography,
The Journal of Planar Chromatography,
Journal of Inclusion
Phenomena, Separation Science and Technology, and Chromatographia. 
Member of the Instrumentation Board for Analytical Chemistry, 1990. 
Member of the Scientific Advisory Board for Analytical Chemistry, 1996-98. 
1999 Editorial Advisory Board of Chromatographia,
2001 Editorial Advisory Board for Electrophoresis, Chromatographia
Journal of Separation Science.

Department of Chemistry and Biochemistry

The University of Texas at Arlington · Arlington, Texas 76019-0065 USA

Phone: 817-272-3171 | Fax: 817-272-3808

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