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Jongyun Heo |
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Biochemistry
Assistant Professor B.Sc. Sogang University, Seoul, Korea (1987)M.Sc. Northern Illinois University (1997) Ph.D. University of Wisconsin-Madison, (2001) Postdoctoral Fellow:
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Phone: 817-272-1076 FAX: 817-272-3808 E-mail: jheo@uta.edu Office: 352 CPB Personal Page |
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RESEARCH INTERESTS Cellular redox agents contribute to a plethora of both physiological and pathophysiological processes as they can promote DNA damage as well as oxidative inactivation or activation of certain redox-active proteins. Our research efforts focus on elucidating the mechanisms by which (i) redox-active small GTPases, including the proto-oncoprotein p21Ras (Ras), and (ii) redox-active phosphatases are regulated by redox agents. Redox-Mediated
Cellular Signaling Events
(Click images to enlarge) It is well known that Ras is redox active and aberration of Ras activity can lead to an increase in the amount of the biologically active form of Ras which can promote uncontrolled cell growth.
It is also well known that Ras is the most prevalent oncoprotein found in human cancer. Similar to Ras and Rho GTPases, other phosphatases and kinases initiate various cellular signaling pathways.
Many phosphatases and kinases are also redox active, and perturbation of their redox signals often induces unchecked cell proliferation. Research Approach
Representative Publications: "Redox regulation of Ran GTPase"
Jongyun Heo, Biochem. Biophys. Res. Commun. 2008, 376,
568-572. "Redox
regulation of RhoA" Jongyun
Heo, Kimberly W. Raines and Sharon L. Campbell, Biochemistry
2006, 45, 14481-14489. "Ras
Regulation by Reactive Oxygen and Nitrogen Species"
Jongyun Heo and Sharon L. Campbell, Biochemistry 2006, 45,
2200-2210. "Nitirc Oxide and
Cell Signaling: Redox Regulation of Ras Superfamily GTPases" Jongyun
Heo and Sharon L. Campbell, in Nitric Oxide, Cell Signaling, and Gene
Expression, Santiago Lamas and Enrique Cadenas, Eds., Taylor &
Francis Group, LLC., New York (2005). "Mechanism of
Redox-Mediated Guanine Nucleotide Exchange on Redox-Active Rho GTPases"
Jongyun Heo
and Sharon L. Campbell,
J. Biol. Chem. 2005, 280, 31003-31010. "Recognition and
Activation of Rho GTPases By Vav1 and Vav2 Guanine Nucleotide Exchange
Factors" Jongyun Heo, Roopa Thapar and Sharon L. Campbell, Biochemistry
2005, 44, 6573-6585. "Superoxide Anion
Radical Modulates the Activity of Ras and Ras-Related GTPases by a
Radical-Based Mechanism Similar to that of Nitric Oxide" Jongyun Heo
and Sharon L. Campbell, J. Biol.
Chem. 2005, 280,
12438-12445. "Mechanism of Free
Radical Nitric Oxide-Mediated Ras Guanine Nucleotide Dissociation"
Jongyun Heo, Kirk C. Prutzman, Viorel Mocanu and Sharon L. Campbell, J.
Mol. Biol. 2005, 346, 1423-1440. "pH-Dependent
Perturbation of Ras Guanine-Nucleotide Interactions and Ras-Guanine-Nucleotide Exchange" Jongyun Heo, Guanghua Gao and Sharon
L. Campbell, Biochemistry 2004, 43, 10102-10111. "Mechanism of p21Ras
S-Nitrosylation and Kinetics of Nitric Oxide-Mediated Guanine Nucleotide
Exchange" Jongyun Heo and Sharon L. Campbell, Biochemistry 2004,
43, 2314-2322. "Converting
the NiFeS Carbon Monoxide Dehydrogenase to a Hydrogenase and a Hydroxylamine
Reductase" Jongyun
Heo, Marcus T. Wolfe, Christopher R. Staples and Paul W. Ludden,
J. Bacteriol. 2002, 184, 5894-5897. "Hydroxylamine
Reductase Activity of the Hybrid Cluster Protein from Escherichia coli"
Marcus T. Wolfe, Jongyun Heo, John
S. Garavelli and Paul W. Ludden, J. Bacteriol. 2002,
184, 5898-5902. "CO Dehydrogenase
from Rhodospirillum rubrum
Produces Formate" Jongyun Heo, Lars Skjeldal and Paul W. Ludden, J.
Biol. Inorg. Chem. 2002, 7, 810-814. "Life on Carbon
Monoxide: X-Ray Structure of Rhodospirillum
rubrum Ni-Fe-S Carbon Monoxide Dehydrogenase at 2.8 Å Resolution"
Catherine L. Drennan, Jongyun Heo, Michael D. Sintchak, Eric Schreiter and
Paul W. Ludden, Proc. Natl. Acad. Sci. U. S. A. 2001, 98,
11973-11978. "Redox-Dependent
Activity of CO Dehydrogenase from Rhodospirillum
rubrum" Jongyun Heo, Cale M. Halbleib and Paul W. Ludden, Proc.
Natl. Acad. Sci. U. S. A. 2001, 98, 7690-7693. "The
Redox-Dependent CO2 Reduction Activity of CO Dehydrogenase from Rhodospirillum
rubrum" Jongyun Heo, Christopher R. Staples and Paul W. Ludden, Biochemistry 2001, 40, 7604-7611. "Evidence for a CO
Ligand in CO-Dehydrogenase from Rhodospirillum
rubrum that is Required for Catalytic Activity" Jongyun Heo,
Christopher R. Staples, Cale M. Halblieb and Paul W. Ludden, Biochemistry 2000, 39,
7956-7963. "Rhodospirillum rubrum CO-Dehydrogenase (Part 2).
Spectroscopic Investigation and Assignment of Spin-Spin Coupling
Signals" Jongyun Heo, Christopher R. Staples, Joshua Telser and Paul W.
Ludden, J. Am. Chem. Soc, 1999, 121, 11045 -11057. "Rhodospirillum rubrum CO-Dehydrogenase (Part 1).
Spectroscopic Studies of CODH Variant C531A Indicate the Presence of
a Binuclear [FeNi] Cluster" Christopher R. Staples, Jongyun Heo, Nathan
J. Spangler, Robert L. Kerby, Gary P. Roberts and Paul W. Ludden, J.
Am. Chem. Soc, 1999, 121, 11034 -11044. "Regulation of
2-Carboxy-D-Arabinitol 1-Phosphatase: Activation by Glutathione and
Interaction with Thiol Reagents" Jongyun Heo and Gabriel P. Holbrook, Biochem.
J. 1999, 338, 409-416. "Progress Toward
the X-ray Structure Determination of R. rubrum Carbon Monoxide
Dehydrogenase" Catherine L. Drennan, Nathan J. Spangler, Jongyun Heo,
Paul W. Ludden and Douglas C. Rees, J. Inorg. Biochem. 1999, 74
(1-4), 118. "Characterization of Rhodospirillum rubrum CO-Dehydrogenase" Christopher R. Staples, Jongyun Heo, Nathan J. Spangler, Robert L. Kerby, Gary P. Roberts and Paul W. Ludden, J. Inorg. Biochem. 1999, 74 (1-4), 304.
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Department of Chemistry and Biochemistry |
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