Dr. Yuan Bo Peng
Associate Professor

Room 503, Life Sciences Bldg.
Phone: (817) 272-5222
Email: ypeng@uta.edu

Class Notes - WebCT

Syllabus - Fall 2007

Description of Research

Physiological mechanisms of pain

I am interested in studying the neurophysiological mechanisms of sensory transmission, especially, nociception by means of electrophysiological techniques in both peripheral and central nervous system. 

Our current projects include: (1) Dorsal root reflexes in peripheral inflammation; (2) Cortical modulation of spinal dorsal horn neuronal activity; (3) Pain mechanisms of experimental autoimmune encephalomyelitis; (4) Detection of neuronal activities by optic spectroscopy; (5) Development and application of telemetry system for recording and stimulating in the nervous system.

Representative Publications

1. Gatchel RJ, Peng YB, Peters ML, Fuchs PN, Turk D: The biopsychosocial approach to chronic pain: scientific advances and future directions. Psychol Bull. 2007 Jul;133(4):581-624.
2. Radhakrishnan H, Liu H, Senapati AK, and Peng YB: Determination of hemoglobin oxygen saturation in rat sciatic nerve by in vivo near infrared spectroscopy. Brain Res Brain Res. 2006 Jun 16; [ Epub ahead of print].
3. Radhakrishnan H, Senapati AK, Kashyap D, Peng YB, and Liu H: Light scattering from rat nervous system measured in vivo by near infrared reflectance spectroscopy J Biomed Opt. 2005 Sep-Oct;10(5):051405.
4. Senapati AK, Huntington PJ, Lagraize SC, Wilson HD, Fuchs PN, Peng YB: Electrical stimulation of the primary somatosensory cortex inhibits spinal dorsal horn neuron activity. Brain Res. 2005 Sep 28;1057(1-2):134-40.
5. LaGraize SC, Borzan J, Peng YB, Fuchs PN: Selective regulation of pain affect following activation of the opioid anterior cingulate cortex system. Exp Neurol. 2006 Jan;197(1):22-30.
6. Senapati AK, Lagraize SC, Huntington PJ, Wilson HD, Fuchs PN, Peng YB: Electrical stimulation of the anterior cingulate cortex reduces responses of rat dorsal horn neurons to mechanical stimuli. J Neurophysiol. 2005 Jul;94(1):845-51.
7. Borzan J, LaGrazia SC, Hawkins DL, and Peng YB: Dorsal horn neuron response patterns to graded heat stimuli in rat. Brain Res 1045(1-2):72-9, 2005.
8. Senapati AK, Huntington PJ, and Peng YB: Spinal dorsal horn neuron response to mechanical stimuli is decreased by electrical stimulation of the primary motor cortex. Brain Res. 1036 (1-2): 173-179, 2005.
9. Senapati AK, Radhakrishnan H, Liu H, and Peng YB: Detection of degeneration in rat sciatic nerve by in vivo near infrared spectroscopy. Brain Res Brain Res Protoc. 14 (2):119-125, 2005.
10. Peng YB, Ringkamp M, Meyer RA, and Campbell JN: Fatigue and paradoxical enhancement of heat response in C-fiber nociceptors from cross-modal excitation. J Neurosci. 23(11):4766-74, 2003.
11. Peng YB, Kenshalo DR, Gracely RH: Periaqueductal gray-evoked dorsal root reflex is frequency dependent. Brain Res. 976: 217-226, 2003.
12. Peng YB, Ling QD, Ruda MA, Kenshalo, DR. Jr. Electrophysiological changes in adult rat dorsal horn neurons after neonatal peripheral inflammation. J Neurophysiol 90: 73-80, 2003.
13. Ringkamp M, Peng YB, Wu G, Hartke TV, Campbell JN, and Meyer RA: Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors. J Neurosci 21(12):4460-4468, 2001.
14. Peng YB, Wu J, Willis WD, Kenshalo D: GABA(A) and 5-HT(3) receptors are involved in dorsal root reflexes: possible role in periaqueductal gray descending inhibition. J Neurophysiol. Jul;86(1):49-58, 2001
15. Ruda MA, Ling QD. Hohmann AG, Peng YB and Tachibana T. Neonatal peripheral inflammation alters nociceptive neuronal circuits. Science 289: 628-630, 2000.
16. Peng YB, Ringkamp M, Campbell JN, and Meyer RA: Electrophysiological assessment of the cutaneous arborization of A-delta fiber nociceptors. J. Neurophysiol. 82: 1164-1177, 1999.
17. Lin Q, Wu J, Peng YB, Cui M and Willis WD: Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is modulated by guanosine 3',5'-cyclic monophosphate. J Neurophysiol 81: 1095-1103, 1999.
18. Lin Q, Wu J, Peng YB, Cui M and Willis WD: Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons. J Neurophysiol 81: 1086-1094, 1999.
19. Lin Q, Palecek J, Paleckova V, Peng YB, Wu J, Cui M and Willis WD: Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. J Neurophysiol 81: 1075-1085, 1999.
20. Lin Q, Peng YB, Wu J and Willis WD: Involvement of cGMP in nociceptive processing and sensitization of spinothalamic neurons in primates. J Neurosci 17:3293-3302, 1997.
21. Peng YB, Lin Q, and Willis WD: Involvement of protein kinase C in responses of rat dorsal horn neurons to mechanical stimuli and PAG descending inhibition. Exp Brain Res 114: 561-570, 1997.
22. Lin Q, Peng YB and Willis WD: Inhibition of primate spinaothalamic tract neurons by spinal glycine and GABA is reduced during central sensitization. J Neurophysiol 75: 1005-1014, 1996.
23. Peng YB, Lin Q, and Willis WD: Effects of GABA and glycine antagonists on the activity and PAG-induced inhibition of rat dorsal horn neurons. Brain Res 736: 189-201, 1996.
24. Lin Q, Peng YB and Willis WD: Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons. J Neurosci 16: 3026-3034, 1996.
25. Peng YB, Lin Q, and Willis WD: Involvement of Alpha2-adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats. J Pharmacol Exp Ther 278:125-135, 1996.
26. Peng YB, Lin Q, and Willis WD. The role of 5-HT3 receptors in periaqueductal gray-induced inhibition of nociceptive dorsal horn neurons in rat. J Pharmacol Exp Ther 276: 116-124, 1996.
27. Lin Q ,  Peng YB and Willis WD: Antinociception and inhibition from the periaqueductal gray are mediated in part by spinal 5HT_1A receptors. J Pharmacol Exp Ther 276: 958-967, 1996.
28. Lin Q, Peng YB and Willis WD: Role of GABA receptor subtypes in inhibition of primate spinothalamic tract neurons: difference between spinal and periaqueductal gray inhibition. J Neurophysiol 75: 109-123, 1996.
29. Tewari K, Simard JM, Peng YB, Werrbach-Perez K and Perez-Polo JR: Acetyl-L-carnitine arginyl amide (ST857) increases calcium channel density in rat pheochromocytoma (PC12) cells. J Neurosci Res 40: 371-378, 1995.
30. Lin Q, Peng YB, and Willis WD: Glycine and GABA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray. Brain Research 654:286-302, 1994.

Links

Social interaction lab