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Daniel W. Armstrong |
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Analytical
and Biological Chemistry
Robert A. Welch Chair in Chemistry
B.Sc. Washington and Lee University (1972) M.S. in Oceanography, Texas A&M University (1974) Ph.D. in Bio-Organic Chemistry, Texas A&M University (1977) Caldwell Distinguished Professor, Iowa State
University |
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Phone: 817-272-0632 FAX: 817-272-0619 E-mail: sec4dwa@uta.edu Office: 303 CRB Personal Page |
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Selected
Awards 1991 Great Britain’s
Martin Medal for outstanding contributions to Chromatography Editorial Recognitions Separations
Associate Editor for Analytical Chemistry. Former
Editor of Chirality. Section
Editor for Amino Acids.
Member of the
Editorial Board of Journal of
Pharmaceutical & Biomedical Analysis, Amino
Acids Journal, The Journal of
Chromatography, The Journal
of Liquid Chromatography, The
Journal of Planar Chromatography, Journal of Inclusion Phenomena, Separation Science and Technology, and Chromatographia.
Member of the Instrumentation Board for Analytical
Chemistry, 1990. Member
of the Scientific Advisory Board for Analytical
Chemistry, 1996-98. 1999
Editorial Advisory Board of Chromatographia,
2001 Editorial Advisory Board for Electrophoresis,
Chromatographia, Journal of Separation Science. RESEARCH INTERESTS Dan Armstrong has over 450 publications, including twenty-two book chapters, one book ("Use of Ordered Media in Chemical Separations") and eleven patents. He has been named by the Scientific Citation Index as one of the world’s most highly cited scientists, and he has given over 420 invited seminars and colloquia worldwide. Daniel Armstrong is considered the "Father" of micelle and cyclodextrin-based separations, he elucidated the first chiral recognition mechanism by cyclodextrins, he was the first to develop macrocyclic antibiotics as chiral selectors, and he is one of the world's leading authorities on the theory, mechanism, and use of enantioselective molecular interactions. Over 30 different LC and GC columns that were originally developed in his laboratories have been commercialized and/or copied worldwide. His work and columns were in part responsible for the chromatography and electrophoresis-lead revolution in chiral separations over the last two and one half decades. Currently, the columns, chiral selectors and techniques he developed dominate the world of analytical enantiomeric separations. Recently, he developed the first high efficiency CE separation approach for microorganisms (i.e., bacterial, viruses, fungi, etc.). This will extend the realm of separation science into the mainstream of biology and colloid science. He also has developed the most effective way to characterize the solvent properties of room temperature ionic liquids (RTILs). This has proven to be an essential and effective way to explain the effect of RTILs on organic reactions, and in various analytical methodologies. Surfactant aggregation to form normal micelles in RTILs was demonstrated. The first MALDI-MS matrices and high stability GC stationary phases were also developed. Most recently, chiral RTILs have been shown to produce enantiomeric excesses from racemates and prochiral molecules via solvation effects. These solvation effects also change the luminescence behavior of chiral molecules. Representative
Publications: “Consideration on HILIC and polar organic solvent-based separations: Use of cyclodextrin and macrocyclic glycopetide stationary phases”, Wang, C., Jiang, C., Armstrong, D.W., J. Sep. Sci. 31 1980-1990 (2008). “Comprehensive two-dimensional gas chromatography
using a high-temperature phosphonium ionic liquid column”, Seeley,
J.V., Seeley, S.K., Libby, E.K., Breitbach, Z.S., Armstrong, D.W., Anal.
Bioanal. Chem. 390:323-332 (2008). “Rapid baseline separation of enantiomers and a mesoform of all-trans-astaxanthin, 13-cis-astaxanthin, adonirubin, and adoninanthin in standards and commercial supplements”, Wang, C., Armstrong, D.W., Chang, C., J. Chromatogr. A., 1194 172-177 (2008). “Influence of Chiral Ionic Liquids on the
Excited-State Properties of Naproxen Analogs”, Adhikary, R., Bose, S.,
Mukherjee, P., Thite, A., Kraus, G.A., Wijeratne, A.B., Sharma, P.S.,
Armstrong, D.W., Petrich, J.W., J. Phys. Chem. B 112 7555-7559
(2008). “Evaluating the Use of Tricationic Reagents for the Detection of Doubly Charged Anions in the Positive Mode by ESI-MS” Soukup-Hein, R.J., Remsburg, J.W., Breitbach, Z.S., Sharma, P.S., Payagala, T., Wanigasekara, E., Huang, J., Armstrong, D.W., Anal. Chem. 80 2612-2616 (2008). “Unsymmetrical Dicationic Ionic Liquids:
Manipulation of Physicochemical Properties Using Specific Structural
Architectures”, Payagala, T., Huang, J., Breitbach, Z.S., Sharma,
P.S., Armstrong, D.W. Chem. Mater. 19 5848-5850
(2007). “Enantiomeric Separations of Ruthenium(II)
Polypyridyl Complexes Using High-Performance Liquid Chromatography
(HPLC) with Cyclodextrin Chiral Stationary Phases (CSPs)”, Sun, P.,
Krishnan, A., Yadav, A., Singh, S., MacDonnell, F.M., Armstrong, D.W.
Inorg. Chem. 46 10312-10320 (2007). “Enantioseparation of Extended Metal Atom Chain
Complexes: Unique Compounds of Extraordinarily High Specific
Rotation”, Warnke, M.M., Cotton, F.A., Armstrong, D.W. Chirality
19: 179-183 (2007). “Single-Cell Detection: Test of Microbial
Contamination Using Capillary Electrophoresis”, Lantz, A.W., Bao, Y.,
Armstrong, D.W., Anal. Chem. 79 1720-1724 (2007). “Ionic Liquids in Separations”, Han, X.,
Armstrong, D.W., Acc. Chem. Res. 40 1079-1086 (2007). “A General, Positive Ion Mode ESI-MS Approach for
the Analysis of Singly Charged Inorganic and Organic Anions Using a
Dicationic Reagent”, Soukup-Hein, R.J., Remsburg, J.W., Dasgupta,
P.K., Armstrong, D.W., Anal. Chem. 79 7346-7352 (2007). “Ionic liquid-alkane association in dilute
solutions”, Berthod, A., Kozak, J.J., Anderson, J.L. Ding, J.,
Armstrong, D.W., Theor. Chem. Acc. 117 127-135 (2007). “Highly Efficient Asymmetric Direct
Stoichiometric Aldol Reactions on/in Water”, Huang, J., Zhang, X.,
Armstrong, D.W. Angew. Chem. Int. Ed. 46 9073-9077 (2007). “Theory and
Use of the Pseudophase Model in Gas-Liquid Chromatographic Enantiomeric
Separations”, Pino, V., Lantz, A. W., Anderson, J. L., Berthod, A., and
Armstrong, D.W Analytical.
Chemistry 78, 113-119 (2006). “Immobilized Ionic Liquids as High-Selectivity/High-Temperature/High-Stability Gas Chromatography Stationary Phases”, Anderson, J. and Armstrong, D.W. Analytical Chemistry 77(19), 6453-6462, (2005). “Using Geminal Dicationic Ionic Liquids as Solvents for High Temperature Organic Reactions”, Han, X. and Armstrong, D.W. Organic Letters 7(19), 4205-4208, (2005). “Chiral Ionic Liquids:
Synthesis and Applications”, Ding, J. and Armstrong, D.W. Chirality, 17(5),
281-292 (2005). “Uptake and
Enantioselective Elimination of Chlordane Compounds by Common Carp (Cyprinus
carpio, L.)”, Berthod, A, Seemamahannop, R., Maples, M., Shubhi, K., and
Armstrong, D.W. Chemosphere,
59(4), 493-500
(2005). “Pharmacokinetics and Pharmacodynamics of Theanine Enantiomers in Rats”, Desai, M.J., Gill, M.S., Hsu, W.H., and Armstrong, D.W. Chirality, 17(3), 154-162 (2005). ”Use of Chiral Ionic
Liquids as Solvents for the Enantioselective Photoisomerization of
Dibenzobicyclo[2.2.2] Octatrienes”,
Ding, J., Desikan, V., Han, X., Xiao, T.L., Ding, R., Jenks, W.S.,
and Armstrong, D.W. Org.
Lett. 7(2), 335-337 (2005). “Structure and Properties of High Stability Geminal Dicationic Ionic Liquids”, Anderson, J.L., Ding, R., Ellern, A., and Armstrong, D.W. J. Am. Chem. Soc. 127(2), 593-604 (2005). “Chiral Ionic Liquids as Stationary Phases in Gas Chromatography”, Ding. J., Welton, T. and Armstrong, D.W. Anal. Chem. 76(22), 6819-6822 (2004). “Selective Separations of Peptides with Sequence Deletions, Single Amino Acid Polymorphisms, and/or Epimeric Centers Using Macrocyclic Glycopeptide Liquid Chromatography Stationary Phases”, Zhang, B., Soukup, R., and Armstrong, D.W. J. Chroma. A 1053(1-2), 89-99 (2004). “Dynamic Solvation in Room Temperature Ionic Liquids”, Chowdhury, P.K., Halder, M., Sanders, L., Calhoun, T., Anderson, J.L., Armstrong, D.W., Song, X., and Petrich, J.W., J. Phys. Chem. B 108, 10245-10255 (2004). “Surfactant Solvation Effects and Micelle Formation in Ionic Liquids”, Anderson, J.L., Pino, V., Hagberg, E.C., Sheares, V.V., and Armstrong, D.W. Chem. Comm. (Cambridge, United Kingdom) (19), 2444-2445 (2003). “Pore Exclusion Chromatography-Inductively Coupled Plasma-Mass Spectrometry for Monitoring Elements in Bacteria: A Study on Microbial Removal of Uranium from Aqueous Solution”, Zhang, B., Li, F., Houk, R. S., and Armstrong, D.W. Anal. Chem. 75(24), 6901-6905 (2003). “Determination of the Interconversion Energy Barrier of Enantiomers by Separation Methods”, Krupcik, J., Oswald, P., Majek, P., Sandra, P., and Armstrong, D. W. J. of Chromatogr. A. 1000(1-2), 779-800 (2003). “Ionic Matrices for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Detection of DNA Oligomers”, Carda-Broch, S., Berthod, A., and Armstrong, D. W. Rap. Comm. in Mass Spec. 17(6), 553-560 (2003). “Assignment of Absolute Configuration of a Chiral Phenyl-Substituted Dihydrofuroangelicin”, Pescitelli, G., Berova, N., Xiao, T. L., Rozhkov, R. V., Larock, R. C., and Armstrong, D. W. Org. & Biomol. Chem. 1(1), 186-190 (2003). "Characterizing Ionic
Liquids On the Basis of Multiple Solvation Interactions", Anderson,
J.L., Ding, J., Welton, T., and Armstrong, D.W.
J. Amer. Chem. Soc. 124(47), 14247-14254 (2002). "Super/Subcritical
Fluid Chromatography Chiral Separations with Macrocyclic Glycopeptide
Stationary Phases", Liu, Y., Berthod, A., Mitchell, C., Xiao, T.L.,
Zhang, B., and Armstrong, D.W. J. of Chromatogr. A. 978(1-2)
185-204 (2002). "A Potent
Enantioselective Auxin: Indole-3-Succinic Acid", Armstrong, D.W.,
Liu, Y-S., He, L., Ekborg-Ott, K., Barnes, C. L., and Hammer, C.F. J. Agri. and Food Chem.
50(3), 473-476 (2002). "Determination of Cell
Viability in Single or Mixed Samples Using Capillary Electrophoresis
Laser-induced Fluorescence Microfluidic Systems", Armstrong, D.W and
He, L. Anal. Chem. 73, 4551-4557 (2001). "Ionic
Liquids as Matrices for Matrix-Assisted Laser Desorption Ionization Mass
Spectrometry", Armstrong, D.W., Zhang, L.-K., He, L., and Gross, M.
Anal. Chem. 73, 3679-3686 (2001). "Separating Microbes
in the Manner of Molecules: I. Capillary Electrokinetic Approaches",
D.W. Armstrong, G. Schulte, J.M. Schneiderheinze and D.J. Westenberg, Anal.
Chem., 71, 5465-5469 (1999). “Examination of Ionic Liquids and Their Interactions with Molecules, When Used as Stationary Phases in Gas Chromatography, Daniel W. Armstrong, Lingfeng He, and Yan-Song Liu, Anal. Chem., 71, 3873-3876 (1999).
Acknowledgment: Our work has been supported in part by the
NIH, State Department, Glaco-SmithKline, Caldwell Fund, Pfizer, and the Welch
Foundation. |
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Department of Chemistry and Biochemistry |
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