Biological Nanosystems Engineering Laboratory

The Biological Nanosystems Engineering Lab applies biological systems to applications in chemistry, medicine, and materials research. Using a combination of biochemical and nanomaterials research, we will continue to produce exciting and revolutionary tools for innovative products and devices.

Research in the lab focuses on areas such as:

  • applied immunology
  • biochemical systems
  • bionanomaterials development


Justyn Jaworski, Ph.D., Lab Director

Current Research

  • 3D fabrication of microsystems with biological materials
  • Enzyme engineering
  • Chemical and biological sensing
  • Drug/probe discovery
  • Cellular reprogramming

Selected Publications


  • J. Jaworski, S.W. Lee, A. Majumdar, D.A. Raorane. “Receptors Useful for Gas Phase Chemical Sensing” (LBNL, USA) 2008 PCT/US2008/060260 US 8,957,013 B2 (Feb. 17, 2015).
  • J. Jaworski, H. Cho. “L-Abrine Detecting Sensor, Preparation Method Thereof and Method for Diagnosis of Abrin Poisoning Using the Same” (Hanyang University, South Korea) P20130579OP [10-2013-0127890] (25-Oct-2013)
  • J. Jaworski, J. Kim, E. Kwak, S. Oh, S. Jeon, S. Ahn, H. Chang. “3D Architectures from Biological Liquid Crystals for Sensing and Actuating Applications” (Hanyang University, South Korea) P20140154OP [10-2014-0048691] (23-April-2014)
  • J. Jaworski, H.S. Cheok. “Method for Highly Sensitive Immunosorbent Assay Based on Modified Phage Infectivity Readout” (Hanyang University, South Korea) P20150124OP [10-2015-0057978] (24-April-2015)
  • J. Jaworski, E. Kwak. “Construction of multicomponent structures using multi-barrel microcapillaries for 3D fabrication of composite materials and fibers” (Hanyang University, South Korea) P20160216OP [10-2016-0095357] (27-July-2016)

Books / Book Chapters

  • Jaworski, J. (2012) Biomimetic Molecular Recognition Elements for Chemical Sensing, in Biomimetic Approaches for Biomaterials Development (ed J. F. Mano), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527652273.ch6

Publications on Google Scholar

  • J. Jaworski and C. Klapperich. “Fibroblast remodeling activity at two- and three-dimensional collagen-glycosaminoglycan interfaces.” Biomaterials 27 (23), 4212-20 (2006)
  • S. Lim, J. Jaworski, S. Satyanarayana, F. Wang, D. Raorane, S.W. Lee, and A. Majumdar. “Nanomechanical Chemical Sensor Platform” Nano/Micro Engineered and Molecular Systems, Proceedings of the 2nd IEEE International Conference. 886-889, (2007)
  • J. Jaworski, D. Raorane, J. Huh, A. Majumdar, S.W. Lee. “Evolutionary Screening of Biomimetic Coatings for Selective Detection of Explosives.” Langmuir 24 (9), 4938-4943 (2008)
  • M. Cerruti, J. Jaworski, D. Raorane, C. Zueger, J. Varadarajan, C. Carraro, S.W. Lee, R. Maboudian, A. Majumdar. “Polymer-Oligopeptide Composite Coating for Selective Detection of Explosives in Water” Analytical Chemistry 81 (11), 4192–4199 (2009)
  • J. Jaworski, K. Yokoyama, C. Zeuger, W.J. Chung, S.W. Lee, A. Majumdar. “Polydiacetylene Incorporated with Peptide Receptors for the Detection of Trinitrotoluene Explosives” Langmuir 27 (6), 3180-3187 (2011)
  • T.H. Kim, B.Y. Lee, J. Jaworski, K. Yokoyama, W.J. Chung, E. Wang, S.H. Hong, A. Majumdar, S.W. Lee. “Selective and Sensitive TNT Sensors Using Biomimetic Polydiacetylene-Coated CNT-FETs” ACS Nano 5 (4), 2824-2830 (2011)
  • J.H. Lee, H.J. Lee, S.M. Seo, J. Jaworski, M.L. Seo, S.W. Kang, J.Y. Lee, J.H. Jung. “Fluorescence Enhancement of a Tetrazole-Based Pyridine Coordination Polymer Hydrogel” New Journal of Chemistry 35, 1054-1059 (2011)
  • J. Jaworski, D.H. Kim, K.M Jung, S.H. Kim, J.H. Jung, J.O. Jeong, H.S. Jeon, B.K. Min, K.Y. Kwon. “Surface Modification of Hydroxyapatite for Hydrogen Generation” Journal of Colloid and Interface Science 358 (2), 598-603 (2011)
  • Y.L. Choi, J. Jaworski, M.L. Seo, S.J. Lee, J.H. Jung. “Controlled Release Using Mesoporous Silica Nanoparticles Functionalized with 18-Crown-6 Derivatives” Journal of Materials Chemistry 21, 7882-7885 (2011)
  • Y.J Cho, J.H. Lee, J. Jaworski, S.H. Park, S.S. Lee, J.H. Jung. "The Influence of Ultrasound on Porphyrin-Based Metallogel Formation: Efficient Control of H-and J-Type Aggregations" New Journal of Chemistry 36, 32-25 (2012)
  • J.H. Lee, S.W. Kang, J. Jaworski, K.Y. Kwon, M.L. Seo, J.Y. Lee, J.H. Jung. "Fluorescent Composite Hydrogels of Metal–Organic Frameworks and Functionalized Graphene Oxide" Chemistry a European Journal 3, 765-769 (2012)
  • O. Yarimaga , J. Jaworski , B. Yoon, J.M. Kim. "Polydiacetylenes: Supramolecular Smart Materials with a Structural Hierarchy for Sensing, Imaging and Display Applications" Chemical Communications 48, 2469-2485 (2012)
  • Y.L. Choi, J.H. Lee, J. Jaworski, J.H. Jung. “Mesoporous Silica Nanoparticles Functionalized with Thymidine Derivative for Controlled Release” Journal of Materials Chemistry 22, 9455-9457 (2012)
  • J. Lee, B. Yoon, D.Y. Ham, O. Yarimaga, C. W. Lee, J. Jaworski, J.M. Kim. “Magnetically Responsive Inorganic/Polydiacetylene Nanohybrids” Macromolecular Chemistry and Physics, 213, 893-903 (2012)
  • H. Son, J.H. Lee, Y.R. Kim, I.S. Lee, S. Han, X. Liu, J. Jaworski, J.H. Jung. "A BODIPY-Functionalized Bimetallic Probe for Sensitive and Selective Color-Fluorometric Chemosensing of Hg2+" Analyst 137, 3914-3916 (2012)
  • D. Jin, J.H. Lee, M.L. Seo, J. Jaworski, J.H. Jung. "Controlled Drug Delivery from Mesoporous Silica Using a pH-Response Release System" New Journal of Chemistry 36, 1616-1620 (2012)
  • J.H. Jung, S.J. Moon, J. Ahn, J. Jaworski, S. Shinkai. "Controlled Supramolecular Assembly of Helical Silica Nanotube-Graphene Hybrids for Chiral Transcription and Separation" ACS Nano 7 (3), 2595–2601 (2013)
  • J. Jaworski, S. Cho, Y. Kim, J.H. Jung, H.S. Jeon, B.K. Min, K.Y. Kwon. "Hydroxyapatite Supported Cobalt Catalysts for Hydrogen Generation" Journal of Colloid and Interface Science, 394, 401–408 (2013)
  • D. Harjanto, J. Lee, J.M. Kim, J. Jaworski. "Controlling and Assessing the Surface Display of Cell-Binding Domains on Magnetite Conjugated Fluorescent Liposomes" Langmuir, 29 (25), 7949–7956 (2013)
  • E. Kwak, J. Jaworski. "Controlled Surface Immobilization of Virus via Site-Specific Enzymatic Modification" Journal of Materials Chemistry B, 1, 3486-3493 (2013)
  • J.H. Lee, J. Jaworski, J.H. Jung. "Luminescent Metal-Organic Framework-Functionalized Graphene Oxide Nanocomposites and Reversible Detection of High Explosives" Nanoscale 5, 8533-8540 (2013)
  • B. Yoon, J. Jaworski, J.M. Kim. "Size-Dependent Intercalation of Alkylamines within Polydiacetylene Supramolecules" Supramolecular Chemistry, 25 (1), 54-59 (2013)
  • J.H. Lee, S. Kang, J.Y. Lee, J. Jaworski, and J.H. Jung "Instant Visual Detection of Picogram Levels of Trinitrotoluene by Using Luminescent Metal–Organic Framework Gel‐Coated Filter Paper" Chemistry-A European Journal, 19 (49), 16665-16671 (2013)
  • J.H. Lee, J. Ahn, M. Masuda, J. Jaworski, J.H. Jung. "Reinforcement of a Sugar-Based Bolaamphiphile/Functionalized-Graphene Oxide Composite Gel; the Rheological and the Electrochemical Properties" Langmuir, 29 (44), 13535-13541 (2013)
  • S.J. Moon, S.H. Park, J. Jaworski, J.H. Jung. "Pyrene-Imidazolium Complexed Graphene for the Selective Fluorescent Detection of G-Quadruplex Forming DNA" Chemical Communications, 49, 11698-11700 (2013)
  • H. Cho, J. Jaworski. "A Portable and Chromogenic Enzyme-Based Sensor for Detection of Abrin Poisoning" Biosensors and Bioelectronics, 54, 667-673 (2014)
  • S. Nasir and J. Jaworski. "Assessing the Stability of Assembled Filamentous Phage Coat Protein P8" Supramolecular Chemistry, 26 (5-6), 329-337 (2014)
  • Y.S. Kang, H. Ahn, D. Song, J. Lee, E.M. Kang, J. Jaworski, J.M. Kim. "Promotion of Strongly Anchored Dyes on the Surface of Titania by Tetraethyl Orthosilicate Treatment for Enhanced Solar Cell Performance" Journal of Materials Chemistry A, 2 (7), 2250-2255 (2014)
  • S.H. Jung, J. Jeon, H. Kim, J. Jaworski, J.H. Jung. "Chiral Arrangement of Achiral Au Nanoparticles by Supramolecular Assembly of Helical Nanofiber Templates" Journal of the American Chemical Society, 136, 6446-6452 (2014)
  • S. Oh, E. Kwak, S. Jeon, S. Ahn, J.M. Kim, J. Jaworski. "Responsive 3D Microstructures from Virus Building Blocks" Advanced Materials, 26 (30), 5217–5222 (2014)
  • J. Park, J.H. Lee, J. Jaworski, S. Shinkai, J.H. Jung. "Luminescent Calix[4]arene-Based Metallogel Formed at Different Solvent Composition" Inorganic Chemistry, 53 (14), 7181–7187 (2014)
  • S. Ahn, S. Jeon, E. Kwak, J.M. Kim, J. Jaworski. "Virus-Based Surface Patterning of Biological Molecules, Probes, and Inorganic Materials" Colloids and Surfaces B: Biointerfaces, 122, 851-856 (2014)
  • H. Cho and J. Jaworski. "Enzyme Directed Formation of Un-natural Side-chains for Covalent Surface Attachment of Proteins" Colloids and Surfaces B: Biointerfaces, 122, 846–850 (2014)
  • A. Tentori and J. Jaworski. "Fabrication and Applications of Biological Fibers" Bio Design, 2 (3), 69-80 (2014)
  • S.H. Park, S. H. Jung, J. Ahn, J. Jeon, H. Kim, J. Jaworski, and J.H. Jung. "Reversibly tunable helix inversion in supramolecular gels triggered by Co2+" Chemical Communications, 50, 13495-13498 (2014)
  • J.Y. Kim, J. Jaworski "Amphiphilic Coatings on Cobalt Boride Nanocatalysts for Stability in Hydrogen Generation Applications" Macromolecular Research, 23, (2015)
  • J.H. Lee, J. Park, J.W. Park, H.J. Ahn, J. Jaworski, J.H. Jung. "Supramolecular Gels with High Strength by Tuning of Calix[4]arene-Derived Networks" Nature Communications, 6, 6650 (2015) doi:10.1038/ncomms7650
  • E. Kwak, S. Ahn, J. Jaworski. "Microfabrication of Custom Collagen Structures Capable of Guiding Cell Morphology and Alignment" Biomacromolecules, 16 (6), 1761–1770 (2015)
  • S.H. Jung, J. Jeon, H. Kim, J. Jaworski, J.H. Jung. "Chirality Control of Self-assembled Achiral Nanofibers using Amines in their Solid State" Nanoscale, 7 (37), 15238-15244 (2015)
  • H. Cheok and J. Jaworski. "Virus-based Assay for Antigen Detection using Infective Growth as Signal Transduction Mechanism" Biosensors and Bioelectronics, 77, 131-136 (2016)
  • H. Cheok and J. Jaworski. "Phage Based Screening Strategy for Identifying Enzyme Substrates" Biochemical Engineering Journal, (2016) doi: 10.1016/j.bej.2015.10.022
  • P. Foo, H. Cheok, T. Cavalcanti, G. Lim, E. Kwak, J. Jaworski. "Development and Characterization of Polyethylenimine Nanocarriers Processed by an Inductive Thermospraying Technique" Macromolecular Research, 24 (2016)
  • S.H. Jung, K.Y. Kim, A. Ahn, M.Y. Choi, J. Jaworski, J.H. Jung. "Determining Chiral Configuration of Diamines via Contact Angle Measurements on Enantioselective Alanine-Appended Benzene-Tricarboxamide Gelators" ACS Applied Materials & Interfaces (2016)
  • S.H. Jung, K.Y. Kim, A. Ahn, S.S. Lee, M.Y. Choi, J. Jaworski, J.H. Jung "NMR Detection of Chirality and Enantiopurity for Amines by Using Benzene Tricarboxamide-Based Hydrogelators as Chiral Solvating Agents" New Journal of Chemistry (2016)
  • M. Seo, D. Park, C.W. Lee, J. Jaworski, J.M. Kim, "Fluorometric Measurement of Individual Stomata Activity and Transpiration via a Brush-on, Water-Responsive Polymer" Scientific Reports, 6, 32394 (2016) doi:10.1038/srep32394)
  • J. Jaworski, E. Z. Nezhad et al "From Zirconium Nanograins to Zirconia Nanoneedles" Scientific Reports 2016
  • S.H. Jung, K.Y. Kim, J.H. Lee, C.J. Moon, N.S. Han, S.J. Park, D. Kang, J.K. Song, S.S. Lee, M.Y. Choi, J. Jaworski, J.H. Jung. "Self-Assembled Tb3+ Complex Probe for Quantitative Analysis of ATP during Its Enzymatic Hydrolysis via Time-Resolved Luminescence in Vitro and In Vivo" ACS Applied Materials & Interfaces (2016)
  • J.H. Je, J.M. Kim, J. Jaworski "Progression in the Fountain Pen Approach: From 2D Writing to 3D Free-form Micro/Nanofabrication" Small, 13 (2), 1600137–1600158 (2017)
  • J.H. Lee, S.H. Jung, S.S. Lee, K.Y. Kwon, K. Sakurai, J. Jaworski, J.H. Jung. "Ultraviolet Patterned Calixarene-Derived Supramolecular Gels and Films with Spatially Resolved Mechanical and Fluorescent Properties" ACS NANO, 11(4), 4155-4164 (2017)
  • E. Kwak, D. Dutra, M. Becker, K. Uh, J. Jaworski. "Cobalt and Magnetite Functionalized Virus Nanofibers for Hydrogen Generation" J. Nanosci. Nanotech, 17, 2116-2123 (2017)
  • S. Sandhu, L. Kydd, J. Jaworski "Luminescent Probe Based Techniques for Hypoxia Imaging" Journal of Nanomedicine Research (2017)
  • I. Song, H. Park, J.H. Park, H. Kim, S.H. Kim, S. Yi, J. Jaworski, B.I. Sang "Silica formation with nanofiber morphology via helical display of the silaffin R5 peptide on a filamentous bacteriophage" Scientific Reports, 7,16212 (2017)