Dr. Julian G. Hurdle

Julian Hurdle

Assistant Professor of Biology
MAJOR AREA: Molecular Microbiology and Bacterial Infectious Diseases
OFFICE: 332 Engineering Research Building
PHONE:  817-272-2986
LAB: ERB 376
PHONE: 817-272-2986
FAX: 817-272-2855
 PhD: University of Leeds, United Kingdom (2005)

Research in my laboratory involves characterizing the molecular action of antimicrobial agents on target bacteria; determining genetic mechanisms by which bacterial pathogens resist antibiotic killing; and evaluating new ways to treat drug-resistant pathogens. Bacterial pathogens are a major cause of morbidity and mortality worldwide. Notable examples are Methicillin resistant Staphylococcus aureus and Clostridium difficile. S. aureus has a keen propensity to form biofilms, which are responsible for many stubborn medical device infections. Using microbiological techniques, animal models, transcriptional arrays, gene knockouts and anti-sense knockdown strategies we are determining whether the membrane and gene components involved in redox homeostasis are Achilles heels of biofilms. This could lead to a new understanding of how to counteract these diseases. C. difficile is the most common cause of diarrhea and a leading cause of death in hospitalized elderly patients. We are evaluating a new class of antibiotics against this pathogen using various microbiological and molecular techniques that will lead to need compounds with novel modes of action. Since C. difficile infections frequently relapse, we are also probing the microbiological basis for recalcitrance by this organism. My group adopts an inter-disciplinary collaborative approach to our discovery efforts. If you are interested in antimicrobial microbiology and bacterial infectious diseases and would like to join my group, please email me at hurdle@uta.edu for more information.