Functional Applied Biomaterials Laboratory

The Functional Applied Biomaterials Lab develops various biomaterials to solve relevant clinical problems. Our main areas of interest are:

  • Biodegradable elastic polymers and functional/smart biomaterials development
  • Stem cell engineering
  • Tissue repair and regeneration
  • Medical devices and drug delivery

Current Research

  • Functional elastic biomaterials for cardiovascular tissue repair and regeneration
  • 3D bio-printable biomaterials for tissue regeneration
  • Decellularized biologic matrix for tissue repair and protection

Personnel

Yi Hong, Ph.D., Lab Director

Selected Publications

  • Sanjay Anand, Vidhi Desai, Nesreen Alsmadi, Aswini Kanneganti, Dianna Nguyen, Martin Tran, Lokesh Patil, Srikanth Vasudevan, Cancan Xu, Yi Hong, Jonathan Cheng, Edward W. Keefer, Mario Romero-Ortega. Asymmetric sensory-motor regeneration of transected peripheral nerves using molecular guidance cues. Scientific Reports, 2017, 7:14323.
  • Nikhil Pandey, Amirhossein Hakamivala, Cancan Xu, Prashant Hariharan, Boris Radionov, Zhong Huang, Jun Liao, Philippe Zimmern, Kytai Nguyen*, Yi Hong*. Biodegradable nanoparticles enhanced adhesiveness of mussel-like hydrogels at tissue interface. Advanced Healthcare Materials, 2017, Accepted.
  • Taylor Dorsey, Alexander Grath, Cancan Xu, Yi Hong, Guohao Dai. Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications. Journal of Visualized Experiments 2017, 127:e55873.
  • Yihui Huang, Jun Zhou, Amirhossein Hakamivala, Jinglei Wu, Yi Hong, Joseph Borrelli, Liping Tang. An optical probe for detecting chondrocyte apoptosis in response to mechanical injury. Scientific Reports 2017, 7: 10906.
  • Taylor Dorsey, Alexander Grath, Annling Wang, Cancan Xu, Yi Hong, Guohao Dai. Evaluation of photochemistry reaction kinetics to pattern bioactive proteins on hydrogels for biological applications. Bioactive Materials 2017, Online release.
  • Bingbing Cheng, Venugopal Bandi, Francis D'souza, Kytai T. Nguyen, Yi Hong, Liping Tang, Baohong Yuan. The mechanisms and biomedical applications of an NIR BODIPY-based switchable fluorescent probe. International Journal of Molecular Science, 2017, 18(2): 384.
  • Jayanth Kandukuri, Shuai Yu, Bingbing Cheng, Venugopal Bandi, Francis D'souza, Kytai T. Nguyen, Yi Hong, Baohong Yuan. A dual-modality system for both multi-color ultrasound-switchable fluorescence and ultrasound imaging. International Journal of Molecular Science, 2017, 18 (2): 323.
  • Jinglei Wu, Priya Ravikumar, Kytai Nguyen, Connie Hsia*, Yi Hong*. Lung protection by inhalation of exogenous solubilized extracellular matrix. PLoS One, 2017: e0171165.
  • Cancan Xu, Yihui Huang, Liping Tang, Yi Hong. Low initial modulus biodegradable polyurethane elastomers for soft tissue regeneration. ACS Applied Materials & Interfaces 2017, 9(3):2169-2180.
  • Keisuke Takanari, Ryotaro Hashizume, Yi Hong, Nicholas J. Amoroso, Tomo Yoshizumi, Burhan Gharaibeh, Osamu Yoshida, Kazuhiro Nonaka, Hideyoshi Sato, Johnny Huard, William R. Wagner. Skeletal muscle derived stem cells microintegrated into a biodegradable elastomer for reconstruction of the abdominal wall. Biomaterials 2017, 113:31-41.
  • Shuai Yu, Bingbing Cheng, Tingfeng Yao, Cancan Xu, Kytai Nguyen, Yi Hong, Baohong Yuan. New generation ICG-based contrast agents for ultrasound-switchable fluorescence imaging. Scientific Reports 2016, 6:35942.
  • Cancan Xu, Yihui Huang, Gerardo Yepez, Zi Wei, Fuqiang Liu, Alejandro Bugarin, Liping Tang, Yi Hong. Development of dopant-free conductive bioelastomers. Scientific Reports 2016, 6: 34451.
  • Bingbing Chen, Venugopal Bandi, Ming-Yuan Wei, Yanbo Pei, Francis D’Souza, Kytai T. Nguyen, Yi Hong, Baohong Yuan. High-resolution fluorescence imaging in centimeter-deep tissue phantoms with high signal-to-noise ratio and picomole sensitivity via novel contrast agents. PLoS One 2016, 11(11): e0165963.
  • Jinglei Wu, Yi Hong. Enhancing cell infiltration of electrospun scaffolds for tissue engineering. Bioactive Materials 2016, 1(1):56-64.
  • Cancan Xu, Gerardo Yepez, Zi Wei, Fuqiang Liu, Alejandro Bugarin, Yi Hong. Synthesis and characterization of conductive, biodegradable, elastomeric polyurethanes for biomedical applications. Journal of Biomedical Materials Research Part A 2016, 104 (9): 2305-2314.
  • Keisuke Takanari*, Yi Hong*, Ryotaro Hashizume, Alexander Huber, Nicholas J. Amoroso, Antonio D’Amore, Stephen F. Badylak, William R. Wagner. Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomer. Journal of Tissue Engineering and Regenerative Medicine 2016, 10(9):748-761. (Co- first author)
  • Bo Wang, Sourav S. Patnaik, Bryn Brazile, J. Ryan Butler, Andrew Claude, Ge Zhang, Jianjun Guan, Yi Hong*, Jun Liao*. Establishing early functional perfusion and structure in tissue engineered cardiac constructs. Critical Review in Biomedical Engineering 2015, 43(5-6): 455-471. Co-corresponding author.
  • Cancan Xu, Yihui Huang, Jinglei Wu, Liping Tang, b. Triggerable degradation of polyurethanes for tissue engineering applications. ACS Applied Materials & Interfaces 2015, 7 (36): 20377–20388.
  • Guifang Gao, Arndt F. Schilling, Karen Hubbell, Tomo Yonezawa, Danh Truong, Yi Hong, Guohao Dai, Xiaofeng Cui. Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA. Biotechnology Letter 2015, 37 (11): 2349-2355.
  • Syed Dawar Sajjad, Dong Liu, Zi Wei, Shambhavi Sakri, Yi Shen, Yi Hong, Fuqiang Liu. Guanidinium based blend anion exchange membranes for direct methanol alkaline fuel cells. Journal of Power Sources. 2015, 300:95-103.
  • Megan E. Jeffords, Jinglei Wu, Mickey Shah, Yi Hong*, Ge Zhang*. Tailoring material properties of cardiac matrix hydrogels to induce endothelial differentiation of human mesenchymal stem cells. ACS Applied Materials & Interfaces 2015. 7(20): 11053-61. Co-corresponding author.
  • Christopher M Hobson, Nicholas J Amoroso, Rouzbeh Amini, Ethan Ungchusri, Yi Hong, Antonio D'Amore, Michael S Sacks, William R Wagner. Fabrication of elastomeric scaffolds with curvilinear fibrous structures for heart valve leaflet engineering. Journal of Biomedical Materials Research Part A 2015, 103(9): 3101-6.
  • Jinglei Wu, Qing Ding, Yezhou Wang, Yihui Huang, Hong Weng, Liping Tang, Yi Hong. An injectable extracellular matrix derived hydrogels for meniscus repair and regeneration. Acta Biomaterialia 2015, 16:49-59.
  • Sang-Ho Ye*, Yi Hong*, Hirokazu Sakaguchi, Venkat Shankarraman, William R. Wagner. Non-thrombogenic, biodegradable elastomeric polyurethanes with variable sulfobetaine content. ACS Applied Materials & Interfaces 2014, 6(24): 22796–22806. Co-first author.
  • Primana Punnakitikashem, Danh Truong, Jyothi U. Menon, Kytai T. Nguyen, Yi Hong. Electrospun biodegradable elastic polyurethane fibers with dipyridamole release as small diameter vascular grafts. Acta Biomaterialia 2014, 10 (11):4618-4628.
  • Huili Fu*, Yi Hong*, Steve R. Little, William R. Wagner. Collagenase-labile polyurethane urea synthesis and processing into hollow fiber membranes. Biomacromolecules 2014, 15 (8):2924–2932. Co-first author.
  • Jessica Perkins, Yi Hong, Sang-Ho Ye, William R. Wagner, Salil Desai. Direct writing of bio-functional coatings for cardiovascular applications. Journal of Biomedical Materials Research Part A, 2014, 102(12):4290-4300.
  • Syed D. Sajjad, Yi Hong, Fuqiang Liu. Synthesis of guanidinium based anion exchange membranes and their stability assessment. Polymer for Advanced Technologies, 2014, 25:108-116.
  • Bingbing Cheng, Ming-Yuan Wei, Yuan Liu, Harish Pitta, Zhiwei Xie, Yi Hong, Kytai T. Nguyen, Baohong Yuan, Development of ultrasound-switchable fluorescence imaging contrast agents based on thermosensitive polymers and nanoparticles. The IEEE Journal of Selected Topics in Quantum Electronics 2014, 20 (3):6801214.
  • Jiao Yu, Keisuke Takanari, Yi Hong, Keewon Lee, Nicholas Amoroso, Yadong Wang, William Wagner, Kang Kim. Non-invasive characterization of polyurethane-based tissue constructs on rat abdominal repair model using high frequency ultrasound elasticity imaging. Biomaterials 2013, 34(11):2701-2709.
  • Ye SH, Jang YS, Yun Y, Shankarraman V, Woolley JR, Hong Y, Gamble LJ, Ishihara K, Wagner WR. Surface modification of a biodegradable magnesium alloy with phosphorylcholine (PC) and sulfobetaine (SB) functional macromolecules for reduced thrombogenicity and acute corrosion resistance. Langmuir 2013, 29(26):8320-8327.
  • Ryotaro Hashizume, Yi Hong, Keisuke Takanari, Kazuro L. Fujimoto, Kimimasa Tobita, William R. Wagner. The effect of polymer degradation time on functional outcomes of temporary elastic patch support in ischemic cardiomyopathy. Biomaterials 2013, 34(30):7353-7363.
  • Yi Hong, Sang-Ho Ye, Anca L. Pelinescu, William R. Wagner. Synthesis, characterization and paclitaxel release from a biodegradable, elastomeric, poly(ester urethane)urea bearing phosphorylcholine groups for reduced thrombogenicity. Biomacromolecules 2012, 13(11):3686-3694.
  • Ryotaro Hashizume, Kazuro L. Fujimoto, Yi Hong, Jianjun Guan, Catalin Toma, Kimimasa Tobita, William R. Wagner. Biodegradable elastic patch-plasty ameliorates left ventricular adverse remodeling after ischemia-reperfusion injury: A preclinical study of a porous polyurethane material in a porcine model. J Thorac Cardiovasc Surg 2012.
  • Amoroso NJ, D'Amore A, Hong Y, Rivera CP, Sacks MS, Wagner WR.Microstructural manipulation of electrospun scaffolds for specific bending stiffness for heart valve tissue engineering. Acta Biomater 2012, 8:4268-4277.
  • Hong Y, Takanari K, Amoroso NJ, Hashizume R, Brennan-Pierce EP, Freund JM, Badylak SF, Wagner WR. An elastomeric patch electrospun from a blended solution of dermal extracellular matrix and biodegradable polyurethane for rat abdominal wall repair.Tissue Eng Part C Methods 2012,18(2):122-132.
  • He W, Nieponice A, Hong Y, Wagner WR, Vorp DA. Rapid engineered vascular grafts from smooth muscle cells. Cardiovasc Eng Technol 2011,2:149-159.
  • Ma Z, Hong Y, Nelson DM, Pichamuthu JE, Leeson CE, Wagner WR. Biodegradable polyurethane ureas with variable polyester or polycarbonate soft segments: effects of crystallinity, molecular weight, and composition on mechanical properties.Biomacromolecules 2011,12(9):3265-3274.
  • Amoroso NJ, D'Amore A, Hong Y, Wagner WR, Sacks MS. Elastomeric electrospun polyurethane scaffolds: the interrelationship between fabrication conditions, fiber topology, and mechanical properties. Adv Mater 2011,23(1):106-111.
  • Soletti L, Nieponice A, Hong Y, Ye SH, Stankus JJ, Wagner WR, Vorp DA. In vivo performance of a phospholipid-coated bioerodable elastomeric graft for small-diameter vascular applications. J Biomed Mater Res A 2011,96(2):436-448.
  • Baraniak PR, Nelson DM, Leeson CE, Katakam AK, Friz JL, Cress DE, Hong Y, Guan J, Wagner WR. Spatial control of gene expression within a scaffold by localized inducer release. Biomaterials 2011,32(11):3062-3071.
  • Hong Y, Huber A, Takanari K, Amoroso NJ, Hashizume R, Badylak SF, Wagner WR. Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold. Biomaterials 2011,32(13):3387-3394.
  • He W, Nieponice A, Soletti L, Hong Y, Gharaibeh B, Crisan M, Usas A, Peault B, Huard J, Wagner WR, Vorp DA. Pericyte-based human tissue engineered vascular grafts. Biomaterials 2010,31(32):8235-8244.
  • Soletti L, Hong Y, Guan J, Stankus JJ, El-Kurdi MS, Wagner WR, Vorp DA. A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts. Acta Biomater 2010,6(1):110-122.
  • Nieponice A, Soletti L, Guan J, Hong Y, Gharaibeh B, Maul TM, Huard J, Wagner WR, Vorp DA. In vivo assessment of a tissue-engineered vascular graft combining a biodegradable elastomeric scaffold and muscle-derived stem cells in a rat model. Tissue Eng Part A 2010,16(4):1215-1223.
  • Hashizume R, Fujimoto KL, Hong Y, Amoroso NJ, Tobita K, Miki T, Keller BB, Sacks MS, Wagner WR. Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold. Biomaterials 2010,31(12):3253-3265.
  • Hong Y, Guan J, Fujimoto KL, Hashizume R, Pelinescu AL, Wagner WR. Tailoring the degradation kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds. Biomaterials 2010, 31(15):4249-4258.
  • Ma Z, Nelson DM, Hong Y, Wagner WR. Thermally responsive injectable hydrogel incorporating methacrylate-polylactide for hydrolytic lability. Biomacromolecules 2010,11(7):1873-1881.
  • Hong Y, Ye SH, Nieponice A, Soletti L, Vorp DA, Wagner WR. A small diameter, fibrous vascular conduit generated from a poly(ester urethane)urea and phospholipid polymer blend. Biomaterials 2009,30(13):2457-2467.
  • Hong Y, Gong Y, Gao C, Shen J. Collagen-coated polylactide microcarriers/chitosan hydrogel composite: injectable scaffold for cartilage regeneration. J Biomed Mater Res A 2008,85(3):628-637
  • Hong Y, Fujimoto K, Hashizume R, Guan J, Stankus JJ, Tobita K, Wagner WR. Generating elastic, biodegradable polyurethane/poly(lactide-co-glycolide) fibrous sheets with controlled antibiotic release via two-stream electrospinning. Biomacromolecules 2008,9(4):1200-1207.
  • Guan J, Hong Y, Ma Z, Wagner WR. Protein-reactive, thermoresponsive copolymers with high flexibility and biodegradability. Biomacromolecules 2008,9(4):1283-1292.
  • El-Kurdi MS, Hong Y, Stankus JJ, Soletti L, Wagner WR, Vorp DA. Transient elastic support for vein grafts using a constricting microfibrillar polymer wrap.Biomaterials 2008,29(22):3213-3220.
  • Stella JA, Liao J, Hong Y, David Merryman W, Wagner WR, Sacks MS. Tissue-to-cellular level deformation coupling in cell micro-integrated elastomeric scaffolds. Biomaterials 2008, 29(22):3228-3236.
  • Stankus JJ, Soletti L, Fujimoto K, Hong Y, Vorp DA, Wagner WR. Fabrication of cell microintegrated blood vessel constructs through electrohydrodynamic atomization. Biomaterials 2007, 28(17):2738-46.
  • Hong Y, Song H, Gong Y, Mao Z, Gao C, Shen J. Covalently crosslinked chitosan hydrogel: properties of in vitro degradation and chondrocyte encapsulation. Acta Biomater 2007,3(1):23-31.
  • Hong Y, Mao Z, Wang H, Gao C, Shen J. Covalently crosslinked chitosan hydrogel formed at neutral pH and body temperature. J Biomed Mater Res A 2006,79(4):913-922.
  • Hong Y, Gao CY, Shi YC, Shen JC. Preparation of porous polylactide microspheres via emulsion-solvent evaporation based on solution induced phase separation. Polym Adv Technol 2005,16:622-627.
  • Hong Y, Gao C, Xie Y, Gong Y, Shen J. Collagen-coated polylactide microspheres as chondrocyte microcarriers. Biomaterials 2005,26(32):6305-6313.
  • Gao C, Hu X, Hong Y, Guan J, Shen J. Photografting of poly(hydroxylethyl acrylate) onto porous polyurethane scaffolds to improve their endothelial cell compatibility. J Biomater Sci Polym Ed 2003,14(9):937-950.
  • Hong Y, Gao CY, Guan JJ, Shen JC. Influence of quaternized polyurethane membrane surfaces on human endothelial cell attachment and growth. J Bioact Compat Polym 2003, 18:191-206