Office: 202 Chemistry Research Building (CRB)
Phone: 817 272 5245
B.S. University of Richmond, 1999
Ph.D. University of Virginia, 2006 (Timothy L. Macdonald)
Post Doctorate: Columbia University, 2006-2008 (Ronald Breslow)
Bioorganic Chemistry – Medicinal Chemistry – Organic Synthesis:
Bioinspired Organocatalysis: Oxidation and Reduction Catalysts
Anti-Infective Small Molecule Development
Investigation of Bacterial Enzyme Function
Design and Synthesis of Functional Organic Molecules
Frank W. Foss Jr. joined the University of Texas at Arlington in September of 2008. A native of Massachusetts, he completed a Bachelors of Science in chemistry at the University of Richmond. He earned his Doctorate in organic and medicinal chemistry under the supervision of Timothy L. Macdonald from the University of Virginia. His dissertation on the Synthesis of Biologically-Stable Phospholipids is entitled “Synthesis of Bioavailable Sphingosine-1-Phosphate Receptor Ligands: Structure-Activity-Relationships, Enzymatic Regulation, and Immunosuppression.” After his graduate work, he undertook a Post-Doctoral Research position with Ronald Breslow, at Columbia University in the City of New York, to study natural catalysis by designing artificial enzymes. In addition to this biomimetic research, Frank was involved in collaborative efforts in the area of molecular electronics through the NSF-funded Nanoscale Science and Engineering Center. Both fields challenge organic chemists to understand the fundamental properties of chemical structures in biology and material sciences in order to tailor new materials with desirable functions.
The Foss Laboratory at UT Arlington is currently involved in designing biomimetic redox catalysts that utilize sustainable oxidants, such as O2 or H2O2, to perform these important synthetic transformations. The laboratory also investigates a range of enzymes, through their interaction with small molecules, to understand their function and potential as tractable targets for new drug development. Finally, numerous collaborations exist that allow the laboratory to design and synthesize natural and non-natural biomolecules for a range of purposes, from medicinal to biomaterial.
E. Bainglass, B. J. P. Jones, F. W. Foss, Jr., M. N. Huda, and D. R. Nygren “Mobility and clustering of barium ions and dications in high-pressure xenon gas” Phys. Rev. A 97, 062509 –Submitted on 30 Mar 2018 (v1), Published 21 June 2018 last revised 10 Aug 2018 (this version, v2) (DOI: 10.1103/PhysRevA.97.062509)
Allegra Leghissa, Zacariah L. Hildenbrand, Frank W. Foss Jr., Kevin A. Schug “Determination of the metabolites of Δ9-tetrahydrocannabinol in urine and plasma using multiple reaction monitoring gas chromatography–triple quadrupole–mass spectrometry” Separation Science Plus, 2018, 1, 43-47 (DOI: 10.1002/sscp.201700006)
Allegra Leghissa, Zacariah L. Hildenbrand, Frank W. Foss Jr., Kevin A. Schug "Determination of cannabinoids from a surrogate hops matrix using multiple reaction monitoring gas chromatography–triple quadrupole–mass spectrometry" Journal of Separation Science, 2017, MS# jssc.201700946.R1, Accepted 10/25/2017
William Morrow, Sinjinee Sardar, Pawan Thapa, Mohammad S. Hossain, Frank W. Foss Jr., Brad Pierce “Thiol dioxygenase turnover yields benzothiazole products from 2-mercaptoaniline and O2-dependent oxidation of primary alcohols” Archives of Biochemistry and Biophysics 2017, 631, 66-74 (DOI: 10.1016/j.abb.2017.08.013)
Attila Kormányos, Mohammad S. Hossain, Frank W. Foss Jr., Csaba Janáky, Krishnan Rajeshwar “Electrocatalytic Behavior of Freely-Diffusing and Immobilized Synthetic Flavins in Aqueous Media” Catalysis Science and Technology 2016, 6, 8441-8448 (DOI: 10.1039/C6CY02051H)
Joshua K. Crowell, Sinjinee Sardar, Mohammad S. Hossain, Frank W. Foss Jr. and Brad S. Pierce "Non-chemical proton-dependent steps prior to O2-activaiton limit Azotobacter vinelandii 3-mercaptopropionic acid dioxygenase (MDO) catalysis" Archives of Biochemistry and Biophysics. 2016 Ahead of Print (DOI: 10.1016/j.abb.2016.06.009)
Pandiri, Manjula; Hossain, Mohammad S.; Foss, Jr., Frank W.; Rajeshwar, Krishnan; Paz, Yaron “Enhanced photocatalytic activity of a self-stabilized synthetic flavin anchored on a TIO2 surface” Physical Chemistry Chemical Physics 2016, 18, 18575-18583. (DOI: 10.1039/C6CP02060G)
Attila Kormányos, Mohammad S. Hossain, Ghazaleh Ghadimkhani, Joe J. Johnson, Csaba Janáky, Norma R. de Tacconi, Frank W. Foss Jr, Yaron Paz and Krishnan Rajeshwar "Flavin Derivatives with Tailored Redox Properties: Synthesis, Characterization and Electrochemical Behavior" Chemistry - A European Journal 2016, 22, 9209-9217 (DOI: 10.1002/chem.201600207)
Rochkind, Malka; Pandiri, Manjula; Hossain, Mohammad; Foss, Jr. Frank W.; Rajeshwar, Krishnan; Paz, Yaron "Enhancement of Photoinduced Visible Light Degradation of Salicylic Acid by Covalently-Attached Synthetic Flavins on BiOCl Semiconductor Particle Surfaces" Journal of Physical Chemistry, C. - Special Issue for Kohei Uosaki Ahead of Print (DOI: 10.1021/acs.jpcc.5b12768)
Ebenezer Joseph, Cuong Quang Le, Toan Nguyen, MercyOyugi, Mohammad Shawkat Hossain, Frank W. Foss Jr. and Kayunta Johnson-Winters “Evidence of negative cooperativity and half-site reactivity within an F420-dependent enzyme: A kinetic analysis of F420H2:NADP+ oxidoreductase” Biochemistry 2016, 55, 1082-1090 (DOI: 10.1021/acs.biochem.5b00762)
Darshan C. Patel, Zachary S. Breitbach, Ross M. Woods, Yeeun Lim, Andy Wang, Frank W. Foss Jr., and Daniel W. Armstrong “Gram Scale Conversion of R-BINAM to R-NOBIN” Journal of Organic Chemistry 2016, 81 (3), 1295–1299 (DOI: 10.1021/acs.joc.5b02663)
Mohammad S. Hossain, Cuong Q. Le, Ebenezer Joseph,a, Toan Q. Nguyen,a, Kayunta Johnson-Winters, Frank W. Foss Jr. “Convenient synthesis of FO and activity in F420-dependent NADP reductase” Organic and Biomolecular Chemistry, 2015, 13, 5082-5085 (DOI: 10.1039/C5OB00365B) Selected to a Themed Collection: 2015 Hot Articles in Organic and Biomolecular Chemistry
Bishnu P Subedi; Andra L Corder; Siai Zhang; Frank W Foss, Jr.; Brad S Pierce; “Steady-state kinetics and spectroscopic characterization of enzyme-tRNA interactions for the non-heme diiron tRNA-monooxygenase, MiaE” Biochemistry 2015 54(2):363-76. (DOI: 10.1021/bi5012207)
Jeremy S. Barnes; Frank W. Foss, Jr.; Kevin A Schug;"Thermally accelerated oxidative degradation of quercetin using continuous flow kinetic electrospray-ion trap-time of flight mass spectrometry" J Am Soc Mass Spectrom. 2013 24(10):1513-22. (DOI: 10.1007/s13361-013-0698-6)
Andra Carter, Bishnu Subedi, Amanda M. Dark, Frank W. Foss Jr.,* Brad S. Pierce* “Development of nucleoside substrate surrogates for the characterization of the O2-dependent tRNA modifying MiaE by peroxide-shunt catalysis.” Biochemistry 2013 52(36) 6182–6196.
Samuel H. Yang, Sumit Bhawal, Rajendrasing Deshmukh, Aruna B. Wijeratne, Brian L. Edwards, Frank W. Foss, Jr., Richard B. Timmons, Kevin A. Schug “Affinity Mesh Screen Materials for Rapid Drug Discovery Using Transmission Mode Desorption Electrospray Ionization Mass Spectrometry” Langmuir 2013 29(25) 8046–8053.
Shuai Chen, Frank W. Foss Jr.* “Aerobic Organocatalytic Oxidation of Aryl Aldehydes: Flavin Catalyst Turnover by Hantzsch’s Ester” Organic Letters, 2012, 14, 5150-5153. (DOI: 10.1021/ol302479b)
Jonathon M Bobbitt; Li Li; Doug D Carlton; Sumit Bhawal; Mahwish Yasin; Frank W Foss Jr.; Stefanie Wernisch; Reinhard Pell; Wolfgang Lindner; Kevin A. Schug, Ph.D. “Diastereoselective Discrimination of Lysine-alanine-alanine Peptides by Zwitterionic Cinchona Alkaloid-based Chiral Selectors using Electrospray Ionization Mass Spectrometry” Journal of Chromatography A, 2012; 1269, 308-315.
Shuai Chen, Mohammad S. Hossain, Frank W. Foss Jr.* “Organocatalytic Dakin Oxidation by Nucleophilic Flavin Catalysts” Organic Letters 2012, 14, 2806-2809 (DOI: 10.1021/ol3010326).
Xiaojia Huang, Frank W. Foss Jr., Purnendu K. Dasgupta “Multilayer chitosan-based open tubular capillary anion exchange column with integrated monolithic capillary suppressor” Analytica Chimica Acta 2011, 707, 210-217 (doi: 10.1016/j.aca.2011.09.028).
Severin Schneebeli, Maria Kamenetska, Frank Foss, Hector Vazquez, Rachid Skouta, Mark Hybertsen, Latha Venkataraman, Ronald Breslow “The Electrical Properties of Biphenylenes” Organic Letters 2010, 12, 4114-4117 (doi: 10.1021/ol1017036).
Janet V. Cross*, Joshua M. Rady, Frank W. Foss Jr., Charles Lyons, Timothy L. Macdonald, and Dennis J. Templeton “Nutrient Isothiocyanates Covalently Modify and Inhibit the Inflammatory Cytokine Macrophage Migration Inhibitory Factor (MIF)” Biochemical Journal 2009, 423, 315-321 (doi:10.1042/BJ20091170).
Frank W. Foss Jr., Thomas P. Mathews, Yugesh Kharel, Perry C. Kennedy, Ashley H. Snyder, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald “Synthesis and Biological Evaluation of Sphingosine Kinase Substrates as Sphingosine-1-Phosphate Receptor Prodrugs” Bioorganic & Medicinal Chemistry 2009, 17, 6123-6136 (doi:10.1016/j.bmc.2009.04.015).
Ronald Breslow, Frank W. Foss Jr.,Charge Transport in Nanoscale Aromatic and Antiaromatic Systems” Special Issue: Conductivity of single molecules and supramolecular architecturesJ. Phys.: Condens. Matter 2008, in press.
Huanyu Zhau, Frank W. Foss Jr, Ronald Breslow "Artificial Enzymes: Benzoin Condensations by Imidazolium and Thiazolium Catalysts" J. Am. Chem. Soc. 2008, in press.
Qin Sun, Ran Zhu, Frank W. Foss Jr., Timothy L. Macdonald “In Vitro Metabolism of a Model Cyclopropylamine to Reactive Intermediate: Insights into Trovafloxacin-Induced Hepatotoxicity” Chemical Research in Toxicology 2008, 21, 711-719; advance online publication, February 26th, 2008 (doi:10.1021/tx7003085).
Advertised by Chem. Res. Tox. as one of five non-CYP450 metabolism studies from 2008.
Guy Cinamon, Marcus A. Zachariah, Olivia M. Lam, Frank W. Foss Jr., Jason G. Cyster “Follicular Shuttling of Marginal Zone B Cells Facilitates Antigen Transport” Nature Immunology 2008, 9, 54-62. (Highlighted by Georg Kraal “Antigens Take the Shuttle” Nature Immunology 2008, 9, 11-12.)
Qin Sun, Ran Zhu, Frank W. Foss Jr., Timothy L. Macdonald “Synthesis and Chemical Oxidation of a Model Cyclopropylamine: Identification of a Reactive Intermediate and Implication of Responsible Enzymes for Hepatotoxicity of Trovafloxacin” Bioorg. Med. Chem. Let. 2007, 17, 6682-6686.
Jordan R. Quinn, Frank W. Foss Jr., Latha Venkataraman, Ronald Breslow “Oxidation Potentials Correlate with Conductivities of Aromatic Molecular Wires” J. Am. Chem. Soc. 2007, 129, 12376-12377.
Jordan R. Quinn, Frank W. Foss Jr., Latha Venkataraman, Mark S. Hybertsen, Ronald Breslow “Single-Molecule Junction Conductance through Diaminoacenes” J. Am. Chem. Soc. 2007, 129, 6714-6715.
Frank W. Foss Jr.,Ashley H. Snyder, Michael D. Davis, Michael Rouse, Mark D. Okusa, Kevin R. Lynch, Timothy L. Macdonald “Synthesis and Biological Evaluation of g-aminophosphonates as Potent, Subtype-Selective Sphingosine-1-Phosphate Receptor Agonists and Antagonists” Bioorg. Med. Chem. 2007, 15, 663-677;
(Top 50 cited BMC papers 2004-2008; and Recommended by Hugh Rosen: Faculty of 1000 Biology, 2 Feb 2007 http://www.f1000biology.com/article/id/1064759/evaluation.
Janet V. Cross, Frank W. Foss Jr., Joshua M. Rady, Timothy L. Macdonald, Dennis J. Templeton “The Isothiocyanate Class of Dietary Chemopreventives Inhibits the Catalytic Activity of the MEKK1 Protein Kinase by Covalent Modification of the ATP Binding Domain” BMC Cancer 2007, 7:183.
Alaa S. Awad, Hong Ye, Liping Huang, Frank W. Foss Jr., Li Li, Timothy L. Macdonald, Kevin R. Lynch, Mark D. Okusa “Selective Sphingosine 1-Phosphate (S1P1) Receptor Activation Reduces Ischemia-Reperfusion Injury in Mouse Kidney” Am. J. Physiol.: Renal Physiol. 2006, 290, F1516 - F1524.
Frank W. Foss Jr., Jeremy J. Clemens, Michael D. Davis, Ashley H. Snyder, Kevin R. Lynch, Timothy L. Macdonald “Synthesis, Stability and Implications of Phosphothioate Agonists of Sphingosine-1-Phosphate Receptors” Bioorg. Med. Chem. Lett. 2005, 15, 4470-4474.
2018 Regents’ Outstanding Teaching Awards for excellence in the classroom.
Presidents Award for Excellence in Teaching by an Untenured Faculty Member, UT Arlington, 2014
Student Organization Advisor of the Year, UTA Student Organizations, Nominated by the undergraduate Chemistry and Biochemistry Society, 2014
Phi Kappa Phi Recognized Professor, UTA Phi Kappa Phi Honor Society, 2013
Outstanding Mentor, Honorable Mention, ACES 2011-2012, Sigma Xi, UT Arlington Chapter, 2012
Phi Kappa Phi Recognized Professor, UTA Phi Kappa Phi Honor Society, 2009
Top 50 cited Publications 2004-2008, Bioorganic and Medicinal Chemistry, 2004-2008, 2009
Department of Chemistry Graduate Fellow, University of Virginia 2000-2003