The University of Texas at Arlington

Kevin A. Schug

Kevin A. Schug

Associate Professor & Shimadzu Distinguished Professor of Analytical Chemistry

Office: 358 CPB, Email: kschug@uta.edu, Phone: 817-272-3541, FAX: 817-272-3808

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Mixtures of bioactive chemical compounds require high efficiency separations and mass spectrometry techniques for their careful characterization.  Our laboratory has become particularly adept at the development of methods for quantitative analysis of small and large molecules present in trace quantities in biological fluids. With this ability, we can provide strong support of pharmaceutical, preclinical, and clinical research.  We are also currently undertaking one of the most extensive investigations of the potential impact of industrial processes, such as unconventional drilling and hydraulic fracturing, on our environment.  This includes a large focus on groundwater quality.  In our group, we strive to use the complete analytical chemistry toolbox to solve problems, including state-of-the-art sample preparation, gas chromatography, liquid chromatography, spectroscopy, and mass spectrometry techniques.  We are interested in both fundamental and applied research problems.  We work in close collaboration with many influential industry and academic partners to ensure our research is timely and relevant to today’s needs and issues.  Some specific topics of current research include development and application of:

•  An integrated instrument for simultaneous determination of small and large molecules from complex samples featuring multidimensional liquid chromatography and tandem mass spectrometry;

•  restricted access media for on-line sample preparation;

•  methods for evaluation of the potential impact of unconventional drilling processes on groundwater quality;

•  technologies for remediation of waste water; and the characterization thereof;

•  novel methods for antibacterial drug discovery, especially materials and mass spectrometric methods to stream-line discovery work-flows;

•  a new gas chromatography – vacuum ultraviolet absorption detection system;

•  higher order tandem mass spectrometry for the differentiation and elucidation of isomeric natural products and chemical degradation mechanisms.

Schug, K.A.; Sawicki, I.; Carlton Jr., D.D.; Fan, H.; McNair, H.M.; Nimmo, J.P.; Kroll, P.; Smuts, J.; Walsh, P.; Harrison, D. A Vacuum Ultraviolet Detector for Gas Chromatography. Anal. Chem. 2014, 86, 8329-8335.

Fan, H.; Papouskova, B.; Lemr, K.; Wigginton, J.G.; Schug, K.A. Bulk Derivatization and Direct Injection of Human Cerebrospinal Fluid for Trace Level Quantification of Endogenous Estrogens Using Trap-and-Elute LC-MS/MS. J. Sep. Sci. 2014, 37, 2010-2017.

Barnes, J.S.; Schug, K.A. Oxidative Degradation of Quercetin with Hydrogen Peroxide Using Continuous Flow Kinetic Electrospray – Ion Trap – Time of Flight Mass Spectrometry. J. Agric. Food Chem. 2014, 62, 4322-4331.

Fontenot, B.E.; Hunt, L.R.; Hildenbrand, Z.L.; Carlton Jr., D.D.; Oka, H.; Walton, J.L.; Hopkins, D.; Osorio, A.; Bjorndal, B.; Hu, Q.; Schug, K.A.  An evaluation of water quality in private drinking water wells near natural gas extraction sites in the Barnett Shale Formation. Environ. Sci. Technol. 2013, 47, 10032-10040.

Yang, S.H.; Wang, E.H.; Gurak, J.A.; Bhawal, S.; Deshmukh, R.; Wijeratne, A.B.; Edwards, B.L.; Foss Jr., F.W.;* Timmons, R.B.; Schug, K.A. Affinity Mesh Screen Materials for Selective Extraction and Analysis of Antibiotics using Transmission Mode Desorption Electrospray Ionization Mass Spectrometry. Langmuir 2013, 29, 8046-8053.

Li, L.; Yang, S.H.; Havlicek, V.; Lemr, K.; Schug, K.A. Continuous Flow‐ Extractive Desorption Electrospray Ionization: Analysis from “Non‐ESI‐Friendly” Solvents and Related Mechanism. Anal. Chim. Acta 2013, 769, 84-90.

Tedmon, L.; Barnes, J.S.; Nguyen, H.P.; Schug, K.A. Differentiating Isobaric Steroid Hormone Metabolites Using Multi-Stage Tandem Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2013, 24, 399-409.

Spencer, S.E.; Kim, S.Y.; Kim, S.B.; Schug, K.A. Matrix‐Assisted Laser Desorption/Ionization ‐ Time of Flight Mass Spectrometry Profiling of Trace Constituents of Condom Lubricants in the Presence of Biological Fluids.  Forensic Sci. Int. 2011, 207, 19-26.

Wijeratne, A.W.; Yang, S.H.; Armstrong, D.W.; Schug, K.A. Solvent Molecules Undergo Homolytic Cleavage and Radical Recombination Processes during Negative-Mode Electrospray Ionization: Adduct Formation with Antimony(III)-Tartrate Dianion. Anal. Chem. 2010, 82, 5141-5146.

Barnes, J.S.; Nguyen, H.P.; Shen, S.; Schug, K.A.  General Method for Extraction of Blueberry Anthocyanins and Identification Using High Performance Liquid Chromatography-Electrospray Ionization-Ion Trap-Time of Flight Mass Spectrometry  J. Chromatogr. A 2009, 1216, 4728-4735.

Fryčák, P.; Schug, K.A.  Dynamic Titration:  Determination of Dissociation Constants for Noncovalent Complexes in Multiplexed Format Using HPLC-ESI-MS. (Accelerated Article) Anal. Chem. 2008, 80, 1385-1393.

B.S. in Chemistry, College of William and Mary (1998)

Minor, Classical Civilizations

Ph.D. in Chemistry, Virginia Polytechnic Institute and State University (2002)

Adviser:  Prof. Harold M. McNair

Postdoctoral Fellow:
Institute for Analytical Chemistry, University of Vienna, Austria (2003-2005)

Adviser: Prof. Dr. Wolfgang Lindner

Kevin A. Schug is Associate Professor and Shimadzu Distinguished Professor of Analytical Chemistry in the Department of Chemistry and Biochemistry at The University of Texas at Arlington (UTA).  He is also Shimadzu Science Advisor to the Vice President for Research at UTA and an Adjunct Associate Professor in the Department of Pharmacology and Neuroscience at the University of North Texas Health Science Center. 

Dr. Schug received his B.S. degree in Chemistry in 1998 from the College of William and Mary, and his Ph.D. degree in Chemistry from Virginia Tech in 2002 under the supervision of Prof. Harold M. McNair.  From 2003-2005, he performed post-doctoral research in the laboratory of Prof. Dr. Wolfgang Lindner at the University of Vienna in Austria. 

Since joining UTA in 2005, his research has been focused on the theory and application of separation science and mass spectrometry for solving a variety of analytical and physical chemistry problems.  Two main research threads are currently pursued with some intertwined aspects:  1) Fundamental studies of chromatographic separations and mass spectrometry ionization mechanisms; and 2) isolation, characterization, and trace analysis of bioactive compounds in complex matrices.  His group is also active in chemical education research.  Financial support for chemistry and educational research is from UTA, Eli Lilly and Company, that National Institutes of Health, the National Science Foundation, Texas Parks and Wildlife Department, Shimadzu Scientific Instruments, Inc., and other industry partners.  He has 78 peer-reviewed publications and over 250 presentations, posters, and invited talks to his group’s credit.  Over the course of nine years at UTA he has been PI or co-PI on $5.5-Million in external grant support, contracts, and awards; he has further contributed to capturing $17.8-Million in development support, which have been used to create the Shimadzu Center for Advanced Analytical Chemistry (www.uta.edu/scaac) and the Shimadzu Institute for Research Technologies at UTA.

Dr. Schug is Founder and Director of a K-12 science outreach program Diversity in Science in the United States (www.discusprogram.com).  He is the institutional founder and steering committee member for the Organizational Network for Teaching as Research Advancement and Collaboration (ON-TRAC; https://grad.uta.edu/ontrac) at UTA, an affiliate of the nationwide Center for Integration of Research Teaching and Learning (CIRTL) preparing future faculty program. He is a project leader in UTA’s National Science Foundation STEM Talent Expansion Program (STEP), which focuses on efforts to improve retention and graduation rates of STEM students (www.uta.edu/auras). Through these, Dr. Schug’s efforts touch virtually every level of the U.S. STEM education system.

Dr. Schug has received the 2009 Emerging Leader in Chromatography award given by LCGC magazine, an NSF CAREER award, the 2009 Eli Lilly and Company ACACC Young Investigator Award in Analytical Chemistry, and the 2013 American Chemical Society Division of Analytical Chemistry Young Investigator in Separation Science Award. For his teaching, he received the 2014 University of Texas System Regents’ Outstanding Teaching Award. He is a member of the Editorial Advisory Board of LCGC Magazine (Advanstar) and Analytica Chimica Acta (Elsevier). He is a Senior Editor for Journal of Separation Science (Wiley).  He writes a regular blog for LCGC On-line (www.chromatographyonline.com/lcgc) on various aspects of separation science, which is promoted and subscribed to across the world.

2009, Emerging Leader in Chromatography Award (sponsored by LCGC Magazine)

2009, Eli Lilly and Company Young Investigator Award in Analytical Chemistry

2009 - 2014, National Science Foundation CAREER Award

2010, U.T. Arlington, College of Science Research Excellence Award

2010, Outstanding Mentor Award, Sigma Xi Honor Society (U.T. Arlington chapter)

2011, Outstanding Mentor Award, Sigma Xi Honor Society (U.T. Arlington chapter)

2012, Outstanding Mentor Award, Sigma Xi Honor Society (U.T. Arlington chapter)

2013, Outstanding Mentor Award, Sigma Xi Honor Society (U.T. Arlington chapter)

2013, American Chemical Society, Division of Analytical Chemistry Young Investigator in Separation Science Award

2014, Outstanding Reviewer of the Year, Journal of the American Society for Mass Spectrometry

2014, U.T. Arlington College of Science Teaching Excellence Award

2014, University of Texas System Regent’s Outstanding Teaching Award

Department of Chemistry and Biochemistry

The University of Texas at Arlington · Arlington, Texas 76019-0065 USA

Phone: 817-272-3171 | Fax: 817-272-3808

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