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Christopher J. O’Brien |
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Organic
Chemistry
Assistant Professor B.Sc.
University of
Manchester
Institute of Science and Ph.D. University of Sheffield (2000) Postdoctoral Fellow, Glasgow University (2002)
Senior Postdoctoral Fellow, York University, Toronto (2003- |
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Phone: 817-272-0262 FAX: 817-272-3808 E-mail: cobrien@uta.edu Office: 203 CRB Personal Page |
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RESEARCH INTERESTS Transition-metal
and organocatalyses
Selected
Recent Publications: Biaryls
Made Easily: PEPPSI and the Kumada-Tamao-Corriu Reaction: Organ,
M. G.; Abdel-Hadi, M; Avola, S; Hadei, N; Nasielski, J; O’Brien C. J.;
Valente, C. Chem. Eur. J. 2007, 13, 150-157. Pd-N-Heterocyclic
Carbene (NHC) Catalysts for Cross-coupling Reactions: The
Synthetic Chemists’ Perspective: Kantchev, E. A. B.; O’Brien C. J.;
Organ, M. G. Angew. Chem. Int. Ed. 2007, 46,
2768-2813. Pd-N-Heterocyclic
Carbene (NHC) Catalysts for Cross-Coupling Reactions: Kantchev, E.
A. B.; O’Brien C. J.; Organ, M. G. Aldrichimica Acta,
2006, 39, 93 (Invited article). A
User-Friendly, All Purpose Pd-NHC Precatalyst for the Negishi Reaction:
A Step towards an Universal Cross-coupling Catalyst: Organ, M. G.;
Avola, S.; Dubovyk, I.; Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J.;
Valente, C. Chem. Eur. J. 2006, 12, 4749-4755. Easily
Prepared Air and Moisture Stable Pd-NHC Complexes: A Reliable
User-Friendly Highly Active Palladium Precatalyst for the Suzuki-Miyaura
Reaction: O’Brien, C. J.; Kantchev, E. A. B.; Hadei, N.;
Valente, C.; Chass, G. A.; Lough, A.; Hopkinson, A. C.; Organ, M. G. Chem.
Eur. J. 2006, 12, 4743-4748. Room-Temperature
Negishi Cross-Coupling of Unactivated Alkyl Bromides with Alkyl
Organozinc Reagents Utilizing a Pd/N-Heterocyclic Carbene Catalyst:
Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J.; Organ, M. G. J.
Org. Chem. 2005, 70, 8503-8507. Towards
the Rational Design of Palladium-N-heterocyclic Carbene Catalysts by a
Combined Experimental and Computational Approach: O’Brien, C.
J.; Kantchev, E. A. B.; Chass, G. A.; Hadei, N.; Hopkinson, A. C.;
Organ, M. G.; Setiadi, D. H.; Tang, T-H; Fang, D-C. Tetrahedron 2005,
61, 9723-9735 (Invited article). The
First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a
Pd-N-Heterocyclic Carbene (NHC) Catalyst: Hadei, N.; Kantchev, E.
A. B.; O’Brien, C. J.; Organ, M. G. Org. Lett. 2005,
7, 3805-3807. Electronic
Nature of N-Heterocyclic Carbene Ligands: Effect on the Suzuki Reaction:
Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J.; Organ, M. G. Org. Lett.
2005, 7, 1991-1994. Additions
of stabilised and semi-stabilised sulfur ylides to tosyl protected
imines: are they under kinetic or thermodynamic control?:
Aggarwal; V. K.; Charmant, J. P. H.; Ciampi, C.; Hornby, J. M.;
O’Brien, C. J.; Hynd, G.; Parsons, R. J. Chem. Soc., Perkin Trans.
1, 2001, 3159-3166. Scope
and limitations in sulfur ylide mediated catalytic asymmetric
aziridination of imines: use of phenyldiazomethane, diazoesters and
diazoacetamides: Aggarwal; V. K.; Ferrara, M; O’Brien, C. J.;
Thompson, A; Jones, R. V. H.; Fieldhouse, R. J. Chem. Soc., Perkin
Trans. 1, 2001, 1635-1643.
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Department of Chemistry and Biochemistry |
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