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The University of Texas at ArlingtonThe University of Texas at Arlington


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CHEMISTRY & BIOCHEMISTRY

Daniel W. Armstrong

Daniel W. Armstrong

Professor
Robert A. Welch Distinguished Professor


Office: 303 Chemistry Research Building (CRB)
Email: sec4dwa@uta.edu
Phone: 817-272-0632
FAX: 817-272-0619
Mentis Profile

CV DWA

Education:
B.S.
Washington and Lee University, 1972
M.S. Texas A&M University, 1974
Ph.D. Texas A&M University, 1977


Research

Chiral Molecular Recognition, Novel Ionic Liquids (synthesis and use), Separations, Mass Spectrometry, Bioanalytical Chemistry, Pharmaceutical Analysis, Environmental Analysis, Microbiological Signaling and Analysis. 

Armstrong Research1Armstrong Research2

Biography

Daniel W. Armstrong is the R. A. Welch Distinguished Professor at the University of Texas at Arlington. He also serves as AZYP’s President, CEO and founder. He has over 35 years of experience in the field of chromatographic enantiomeric separations and chromatography hyphenated with mass spectrometry, vacuum UV and other detection systems along with over 730 publications, including 35 book chapters, one book “Use of ordered Media in Chemical Separations”, and 35 patents. His work has been cited ~ 46,200 times and he has an h-index of 109. He has been named by the Scientific Citation Index as one of the world’s most highly cited scientist, as well as given over 560 invited seminars and colloquia worldwide. Considered the “Father” of micelle and cyclodextrin based separations, he elucidated the first chiral recognition mechanism by cyclodextrins, was the first to develop macrocyclic antibiotics as chiral selectors, and is one of the world’s leading authorities on the theory, mechanism and use of enantioselective molecular interactions. Professor Armstrong has likely synthesized more new ionic liquids (ILs) than anyone worldwide and has used these for separations and mass spectrometry. He is an expert on ILs of high thermal stability and he devised the most highly cited characterization criteria for all ILs. Many of these species have been commercialized. Over 30 different HPLC and GC columns that were originally developed in his laboratories have been commercialized and/or copied worldwide. His work and columns were in part responsible for the chromatography and electrophoresis-lead revolution in chiral separations over the last three decades. His work, in part, provided the impetus for the FDA to pass its 1992 guidelines regarding the separation of stereoisomeric drugs. Currently, the columns, chiral selectors and techniques he developed dominate the world of analytical enantiomeric separations. His experience in the field of producing new chiral stationary phases is unmatched worldwide. Additionally, he has a great deal of experience in startup companies as he helped found Advanced Separations Technologies (AXTEC), a company that produced and sold cyclodextrin and macrocyclic antibiotics based chiral selectors and chiral stationary phases. Later, ASTEC was bought by Supelco/Sigma Aldrich, (the largest specialty chemical company in the United States) approximately 11 years ago. More recently, he started the company AZYP, LLC which manufactures chromatography columns, does contract research and develops new analytical methodologies. His collaboration and leadership on this Phase II SBIR is integral to its success.

Publications

“The Roles of N-Methyl-D-Aspartate Receptors and D-Amino Acids in Cancer Cell Viability” Du, S.; Sung, Y.S.; Wey,M.; Wang, Y.; Alatrash, N.; Bertod, A.; MacDonnell, F.; Armstrong, D.W.; Mol. Biol. Rep. 47, 9, 6749-6758 (2020).

 

“Enhancing Supercriticial Fluid Chromatographic Efficiency: Predicting effects of small aqueous addititves” Khvalbota, L.; Roy, D.; Wahab, M.F.; Firooz, S.K.; Machynakova, A.; Spanik, I.; Armstrong, D.W.  Anal. Chim. Acta 1120, 2927-2937 (2020).

 

“Enantiomeric Separation of Quorum Sensing Autoinducer Homoserine Lactones Using GC-MS and LC-MS”, Readel, E., Portillo, A., Talebi, M., Armstrong, D.W., Anal. Bioanal. Chem.  412, 2927-2937 (2020).

 

“Improving Peak Capacities Over 100 in Less Than 60 Seconds: Operating Above Normal Peak Capacity Limits with Signal Processing”, Hellinghausen, G., Wahab, M.F., Armstrong, D.W., Anal. Bioanal. Chem., 412, 1925-1932 (2020).

 

“Replacing Methanol with Azeotropic Ethanol as the Co-Solvent for Improved Chiral Separations with Supercritical Fluid Chromatography (SFC)”, Roy, D., Wahab, M.F., Talebi, M., Armstrong, D.W., Green Chem., 22,1249- 1257 (2020).

 

“Complete Identification of All 20 Relevant Epimeric Peptides in B-Amyloid: a New HPLC-MS Based Analytical Strategy for Alzheimer’s Research”, Du, S., Readel, E.R., Wey, M., and Armstrong, D.W., Chem Commun., 56, 1537-1540 (2020).

 

“A Gas Chromatography-Molecular Rotational Resonance Spectroscopy Based System of Singular Specificity”, Armstrong, D.W., Talebi, M., Thakur, N., Wahab, M.F., Mikkhoini, A.V., Muckle, M.T., and Neill, J.L., Angew. Chemie Int. Ed., 59, 192-196 (2020).

 

“Enantiomeric Impurities in Chiral Catalysts, Auxiliaries, and Synthons used in Enantioselective Syntheses. Part 5”, Thakur, N., Patil, R.A., Talebi, M., Readel, E.R., and Armstrong, D.W., Chirality, 31, 688-699 (2019).

 

“Synthetic Aluminosilicate Based Geopolymers-Second Generation Geopolymer HPLC Stationary Phases”, Thakur, N., Wahab, M.F., Khanal, D.D., and Armstrong, D.W., Anal. Chim. Acta, 1081, 209-217 (2019).

 

“Selective Depletion of Chiral 4‑Hydroxypraziquantel Metabolites in Three Types of Aquaculture Fish by LC-MS/MS”, Zhang, Y., He, L., Xuezhi, L., Wang, Y. Jingmeng, X., Lee, J.T., and Armstrong, D.W., J. of Agri. & Food Chem., 67, 4098-4104 (2019).

 

“Altered Profiles and Metabolism of L- and D Amino Acids in Cultured Human Breast Cancer Cells vs. Non-Tumorigenic Human Breast Epithelial Cells”, Du, S., Wang, Y. Alatrash, N., Weatherly, C.A., Roy, D. MacDonnell. F.M. and Armstrong, D.W., J. Pharm. Biomed. Anal., 164, 421-429 (2019).

 

“Improving Visualization of Trace Components for Quantification Using a Power Law Based Integration Approach”, Hellinghausen, G., Wahab, M.F., and Armstrong, D.W., J. Chromatogr. A, 1574, 1-8 (2018).

 

“Geopolymers as a New Class of High pH Stable Support with Different Chromotographic Selectivity”, Wimalasinghe, R., Weatherly, C., Wahab, M.F., Thakur, N., and Armstrong, D.W., Anal. Chem., 90, 8139-8146 (2018).

 

“Dicationic Ionic Liquid Thermal Decompostion Pathways”, Patil, R., Talebi, M., Berthod, A., and Armstrong, D.W., Anal. Bioanal. Chem., 410, 4645-4655 (2018).

 

“Variations of L- and D- Amino Acid Levels in the Brain of Wild-Type and Mutant Mice Lacking D-Amino Acid Oxidase Activity”, Du, S., Wang, Y., Weatherly, C.A., Holden, K., and Armstrong D.W., Anal. Bioanal. Chem., 410, 2971-2979, (2018).

 

“Effective Methodologies for Enantiomeric Seperation of 150 Phamacology and Toxicology related 1°, 2°, and 3° amines with Core-Shell Chiral Stationary Phases” Hellinghausen, G., Roy, D., Lee, J.T., Wang, Y., Weatherly, C.A., Lopez, D., Nguyen, K. Armstrong, J.D., and Armstrong D.W., J. Pharm. Biomed. Anal., 155, 70-81(2018)

 

“Separations at Sensor Speeds”, Patel, D.C., Wahab, M.F., O’Haver, T.C. and Armstrong, D.W., Anal. Chem. 90, 3349-3356 (2018).

 

“A Comprehesive Methodology for the Chiral Separation of 40 Tobacco Alkaloids and their Carcinagenic E/Z-(R,S)-Tobacco-Specific Nitrosamine Metabolites”, Hellinghausen, G., Diapayan, R., Wang, Y., Lee, J.T., Lopez, D., Weatherly, C. and  Armstrong, D.W., Talanta, 181, 132-141 (2018).

 

”Determination of the Interconversion Energy Barrier of Three Novel Pentahelicene Derivative Enantiomers by Dynamic High Resolution Liquid Chromatography”, Majek, P., Krupcik, J., Breitbach, Z.S., Dissanayake, M.K., Kroll, P., Ruch, A.A., Slaughter, L.M. and Armstrong, D.W., J. Chrom. B. 1051, 60-67 (2017).

 

“Instrumental Idiosyncrasies Affecting the Performance of Ultrafast Chiral and Achiral Sub/Supercritical Fluid Chromatography”, Barhate, C.L., Wahab, M.F., Tognarelli, D.J., Berger, T.A. and Armstrong, D.W., Anal. Chem. 88, 8664-8672 (2016).

Awards

Dr. Armstrong has received the Eastern Analytical Award for Chromatography (1990), Great Britain's Martin Medal (1991) (named for Nobel laureate A.P.J. Martin), and the Isco Award for contributions to instrumentation for biochemical separations(1991), the Presidential Award for Research and Creativity (1993), the ACS Midwest Award in Chemistry (1993), the Perkin Elmer Award for Capillary Electrophoresis (1994),  The R&D 100 Award for Inventions leading to a better world (1995), and was named a Fellow of the American Association of Pharmaceutical Scientists (1995).  He was given the Benedetti-Pichler Award (1996) in microchemistry; the Karen Morehouse Award (1997), the ACS Helen M. Free Award (1998). In 1999 Dr. Armstrong was given the ACS Award in Chromatography as well as the Distinguish Scholar Award from Hope College/Park Davis.  He received the Chicago Area Chromatography Discussion Group (CCDG) Merit Award (2001), was awarded the Weber Medal (2001), and was made an honorary member of the Slovacae Pharmaceutical Society for his contributions to the Pharmaceutical Sciences (2001).  Dr. Armstrong received the Spencer Award for Agriculture and Food Chemistry(2002), the Chirality Medal (2003) and the Zuffa medal for Pharmaceutical Chemistry (2004.)  Dr. Armstrong was the 2005 Dal Nogre Award winner presented at the Pittsburgh Conference and was awarded the Medal of the Slovak Medical Society (2005). He has served as Separations Associate Editor for Analytical Chemistry and was the Editor of the international journal Chirality, a Section Editor for Amino Acids, and a member of the Editorial Board of over 20 other journals.  Dr. Armstrong was admitted as a Fellow of The Royal Society of Chemistry (2009) and named American Chemical Society Fellow (2013).  He received the UTA Distinguished Record of Research or Creative Activity (2012) and was elected as Fellow of the National Academy of Inventers (2014).  During 2014 Dr. Armstrong received the ACS Award for Separation Science & Technology, the M.J.E. Golay Award, and the UT Arlington Distinguished Scholars Award.  Dr. Armstrong was named to the Analytical Scientist’s 2015 Power List Top 10 and the Wilfred T. Doherty Research & Service Award – DFW Section of American Chemical Society (2015). Dr. Armstrong was listed as Analytical Scientist 2017 in Separations Powerlist Top 10. During 2018 Dr. Armstrong received Dow Chemical WesTEC Award for “Distinguished Leader in Science and Technology”, a  Doctor Honoris Causa Degree from Slovak University of Technology and the UTA Excellence in Doctoral Mentoring Award.  Dr. Armstrong among the top 10 Analytical Scientist in the World for 2019 and received the LCGC Lifetime Achievement Award in 2020.

 

Dr. Armstrong is a member of the American Chemical Society, American Association for the Advancement of Science, Smithsonian Associate and Sigma XI.  His current research involves chiral recognition, specific separation and detection of enantiomers, cyclodextrin chemistry, investigation of biologically active molecules, macrocyclic antibiotics, and high efficiency microbial analysis, and use of room temperature ionic liquids in chemical analysis and separations. He also has interests in a variety of other areas from oceanography to gemstone analysis. He originated and broadcast the NPR (National Public Radio) show, “We’re Science” that was broadcast on ~140 stations and the Armed Forces Network.


(List does not include named lectureships, visiting professorships, lecture or poster awards, etc.)

Professorial (Distinguished ) Chairs:

1989 Curator’s Professorship (U. Missouri-Rolla)

2000 Caldwell Professorship (Iowa State University)

2006 Robert A. Welch Professorship (University of Texas at Arlington)

Editorial Recognitions

Separations Associate Editor for Analytical Chemistry.

Former Editor of Chirality.

Section Editor for Amino Acids.

Member of the Editorial Board of

Journal of Pharmaceutical & Biomedical Analysis

Amino Acids Journal

The Journal of Chromatography

The Journal of Liquid Chromatography

The Journal of Planar Chromatography

Journal of Inclusion

Phenomena, Separation Science and Technology

Chromatographia

Member of the Instrumentation Board for Analytical Chemistry, 1990.

Member of the Scientific Advisory Board for Analytical Chemistry, 1996-98.

1999 Editorial Advisory Board of Chromatographia,

2001 Editorial Advisory Board for Electrophoresis, Chromatographia

2008 Editorial Board for Scientia Chromatographia