The University of Texas at Arlington

                 Daniel W. Armstrong

Analytical and Biological Chemistry

Robert A. Welch Chair in Chemistry


            Phone:
     817-272-0632

             FAX:
      817-272-0619

            E-mail:
   sec4dwa@uta.edu

        Office:
     Room 303 CRB

 

      Personal page

B.Sc. Washington and Lee University (1972)

M.S. in Oceanography,
Texas A&M University (1974)

Ph.D. in Bio-Organic Chemistry,
Texas A&M University (1977)

Caldwell Distinguished Professor, 
Iowa State University (2000-2005)

 

Selected Awards

1991 Great Britain’s Martin Medal for outstanding contributions to Chromatography
1993 Presidential Award for Research and Creativity
1995 R&D 100 Award
1999 American Chemical Society Award in Chromatography
2001 Weber Medal for Contributions to Pharmaceutical Science
2003 Chirality Medal, Shizuoka, Japan
2004 Vladimir J. Zuffa Medal for Pharmaceutical Chemistry
2005 Dal Nogare Award for Separation Science

Editorial Recognitions

Editor of Chirality.  Section Editor for Amino Acids.  Separations Associate Editor for Analytical Chemistry.  Member of the Editorial Board of Journal of Pharmaceutical & Biomedical Analysis, Amino Acids Journal, The Journal of Chromatography, The Journal of Liquid Chromatography, The Journal of Planar Chromatography, Journal of Inclusion Phenomena, Separation Science and Technology, and Chromatographia.  Member of the Instrumentation Board for Analytical Chemistry, 1990.  Member of the Scientific Advisory Board for Analytical Chemistry, 1996-98.  1999 Editorial Advisory Board of Chromatographia, 2001 Editorial Advisory Board for Electrophoresis, Chromatographia, Journal of Separation Science.

 

RESEARCH INTERESTS

Dan Armstrong has over 330 publications, including twenty book chapters, one book ("Use of Ordered Media in Chemical Separations") and eight patents.  He has been named by the Scientific Citation Index as one of the world’s most highly cited scientists, and he has given over 350 invited seminars and colloquia worldwide.  Daniel Armstrong is considered the "Father" of micelle and cyclodextrin-based separations, he elucidated the first chiral recognition mechanism by cyclodextrins, he was the first to develop macrocyclic antibiotics as chiral selectors, and he is one of the world's leading authorities on the theory, mechanism, and use of enantioselective molecular interactions.  Over 30 different LC and GC columns that were originally developed in his laboratories have been commercialized and/or copied worldwide.  His work and columns were in part responsible for the chromatography and electrophoresis-lead revolution in chiral separations over the last one and one half decades.  Currently, the columns, chiral selectors and techniques he developed dominate the world of analytical enantiomeric separations.  Recently, he developed the first high efficiency CE separation approach for microorganisms (i.e., bacterial, viruses, fungi, etc.).  This will extend the realm of separation science into the mainstream of biology and colloid science.  He also has developed the most effective way to characterize the solvent properties of room temperature ionic liquids (RTILs).  This has proven to be an essential and effective way to explain the effect of RTILs on organic reactions, and in various analytical methodologies.  Surfactant aggregation to form normal micelles in RTILs was demonstrated.  The first MALDI-MS matrices and high stability GC stationary phases were also developed.  Most recently, chiral RTILs have been shown to produce enantiomeric excesses from racemates and prochiral molecules via solvation effects.  These solvation effects also change the luminescence behavior of chiral molecules.

Representative Publications:

“Maristentorin, a Novel Pigment from the Positively Phototactic Marine Ciliate Maristentor dinoferus, is Structurally Related to Hypericin and Stentorin”, Mukherjee, P., Fulton, D.B., Halder, M., Han, X., Armstrong, D.W., Petrich, J.W., and Lobban, C.S.  J. Phys. Chem. B. 10 (12), 6359 - 6364 (2006).

“Theory and Use of the Pseudophase Model in Gas-Liquid Chromatographic Enantiomeric Separations”, Pino, V., Lantz, A. W., Anderson, J. L., Berthod, A., and Armstrong, D.W  Analytical. Chemistry 78, 113-119  (2006).

“Immobilized Ionic Liquids as High-Selectivity/High-Temperature/
High-Stability Gas Chromatography Stationary Phases”,  Anderson, J. and Armstrong, D.W. 
Analytical Chemistry  77(19), 6453-6462, (2005).

“Using Geminal Dicationic Ionic Liquids as Solvents for High Temperature Organic Reactions”,  Han, X. and Armstrong, D.W.  Organic Letters  7(19), 4205-4208, (2005).

“Gas-Phase Ion Association Provides Increased Selectivity and Sensitivity for Measuring Perchlorate by Mass Spectrometry”, Ding, J., Desai, M., and Armstrong, D.W.  Analytical Chemistry  77(15), 4829-4835, (2005).

“Chiral Ionic Liquids: Synthesis and Applications”, Ding, J. and Armstrong, D.W.  Chirality, 17(5), 281-292  (2005).

“Uptake and Enantioselective Elimination of Chlordane Compounds by Common Carp (Cyprinus carpio, L.)”, Berthod, A, Seemamahannop, R., Maples, M., Shubhi, K., and Armstrong, D.W.   Chemosphere, 59(4), 493-500  (2005).

“Pharmacokinetics and Pharmacodynamics of Theanine Enantiomers in Rats”,  Desai, M.J., Gill, M.S., Hsu, W.H., and Armstrong, D.W.  Chirality, 17(3), 154-162  (2005).

”Use of Chiral Ionic Liquids as Solvents for the Enantioselective Photoisomerization of Dibenzobicyclo[2.2.2] Octatrienes”,  Ding, J., Desikan, V., Han, X., Xiao, T.L., Ding, R., Jenks, W.S., and Armstrong, D.W.  Org. Lett.  7(2), 335-337  (2005).

“Structure and Properties of High Stability Geminal Dicationic Ionic Liquids”,  Anderson, J.L., Ding, R., Ellern, A., and Armstrong, D.W.  J. Am. Chem. Soc. 127(2),  593-604  (2005).

“Separation and Analysis of Colloidal/Nano-Particles Including Microorganisms by Capillary Electrophoresis: A Fundamental Review”, Rodriguez, M.A., and Armstrong, D.W.  J. Chromatogr. B  800, 7-25  (2004).

“New Particle-Loaded Monoliths for Chiral Capillary Electrochromatographic Separation”, Schmid, M.G., Koidl, J., Freigassner, C., Tahed, S., Wojcik, L., Beesley, T., Armstrong, D. W., and Guebitz, G.  Electrophoresis  25(18-19),  3195-3203 (2004).

“Transforming Chiral Liquid Chromatography Methodologies into More Sensitive Liquid Chromatography-Electrospray Ionization Mass Spectrometry without Losing Enantioselectivity”,  Desai, M., and Armstrong, D.W.  J. Chroma A  1035(2),  203-210 (2004).

“Chiral Ionic Liquids as Stationary Phases in Gas Chromatography”, Ding. J., Welton, T. and Armstrong, D.W.  Anal. Chem.  76(22),  6819-6822 (2004).

“Selective Separations of Peptides with Sequence Deletions, Single Amino Acid Polymorphisms, and/or Epimeric Centers Using Macrocyclic Glycopeptide Liquid Chromatography Stationary Phases”,  Zhang, B., Soukup, R., and Armstrong, D.W.  J. Chroma. A  1053(1-2),  89-99 (2004).

“Dynamic Solvation in Room Temperature Ionic Liquids”, Chowdhury, P.K., Halder, M., Sanders, L., Calhoun, T., Anderson, J.L., Armstrong, D.W., Song, X., and Petrich, J.W.,  J. Phys. Chem. B  108,  10245-10255 (2004).

Surfactant Solvation Effects and Micelle Formation in Ionic Liquids”,    Anderson, J.L.,  Pino, V., Hagberg, E.C.,  Sheares, V.V., and Armstrong, D.W.  Chem. Comm. (Cambridge, United Kingdom)  (19),  2444-2445  (2003).

Pore Exclusion Chromatography-Inductively Coupled Plasma-Mass Spectrometry for Monitoring Elements in Bacteria: A Study on Microbial Removal of Uranium from Aqueous Solution”.    Zhang,B., Li, F., Houk, R. S., and Armstrong, D.W.  Anal. Chem.  75(24),  6901-6905  (2003).

Determination of the Interconversion Energy Barrier of Enantiomers by Separation Methods”,  Krupcik, J., Oswald, P., Majek, P., Sandra, P., and Armstrong, D. W.  J. of Chromatogr. A. 1000(1-2),  779-800 (2003).

Electrophoretic Behavior and Potency Assessment of Boar Sperm Using a Capillary Electrophoresis-Laser Induced Fluorescence System”,  He, L., Jepsen, R.J., Evans, L.E., and Armstrong, D.W.  Anal. Chem. 75(4),  825-834 (2003).

Ionic Matrices for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Detection of DNA Oligomers”,  Carda-Broch, S., Berthod, A., and Armstrong, D. W.  Rap. Comm. in Mass Spec.  17(6), 553-560 (2003).

“Assignment of Absolute Configuration of a Chiral Phenyl-Substituted Dihydrofuroangelicin”,  Pescitelli, G., Berova, N., Xiao, T. L., Rozhkov, R. V., Larock, R. C., and Armstrong, D. W.  Org. & Biomol. Chem.  1(1), 186-190 (2003).

"Mechanistic Aspects in the Generation of Apparent Ultrahigh Efficiencies for Colloidal (Microbial) Electrokinetic Separations", Armstrong, D.W., He, L., Girod, M., Wei, W., and Yeung, E.S. Anal. Chem. 74(21) 5523-5530 (2002).

"Characterizing Ionic Liquids On the Basis of Multiple Solvation Interactions", Anderson, J.L., Ding, J., Welton, T., and Armstrong, D.W.  J. of the Amer.  Chem.  Soc. 124(47),  14247-14254 (2002).

"Super/Subcritical Fluid Chromatography Chiral Separations with Macrocyclic Glycopeptide Stationary Phases", Liu, Y., Berthod, A., Mitchell, C., Xiao, T.L., Zhang, B., and Armstrong, D.W.  J. of Chromatogr. A. 978(1-2) 185-204 (2002).

"A Potent Enantioselective Auxin: Indole-3-Succinic Acid", Armstrong, D.W., Liu, Y-S., He, L., Ekborg-Ott, K., Barnes, C. L., and Hammer, C.F.  J. Agri. and Food Chem.  50(3), 473-476 (2002).

"Determination of Cell Viability in Single or Mixed Samples Using Capillary Electrophoresis Laser-induced Fluorescence Microfluidic Systems", Armstrong, D.W and He, L. Anal. Chem. 73, 4551-4557 (2001).

"Ionic Liquids as Matrices for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry", Armstrong, D.W., Zhang, L.-K., He, L., and Gross, M.  Anal. Chem. 73, 3679-3686 (2001).

"Separating Microbes in the Manner of Molecules: I. Capillary Electrokinetic Approaches", D.W. Armstrong, G. Schulte, J.M. Schneiderheinze and D.J. Westenberg, Anal. Chem., 71, 5465-5469 (1999).

“Examination of Ionic Liquids and Their Interactions with Molecules, When Used as Stationary Phases in Gas Chromatography, Daniel W. Armstrong, Lingfeng He, and Yan-Song Liu, Anal. Chem., 71, 3873-3876 (1999).

 

Acknowledgment:
Our work has been supported in part by the NIH, State Department, Glaco-SmithKline, Caldwell Fund, Pfizer, and the Welch Foundation.

 

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Department of Chemistry and Biochemistry
The University of Texas at Arlington
Arlington, Texas 76019-0065, USA

Phone:  (817) 272-3171

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