Richard (Xiyun) Guan
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The University of Texas at Arlington | |||||||||||
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Richard (Xiyun) Guan |
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Bioanalytical
and Biophysical Chemistry |
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Phone:
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E-mail: Office: 103 CRB
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B.S. China
University of Geosciences, P. R. China (1990) M.S. Chinese Academy of Geological Sciences, P. R. China (1995) Ph.D. University of Kentucky (2002) Postdoctoral Fellow:
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Honors and Awards: TORA scholarship, University of Kentucky (2000) Research interests: ·
Single molecule detection Single Molecule Detection An
aspect of my research is to use protein nano-pore technique for applications
in biotechnology at the single molecule level.
The engineered protein nano-pores
have a variety of new functional properties that could be used as a basis
for making sensors. Since the
data obtained are not obscured by the average values that are inherent in
conventional chemical and biochemical experiments, single-molecule detection
provides information about the distribution and time trajectories that would
otherwise be hidden by the statistical mean. We
are especially interested in the development of biosensors for
bio-terrorist/bio-defense chemicals, environmental pollutants, toxins, DNA
and protein molecules. Biomaterial
development for use in sensors The
design and synthesis of biomaterials is a rapidly growing interdisciplinary
area, in which the properties of molecules found in nature are mimicked or
extended to produce materials with new functional properties.
We are
interested in engineering nanotubes with a variety of novel functions, and
using the functionalized nanotubes as an alternative to current
protein-based single molecule stochastic sensing technique.
Furthermore, the development of functionalized artificial nanopore
would be another interesting research topic. Direct
and in-situ environmental monitoring and medical diagnosis One
of the greatest challenges of the development of biosensor technology is its
practical application. Most of
the current biosensor techniques still focus on detecting analytes in pure
water or low matrix samples, which restricts its usage to the laboratory
research only. We are
interested in moving biosensors out of the laboratory and into commercial
applications, for example, to develop sensing techniques that could be
employed in the analysis of environmental and biological samples, and for
the application in field detection. Representative
Publications: X. Guan, L. Q. Gu, S. Cheley, O. Braha and H. Bayley,
"Stochastic sensing of TNT with a genetically engineered pore".
ChemBioChem, in press. X. Guan, S. Ramanathan, J. P. Garris, R. S. Shetty, M.
Ensor, L. G. Bachas and S. Daunert,
"Chlorocatechol detection based on a clc operon/reporter gene
system." Anal. Chem. 2000,
72, 2423-2427. X. Guan, E. D’Angelo, W. Luo and S. Daunert,
"Whole-cell biosensing of 3-chlorocatechol in liquids and
soils." Anal.
Bioanal. Chem. 2002, 374, 841-847. S. Ramanathan, R. S. Shetty, X. Guan and S. Daunert, “Luminescence based sensing systems employing genetically engineered bacteria." In: Proceedings of the 10th. International Symposium on Bioluminescence and Chemiluminescence (A. Roda, L. Kricka, and P. Stanley, eds.), John Wiley & Sons: Chichester, England, 1999, pp 601-604.
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