The University of Texas at Arlington

Jongyun Heo

Jongyun  Heo

Associate Professor

Office: 351 CPB, Email: jheo@uta.edu, Phone: 817-272-9627, FAX: 817-272-3808

Research ProfileCoursesPersonal Page

Cellular redox agents contribute to a plethora of both physiological and pathophysiological processes as they can promote DNA damage as well as oxidative inactivation or activation of certain redox-active proteins. Our research efforts focus on elucidating the mechanisms by which (i) redox-active small GTPases, including the proto-oncoprotein p21Ras (Ras), and (ii) redox-active phosphatases are regulated by redox agents.

"Superoxide Inhibits Guanine Nucleotide Exchange Factor (GEF) Action on Ras, but not on Rho, through Desensitization of Ras to GEF" Michael Wey, Vinh Phan, Gerardo Yepez, and Jongyun Heo, Biochemistry, (2014) 53: 518-532.

"Kinetic Mechanisms of Mutation-dependent Harvey Ras Activation and Their Relevance for Development of Costello Syndrome" Michael Wey, Jungwoon Lee, Soon Seog Jeong, Jungho Kim, Jongyun Heo, Biochemistry, (2013) 52: 8465-8479.

"Insight into the 6-thiopurine-mediated Termination of the Invasive Motility of Tumor Cells Derived From Inflammatory Breast Cancer" Jongyun Heo, Michael Wey, and Inpyo Hong, Biochemistry, (2011) 50: 5731-5742.

"Redox Control of GTPases: From Molecular Mechanism to Functional Significance in Health and Disease" Jongyun Heo Antioxidants & Redox Signaling, (2011) 14; 689-724.

"Ras-targeting Action of Thiopurines in the Presence of Reactive Nitrogen Species" Jongyun Heo and Inpyo Hong, Biochemistry, (2010) 49; 3965-3976.

"The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats" Raffaella Priora, Lucia Coppo, Antonios Margaritis, Danila Di Giuseppe, Simona Frosali, Domenico Summa, Jongyun Heo, and Paolo Di Simplicio, Toxicology and Applied Pharmacology, (2010) 242; 333-343.

"Redox regulation of Ran GTPase" Jongyun Heo, Biochem. Biophys. Res. Commun. 2008, 376, 568-572.

"Redox regulation of RhoA" Jongyun Heo, Kimberly W. Raines and Sharon L. Campbell, Biochemistry 2006, 45, 14481-14489.

"Ras Regulation by Reactive Oxygen and Nitrogen Species" Jongyun Heo and Sharon L. Campbell, Biochemistry 2006, 45, 2200-2210.

"Nitirc Oxide and Cell Signaling: Redox Regulation of Ras Superfamily GTPases" Jongyun Heo and Sharon L. Campbell, in Nitric Oxide, Cell Signaling, and Gene Expression, Santiago Lamas and Enrique Cadenas, Eds., Taylor & Francis Group, LLC., New York (2005).

"Mechanism of Redox-Mediated Guanine Nucleotide Exchange on Redox-Active Rho GTPases" Jongyun Heo and Sharon L. Campbell, J. Biol. Chem. 2005, 280, 31003-31010.

"Recognition and Activation of Rho GTPases By Vav1 and Vav2 Guanine Nucleotide Exchange Factors" Jongyun Heo, Roopa Thapar and Sharon L. Campbell, Biochemistry 2005, 44, 6573-6585.

"Superoxide Anion Radical Modulates the Activity of Ras and Ras-Related GTPases by a Radical-Based Mechanism Similar to that of Nitric Oxide" Jongyun Heo and Sharon L. Campbell, J.  Biol. Chem. 2005, 280, 12438-12445.

"Mechanism of Free Radical Nitric Oxide-Mediated Ras Guanine Nucleotide Dissociation" Jongyun Heo, Kirk C. Prutzman, Viorel Mocanu and Sharon L. Campbell, J. Mol. Biol. 2005, 346, 1423-1440.

"pH-Dependent Perturbation of Ras Guanine-Nucleotide Interactions and Ras-Guanine-Nucleotide Exchange" Jongyun Heo, Guanghua Gao and Sharon L. Campbell, Biochemistry 2004, 43, 10102-10111.

"Mechanism of p21Ras S-Nitrosylation and Kinetics of Nitric Oxide-Mediated Guanine Nucleotide Exchange" Jongyun Heo and Sharon L. Campbell, Biochemistry 2004, 43, 2314-2322.

"Converting the NiFeS Carbon Monoxide Dehydrogenase to a Hydrogenase and a Hydroxylamine Reductase" Jongyun Heo, Marcus T. Wolfe, Christopher R. Staples and Paul W. Ludden, J. Bacteriol. 2002, 184, 5894-5897.

"Hydroxylamine Reductase Activity of the Hybrid Cluster Protein from Escherichia coli" Marcus T. Wolfe, Jongyun Heo, John S. Garavelli and Paul W. Ludden, J. Bacteriol. 2002, 184, 5898-5902.

"CO Dehydrogenase from Rhodospirillum rubrum Produces Formate" Jongyun Heo, Lars Skjeldal and Paul W. Ludden, J. Biol. Inorg. Chem. 2002, 7, 810-814.

"Life on Carbon Monoxide: X-Ray Structure of Rhodospirillum rubrum Ni-Fe-S Carbon Monoxide Dehydrogenase at 2.8 Å Resolution" Catherine L. Drennan, Jongyun Heo, Michael D. Sintchak, Eric Schreiter and Paul W. Ludden, Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 11973-11978.

"Redox-Dependent Activity of CO Dehydrogenase from Rhodospirillum rubrum" Jongyun Heo, Cale M. Halbleib and Paul W. Ludden, Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 7690-7693.

"The Redox-Dependent CO2 Reduction Activity of CO Dehydrogenase from Rhodospirillum rubrum" Jongyun Heo, Christopher R. Staples and Paul W. Ludden, Biochemistry 2001, 40, 7604-7611.

"Evidence for a CO Ligand in CO-Dehydrogenase from Rhodospirillum rubrum that is Required for Catalytic Activity" Jongyun Heo, Christopher R. Staples, Cale M. Halblieb and Paul W. Ludden, Biochemistry 2000, 39, 7956-7963.

"Rhodospirillum rubrum CO-Dehydrogenase (Part 2).  Spectroscopic Investigation and Assignment of Spin-Spin Coupling Signals" Jongyun Heo, Christopher R. Staples, Joshua Telser and Paul W. Ludden, J. Am. Chem. Soc, 1999, 121, 11045 -11057.

"Rhodospirillum rubrum CO-Dehydrogenase (Part 1).  Spectroscopic Studies of CODH Variant C531A Indicate the Presence of a Binuclear [FeNi] Cluster" Christopher R. Staples, Jongyun Heo, Nathan J. Spangler, Robert L. Kerby, Gary P. Roberts and Paul W. Ludden, J. Am. Chem. Soc, 1999, 121, 11034 -11044.

"Regulation of 2-Carboxy-D-Arabinitol 1-Phosphatase: Activation by Glutathione and Interaction with Thiol Reagents" Jongyun Heo and Gabriel P. Holbrook, Biochem. J. 1999, 338, 409-416.

"Progress Toward the X-ray Structure Determination of R. rubrum Carbon Monoxide Dehydrogenase" Catherine L. Drennan, Nathan J. Spangler, Jongyun Heo, Paul W. Ludden and Douglas C. Rees, J. Inorg. Biochem. 1999, 74 (1-4), 118.

"Characterization of Rhodospirillum rubrum CO-Dehydrogenase" Christopher R. Staples, Jongyun Heo, Nathan J. Spangler, Robert L. Kerby, Gary P. Roberts and Paul W. Ludden, J. Inorg. Biochem. 1999, 74 (1-4), 304.

B.Sc. Sogang University, Seoul, Korea (1987)

M.Sc. Northern Illinois University (1997)

Ph.D.  University of Wisconsin-Madison, (2001)

Postdoctoral Fellow:
University of North Carolina-Chapel Hill  (2001-2006)

Department of Chemistry and Biochemistry

The University of Texas at Arlington · Arlington, Texas 76019-0065 USA

Phone: 817-272-3171 | Fax: 817-272-3808

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