|
||
|
Kevin A. Schug |
||
|
Analytical
Chemistry
Assistant Professor B.S. in Chemistry, College of William and Mary (1998) Ph.D.
in Chemistry, Virginia Polytechnic Institute and State Postdoctoral Fellow: |
|
|
|
Phone: 817-272-3541 FAX: 817-272-3808 E-mail: kschug@uta.edu Office: 358 CPB Personal Page |
||
|
AWARDS, RECOGNITION, and NOTABLE SERVICE 2010
Young Investigator Award by the Analytical Chemistry Academic Contact
Committee of Eli Lilly & Co. RESEARCH INTERESTS Soft
ionization sources, such as electrospray ionization (ESI) and
matrix-assisted laser desorption/ionization (MALDI), can be tuned to
detect and study noncovalently-bound ionic complexes by mass
spectrometry. This
capability, combined with the analytical advantages of speed and
sensitivity, allows for an efficient means to study molecular
recognition systems under a variety of condensed and gas phase
conditions. We are
specifically concerned with development of novel methods for qualitative
and quantitative analysis of molecular recognition systems by mass
spectrometry and the application of these methods to interactive systems
of current interest. Current
efforts are designed to have impact in drug discovery, chiral
separations, and elucidation of biochemical interactions. Through
the course of our work, chromatographic separations and separation
techniques play an important role.
This is especially the case in research efforts related to
the isolation and characterization of natural products.
A current source of funding is from the Texas Parks and Wildlife
Department, in an effort to elucidate and characterize the toxic
constituents produced by golden algae (Prymnesium
parvum), an organism responsible for massive fish fatalities in
Texas waterways. Selected
Publications: Raji, M.A.;
Temiyasathit, C.; Kim, S.B.; Mavromaras, G.; Ahn, J.-M.; Schug, K.A. Using Multivariate Statistical Methods to Model ESI Response
of GXG Tripeptides based on Multiple Physicochemical Parameters. Rapid
Commun. Mass Spectrom. 2009,
23, 2221-2232. Yang, J.; Zhang, Y.;
Gautam, S.; Liu, L.; Dey, J.; Chen, W.; Mason, R.P.; Serrano, C.A.;
Schug, K.A.; Tang, L. Development
of Aliphatic Biodegradable Photoluminescent Polymers. Proc.
Nat. Acad. Sci. USA 2009,
106, 10086-10091. Barnes, J.S.;
Nguyen, H.P.; Shen, S.; Schug, K.A.
General Method for Extraction of Blueberry Anthocyanins and
Identification Using High Performance Liquid Chromatography-Electrospray
Ionization-Ion Trap-Time of Flight Mass Spectrometry
J. Chromatogr. A 2009, 1216,
4728-4735. Nguyen, H.P.; Schug,
K.A. The Advantages of
ESI-MS Detection in Conjunction with HILIC Mode Separations:
Fundamentals and Applications.
J. Sep. Sci. 2008, 31, 1465-1480. Fryčák, P.;
Schug, K.A. Dynamic
Titration: Determination of Dissociation Constants for Noncovalent
Complexes in Multiplexed Format Using HPLC-ESI-MS. (Accelerated Article)
Anal. Chem. 2008, 80, 1385-1393. Schug, K.A.
Solution Phase Enantioselective Recognition and Discrimination by
Electrospray Ionization Mass Spectrometry:
State-of-the-Art, Methods, and an Eye towards Increased
Throughput Measurements. Combinatorial
Chemistry & High Throughput Screening 2007,
10, 301-316. Schug, K.A.; Lindner, W. Noncovalent
Binding between Guanidinium and Anionic Groups:
Focus on Biological- and Synthetic-Based Arginine/Guanidinium
Interactions with Phosph[on]ate and Sulf[on]ate Residues.
Chem. Rev. 2005, 105, 67-113.
|
||
|
Department of Chemistry and Biochemistry |
||